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Structure and function of y chromosomal DNA 总被引:2,自引:0,他引:2
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Autosomal genes involved in mammalian primary sex determination 总被引:1,自引:0,他引:1
E M Eicher 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》1988,322(1208):109-118
Beginning with findings made during the late 1950s and early 1960s, evidence continues to accumulate in support of the hypothesis that the mammalian Y chromosome carries a gene that induces the undifferentiated foetal gonad in XY individuals to develop as a testis. Recently a DNA sequence has been isolated from the human Y chromosome that appears to be the hypothesized Y-linked testis-determining gene, and advances have also been made toward identifying genes that interact with the Y-linked testis-determining (Tdy) gene to initiate testis formation. These loci have been identified in specific stocks of mice carrying the mutant Thp or TOrl allele at the T locus located on chromosome 17, and in crosses involving the transfer of a Y chromosome from two populations of Mus domesticus into the genomes of specific inbred strains of mice. The data in both cases support the hypothesis that there are several loci involved in testis determination and that abnormal interaction of these loci disrupts initiation of testis determination, resulting in development of ovarian tissue in XY individuals. 相似文献
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Detailed Structure of the Drosophila Melanogaster Stellate Genes and Their Transcripts 总被引:2,自引:0,他引:2
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K. J. Livak 《Genetics》1990,124(2):303-316
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Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9 总被引:10,自引:3,他引:7
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N A Affara D Chambers J O''''Brien S S Habeebu M Kalaitsidaki C E Bishop M A Ferguson-Smith 《Nucleic acids research》1989,17(8):2987-2999