共查询到20条相似文献,搜索用时 31 毫秒
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Gene batteries are sets of coregulated genes with common cis-regulatory elements that define the differentiated state of a cell. The nature of gene batteries for individual neuronal cellular subtypes and their linked cis-regulatory elements is poorly defined. Through molecular dissection of the highly modular cis-regulatory architecture of individual neuronally expressed genes, we have defined a conserved 16 bp cis-regulatory motif that drives gene expression in a single interneuron subtype, termed AIY, in the nematode Caenorhabditis elegans. This motif is bound and activated by the Paired- and LIM-type homeodomain proteins CEH-10 and TTX-3. Using genome-wide phylogenetic footprinting, we delineated the location, distribution, and evolution of AIY-specific cis-regulatory elements throughout the genome and thereby defined a large battery of AIY-expressed genes, all of which represent direct Paired/LIM homeodomain target genes. The identity of these homeodomain targets provides novel insights into the biology of the AIY interneuron. 相似文献
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Retinoic acid-induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif. 总被引:9,自引:3,他引:6 下载免费PDF全文
M P Felli A Vacca D Meco I Screpanti A R Farina M Maroder S Martinotti E Petrangeli L Frati A Gulino 《Molecular and cellular biology》1991,11(9):4771-4778
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Transcriptional enhancers can act in trans 总被引:11,自引:0,他引:11
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