The use of radioactive iodine in the treatment of Graves disease

Fifty patients with uncomplicated Graves' disease were treated with radioactive iodine (I(131)). Twenty-six patients who were followed for one year or longer are the basis of this report. Twenty-five are now euthyroid; only one is not completely well. The total dose of radioiodine administered varied from 0.5 to 10 millicuries. The average length of time necessary for return to a euthyroid state was from three to four months. Hypometabolism developed in three patients, and in one the signs and symptoms of myxedema developed. No other complications ensued. One patient who apparently relapsed had complete return to normal after further iodine administration. The determination of the uptake of radioactive iodine by the thyroid gland is a useful diagnostic procedure in differentiating conditions simulating hyperthyroidism.Following treatment with radioactive iodine, the thyroid gland becomes smaller, the uptake of iodine by the gland is reduced, and the level of organic iodine in the plasma becomes normal. In acute thyroiditis, in spite of a high basal metabolic rate, high content of organic iodine in the plasma and other evidences of "hyperthyroidism," the uptake of I(131) has been very low.     

Therapeutic studies in hyperthyroidism; use of radioactive iodine

Of 112 patients with hyperthyroidism who were treated with radioactive iodine, 110 were relieved of the disease. Nine had transient hypothyroidism. Twelve had permanent hypothyroidism. No other adverse effects that could be attributed to radioactive iodine were noted.     

几种蔬菜对外源碘的吸收与积累特性

在盆栽条件下研究了小白菜、芹菜、辣椒和萝卜4种蔬菜对2种外源碘(海藻固体碘肥和KI)的吸收与积累特性.结果表明:蔬菜体内的碘含量均随外源碘浓度的提高而逐渐增加;不同蔬菜种类对碘的吸收与积累能力存在较大差异,叶菜类的小白菜对碘的积累能力最强,其次为茎菜类的芹菜,而根菜类的萝卜和果菜类的辣椒吸收与积累碘的能力较弱;碘在蔬菜体内的分布一般为根>叶>茎>果实,但萝卜地下块根的碘含量低于地上部分.低浓度碘处理(0～25mg.kg-1)对蔬菜生长没有明显的影响,但高浓度的外源碘(≥50mg.kg-1)对蔬菜生长有抑制作用,导致蔬菜生物量减少.不同蔬菜对碘的敏感反应表现为辣椒>小白菜>芹菜>萝卜.与海藻固体碘肥相比,KI处理的第1茬蔬菜生物量下降明显(P<0.05),而2种外源碘对第2茬蔬菜的生长均无显著影响.蔬菜对2种外源碘的吸收和积累效果同样存在很大差异(P<0.05),第1茬蔬菜对KI的吸收能力强于海藻碘肥(P<0.05),第2茬蔬菜对KI的吸收量迅速下降,而对海藻固体碘肥的吸收下降不明显,说明海藻固体碘肥比KI具有更长的持效性.