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F Borellini Y F He A Aquino G Yu S F Josephs R I Glazer 《The Journal of biological chemistry》1991,266(24):15850-15854
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Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein. 总被引:21,自引:5,他引:16
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An erythroid specific, inducible enhancer associated with hypersensitive site II (HS II) plays a central role in the function of the human beta globin dominant control region. The HS II enhancer consists of tandem AP-1 binding sites and has been shown to bind members of the ubiquitous jun and fos families of proteins. The same sites are now shown to bind the erythroid specific protein, NF-E2. Inducibility of the HS II enhancer depends on NF-E2 binding, even in the presence of another hypersensitive site. Further, increased activity of the enhancer in induced K562 cells correlates with the presence of NF-E2, which appears to be present in a modified form. NF-E2 is distinct from some enhancer binding proteins in K562 nuclear extracts, in that it does not contain Fos or Fra-1 protein. Thus, binding by NF-E2 may be the mechanism, whereby tandem AP-1 binding sites confer erythroid specificity on the HS II enhancer. 相似文献
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Sp1 transactivation of the TCL1 oncogene 总被引:3,自引:0,他引:3
French SW Malone CS Shen RR Renard M Henson SE Miner MD Wall R Teitell MA 《The Journal of biological chemistry》2003,278(2):948-955