共查询到20条相似文献,搜索用时 15 毫秒
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Ribeiro DL Caldeira EJ Cândido EM Manzato AJ Taboga SR Cagnon VH 《European journal of histochemistry : EJH》2006,50(1):51-60
The diabetes causes alterations in various organ systems, including the male accessory sex glands. The prostate is very important in the reproductive process and it is a frequent target of malignant changes. The aim of this work was to demonstrate the histochemical and ultrastructural alterations in the prostate of diabetic animals. Two groups of animals were utilized: control and non-obese diabetic mice (NOD). Twelve days after the characterization of diabetic status the ventral prostate was collected, fixed in Karnovsky and paraformaldehyde, processed for histochemistry and TEM associated to stereology. The results showed reduction of the epithelial area and increasing of the stromal area with muscular and collagen hypertrophy in the prostatic gland. It was characterized the development of prostatic intraepithelial neoplasia, inflammatory processes and dilation of the organelles involved in the secretory process. It was concluded that diabetes besides damaging the reproductive process, affects the glandular homeostasis favoring the development of prostatic pathologies. 相似文献
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Albena Alexandrova Lubomir Petrov Margarita Kirkova 《Central European Journal of Biology》2006,1(2):289-298
Numerous studies have indicated that oxidative stress contributes to the development and progression of diabetes and other
related complications. Since the ubiquitin-proteasome pathway is involved in degradation of oxidized proteins, it is to be
expected that alterations in proteasome-dependent proteolysis accompany diabetes. This paper focuses on the role of the proteasome
in alloxan-induced experimental diabetes. The changes in proteasomal activity and oxidative stress indices (protein oxidation
and lipid peroxidation) were evaluated. The obtained results revealed increased protein oxidation and lipid peroxidation,
as well as alterations in proteasomal activities in diabetic rats. Our data indicates a significant decrease in chymotryptic-like
activity; increased tryptic-like activity; and unchanged post-glutamyl peptide hydrolytic-like activity. These findings suggest
the presence of oxidative stress in diabetes that appears to result in changes to the ubiquitin-proteasome pathway. 相似文献
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P. G. H. Gell 《BMJ (Clinical research ed.)》1945,2(4426):622-623
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