Deep Characterization of the Human Antibody Response to Natural Infection Using Longitudinal Immune Repertoire Sequencing

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Highlights

• •Longitudinal monitoring of B cell subsets shows baseline antibody gene expression.
• •A single, given CDR3 sequence can arise from more than one VJ gene combination.
• •A healthy individual's V gene usage is stable irrespective of infection and subset.
• •Surprisingly, class-switched antibodies can occur early in human B cell development.

     

Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer

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Highlights

• •HuProt array-based identification of autoantigens in serum of early lung cancer.
• •Independent validation of early lung cancer biomarker candidates with ELISA.
• •Bioinformatics-aided identification of a biomarker panel.
• •Independent verification of the panel with ELISA and immunohistochemistry.

     

Parinarioidins A-B,unprecedented flavonoids from the bark of Brosimum parinarioides Ducke

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The Circadian Clock Gene Circuit Controls Protein and Phosphoprotein Rhythms in Arabidopsis thaliana

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The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis

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Highlights

• •Mitochondrial heart N terminome shows aminopeptidase processing after MTS cleavage.
• •CLPP-deficiency alters protein processing patterns in mouse heart mitochondria.
• •Candidate substrates identified by N termini accumulation and interaction with inactive ClpXP.
• •UQCRC1, HSPA9 and OAT validated biochemically as high confidence ClpXP substrates.

     

BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development

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Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles

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Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain

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Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

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Orientation Preference Maps in Microcebus murinus Reveal Size-Invariant Design Principles in Primate Visual Cortex

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A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis

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Engineering genetic circuits: advancements in genetic design automation tools and standards for synthetic biology

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The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

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Layer 6b Is Driven by Intracortical Long-Range Projection Neurons

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Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential

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Probing RNA Conformational Equilibria within the Functional Cellular Context

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CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles

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