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Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene. 总被引:66,自引:41,他引:25
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E A Sternberg G Spizz W M Perry D Vizard T Weil E N Olson 《Molecular and cellular biology》1988,8(7):2896-2909
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Biederer CH Ries SJ Moser M Florio M Israel MA McCormick F Buettner R 《The Journal of biological chemistry》2000,275(34):26245-26251
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AF Brooks CS Vélez-Martínez HD Hollis Showalter GA Garcia 《Biochemical and biophysical research communications》2012,419(1):83-88
Canonical Wnt signaling plays important roles in regulating cell proliferation and differentiation. In this study, we report that inhibitor of differentiation (Id)3 is a Wnt-inducible gene in mouse C2C12 myoblasts. Wnt3a induced Id3 expression in a β-catenin-dependent manner. Bone morphogenetic protein (BMP) also potently induced Id3 expression. However, Wnt-induced Id3 expression occurred independent of the BMP/Smad pathway. Functional studies showed that Id3 depletion in C2C12 cells impaired Wnt3a-induced cell proliferation and alkaline phosphatase activity, an early marker of osteoblast cells. Id3 depletion elevated myogenin induction during myogenic differentiation and partially impaired Wnt3a suppressed myogenin expression in C2C12 cells. These results suggest that Id3 is an important Wnt/β-catenin induced gene in myoblast cell fate determination. 相似文献
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Functional analysis of the Myostatin gene promoter in sheep 总被引:3,自引:0,他引:3
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