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Heck MM 《BioEssays : news and reviews in molecular, cellular and developmental biology》1999,21(12):985-990
The intrinsic polarity of microtubules within cells is exploited each time cells divide. Kinesins, microtubule-associated motor proteins, are required to execute the dramatic events of mitosis: bipolar spindle assembly, metaphase chromosome alignment, anaphase chromosome segregation, and separation of spindle poles prior to cytokinesis. Surprisingly, kinesin-related proteins have been found to move in either "plus-ward" or "minus-ward" directions along microtubules. Evidence from genetic analyses of simple eukaryotes and in vitro activity assays supports the notion that certain subfamilies of kinesin-related proteins provide antagonistic activities necessary to balance mitotic forces. A recent study by Sharp et al.((1)) sheds further light on the subject by exploiting the genetics and cytology of the fruit fly embryo. 相似文献
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Mary M. Rayner 《BMJ (Clinical research ed.)》1958,2(5111):1537-1538
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R. Hewitt 《BMJ (Clinical research ed.)》1958,2(5110):1473-1474
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Russell Brain 《BMJ (Clinical research ed.)》1953,2(4849):1283-1284
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J. A. Frais 《BMJ (Clinical research ed.)》1958,2(5109):1412-1412
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