DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

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Structural basis for Cas9 off-target activity

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Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease

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Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity

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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

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Cas9 deactivation with photocleavable guide RNAs

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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

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Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage

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Recording of elapsed time and temporal information about biological events using Cas9

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High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation

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DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat

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Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities

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Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development

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ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

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EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

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Structure and functionality of a multimeric human COQ7:COQ9 complex

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Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development

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Structure and regulation of the microtubule plus-end tracking protein Kar9

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Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins

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