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Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. 总被引:7,自引:0,他引:7
Pulak R Manna Matthew T Dyson Darrell W Eubank Barbara J Clark Enzo Lalli Paolo Sassone-Corsi Anthony J Zeleznik Douglas M Stocco 《Molecular endocrinology (Baltimore, Md.)》2002,16(1):184-199
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Lopez D Niesen M Bedi M Hale D McLean MP 《Biochemical and biophysical research communications》2007,357(2):549-553
Sterol carrier protein X (SCPx) is a peroxisomal protein with both lipid transfer and thiolase activity. Treatment of mouse adrenal Y1 cells with cAMP for 24h caused a significant induction of SCPx mRNA levels. Reporter gene studies demonstrated that treatment with cAMP and SF-1 was able to activate the SCPx promoter. Sequence analysis revealed the presence of three putative steroidogenic factor-1 (SF-1) binding motifs (designated SFB1, SFB2, and SFB3) and one CRE. Only SFB1 and SFB3 were able to bind recombinant SF-1 protein in electrophoretic mobility shift assays. The CRE was able to form a DNA/protein complex in the presence of Y1 nuclear extracts. Mutational analysis studies demonstrated that SFB3 is required for full activation of the SCPx promoter by cAMP treatment. Regulation of the SCPx gene by SF-1 and cAMP is similar to the regulatory mechanisms observed for other steroidogenic genes. 相似文献
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J A Bokar W J Roesler G R Vandenbark D M Kaetzel R W Hanson J H Nilson 《The Journal of biological chemistry》1988,263(36):19740-19747