共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
Steffi Heidenreich Pamela Weber Heike Stephanowitz Konstantin M. Petricek Till Schütte Moritz Oster Antti M. Salo Miriam Knauer Isabel Goehring Na Yang Nicole Witte Anne Schumann Manuela Sommerfeld Matthias Muenzner Johanna Myllyharju Eberhard Krause Michael Schupp 《The Journal of biological chemistry》2020,295(50):17158
10.
11.
Masashi Fukasawa R. Max Wynn Kosaku Uyeda 《Biochemical and biophysical research communications》2010,391(2):1166-28127
12.
13.
14.
15.
16.
17.
18.
19.
Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (−2000 to +65 bp) revealed a glucose responsive region between −74 and −52 bp. These findings suggest that FGF21 expression is regulated by ChREBP. 相似文献