共查询到20条相似文献,搜索用时 15 毫秒
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F. J. Wright 《BMJ (Clinical research ed.)》1995,310(6974):261-262
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E D Samokhodkina I V Ryzhko A I Shcherbaniuk I V Kasatkina R I Tsuraeva T A Zhigalova 《Antibiotiki i khimioterapii͡a》1992,37(11):26-28
A comparative study was performed on the efficacy of doxycycline in experimental plague infection induced in albino mice by strain 231 of the plague microbe and its variant 231 Fra- deprived of the ability to produce the fraction I antigen. It was shown that the LD50 for strain 231 during animal treatment with doxycycline was significantly higher than that for variant 231 Fra-. Prophylaxis of the plague infection caused by the Fra- forms of the plague microbe required significantly higher doses of doxycycline (ED50) than that of the infection caused by the Fra+ forms. The use of the daily maximum permissible doses of doxycycline (50 to 100 mg/kg a day) for 10 days in treatment of albino mice infected with the strain Fra- did not provide animal survival at the level higher than 60 to 70 per cent while the survival rate in the animals infected with the strain Fra+ of the plague microbe and treated according to the same scheme amounted to 90-100 per cent. The lower therapeutic efficacy of doxycycline in the treatment of the infection caused by the fractionless variant of the plague microbe should be considered in development of rational schemes for prophylaxis and treatment of plague. 相似文献
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Carniel E 《Comptes rendus biologies》2002,325(8):851-3; discussion 879-83
The plague has been one of the most devastating diseases of human history. Despite major advances in diagnosis, prevention, and treatment, it has not been possible to eradicate this infection. Plague is still active in Africa, in Asia and in the Americas, and is classified as a currently re-emerging disease. The plague is mainly a disease of rodents, which is transmitted by fleabites. Humans develop two main clinical forms: bubonic plague (following bites of infected fleas, lethal in 50-70% of the cases in less than a week if an appropriate treatment is not started rapidly), and pneumonic plague (after inhalation of infected droplets, lethal in less than three days in 100% of cases without immediate treatment). Y. pestis, the causative agent of plague, is usually sensitive to most antibiotics, but the first multi-resistant strain was recently described. No efficient and safe vaccines are currently available. The plague bacillus is one of the few organisms that could be used for biological warfare. 相似文献
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A K Akiev I D Ladny 《Journal of hygiene, epidemiology, microbiology, and immunology》1976,20(4):410-418
General principles and organizational forms of epidemiological surveillance of plague in the USSR both in seaports andin natural foci are discussed. On the basis of the analysis of the authors' experience over many years and taking into consideration literary data, the authors recommend a minimum, but in their opinion effective amount of a successful realization of these recommendations, it is expedient to establish a special team (or teams) consisting of 10-12 members. 相似文献
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