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Kozuka T Sugita M Shetzline S Gewirtz AM Nakata Y 《Journal of immunology (Baltimore, Md. : 1950)》2011,187(11):5974-5982
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Reciprocal changes in the expression of transcription factors GATA-4 and GATA-6 accompany adrenocortical tumorigenesis in mice and humans. 总被引:4,自引:0,他引:4
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S. Kiiveri S. Siltanen N. Rahman M. Bielinska V. P. Lehto I. T. Huhtaniemi L. J. Muglia D. B. Wilson M. Heikinheimo 《Molecular medicine (Cambridge, Mass.)》1999,5(7):490-501
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Martin LJ Taniguchi H Robert NM Simard J Tremblay JJ Viger RS 《Molecular endocrinology (Baltimore, Md.)》2005,19(9):2358-2370
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Maneechotesuwan K Xin Y Ito K Jazrawi E Lee KY Usmani OS Barnes PJ Adcock IM 《Journal of immunology (Baltimore, Md. : 1950)》2007,178(4):2491-2498
GATA-3 plays a critical role in allergic diseases by regulating the release of cytokines from Th2 lymphocytes. However, the molecular mechanisms involved in the regulation of GATA-3 in human T lymphocytes are not yet understood. Using small interfering RNA to knock down GATA-3, we have demonstrated its critical role in regulating IL-4, IL-5, and IL-13 release from a human T cell line. Specific stimulation of T lymphocytes by costimulation of CD3 and CD28 to mimic activation by APCs induces translocation of GATA-3 from the cytoplasm to the nucleus, with binding to the promoter region of Th2 cytokine genes, as determined by chromatin immunoprecipitation. GATA-3 nuclear translocation is dependent on its phosphorylation on serine residues by p38 MAPK, which facilitates interaction with the nuclear transporter protein importin-alpha. This provides a means whereby allergen exposure leads to the expression of Th2 cytokines, and this novel mechanism may provide new approaches to treating allergic diseases. 相似文献
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Kittipong Maneechotesuwan Xin Yao Kazuhiro Ito Elen Jazrawi Omar S. Usmani Ian M. Adcock Peter J. Barnes 《PLoS medicine》2009,6(5)