共查询到20条相似文献,搜索用时 62 毫秒
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Simonsson M Heldin CH Ericsson J Grönroos E 《The Journal of biological chemistry》2005,280(23):21797-21803
Transforming growth factor beta (TGFbeta) regulates multiple cellular processes via activation of Smad signaling pathways. We have recently demonstrated that the inhibitory Smad7 interacts with the acetyl transferase p300 and that p300 acetylates Smad7 on two lysine residues. These lysine residues are critical for Smurf-mediated ubiquitination of Smad7, and acetylation protects Smad7 from TGFbeta-induced degradation. In this study we demonstrate that Smad7 interacts with specific histone deacetylases (HDACs) and that the same HDACs are able to deacetylate Smad7. The interaction with HDACs is dependent on the C-terminal MH2 domain of Smad7. In addition, HDAC1-mediated deacetylation of Smad7 decreases the stability of Smad7 by enhancing its ubiquitination. Thus, our results demonstrate that the degradation of Smad7 is regulated by the balance between acetylation, deacetylation and ubiquitination, indicating that this could be a general mechanism to regulate the stability of cellular proteins. 相似文献
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Qiu P Ritchie RP Gong XQ Hamamori Y Li L 《Biochemical and biophysical research communications》2006,348(2):351-358
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Pan D Estévez-Salmerón LD Stroschein SL Zhu X He J Zhou S Luo K 《The Journal of biological chemistry》2005,280(16):15992-16001
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In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions 总被引:5,自引:0,他引:5
Miao F Gonzalo IG Lanting L Natarajan R 《The Journal of biological chemistry》2004,279(17):18091-18097
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E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins. 总被引:2,自引:0,他引:2
A Nishihara J Hanai T Imamura K Miyazono M Kawabata 《The Journal of biological chemistry》1999,274(40):28716-28723
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Coss D Hand CM Yaphockun KK Ely HA Mellon PL 《Molecular endocrinology (Baltimore, Md.)》2007,21(12):3071-3086