•Using ExCYT, genomics, and Mass Spectrometry, we were able to uncover immune cell marker alterations that provide new insight into the biology of early stage ccRCC.
•Among the CD45+ population, we observed a high level of myeloid cell infiltration in treatment-naïve ccRCC tissues.
Microparticles as tissue modulators provide a higher control of cell fate during the process of tissue regeneration. Through their design, they deliver instructive cues to cells in a more efficient way improving the success of bottom-up approaches.
•Develop a TMT-based proteomics tool to profile cysteine persulfides in the cellular proteomes.
•Discover a Redox Thiol Switch from protein S-glutathioinylation to S-persulfidation (RTSGS) with implications in the regulation of cellular energy metabolism under oxidative stress.
Schematic showing the main categories of models incorporating structured biological data covered in this review. The first panel shows an example of a model operating on sequence data, the second panel shows a model in which dimension reduction is influenced by the connections in a gene network, and the third panel shows a neural network with structure constrained by a phylogeny or ontology. The ‘x’ values in the data tables represent gene expression measurements. 相似文献
Overview of recent advancements to make synthetic biology ready for deployment. (Top left) Biocontainment of engineered microbes once they exit the target environment. (Top right) Genetic stability of synthetic circuitry against mutation and loss of function. (Bottom left) Resource feedback to mitigate effects of circuit burden and host-state coupling. (Bottom right) Variability control within engineered populations to optimize output and reduce susceptibility to perturbation.相似文献
