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Expression of murine IL-12 is regulated by translational control of the p35 subunit 总被引:12,自引:0,他引:12
Babik JM Adams E Tone Y Fairchild PJ Tone M Waldmann H 《Journal of immunology (Baltimore, Md. : 1950)》1999,162(7):4069-4078
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Zou W Amcheslavsky A Takeshita S Drissi H Bar-Shavit Z 《Journal of cellular physiology》2005,202(2):371-378
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Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex. 总被引:7,自引:5,他引:2
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M C Birchenall-Roberts F W Ruscetti J Kasper H D Lee R Friedman A Geiser M B Sporn A B Roberts S J Kim 《Molecular and cellular biology》1990,10(9):4978-4983
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The vacuolar (H(+))-ATPase (V-ATPase) is crucial for multiple processes within the eukaryotic cell, including membrane transport and neurotransmitter secretion. How the V-ATPase is regulated, e.g. by an accessory subunit, remains elusive. Here we explored the role of the neuroendocrine V-ATPase accessory subunit Ac45 via its transgenic expression specifically in the Xenopus intermediate pituitary melanotrope cell model. The Ac45-transgene product did not affect the levels of the prohormone proopiomelanocortin nor of V-ATPase subunits, but rather caused an accumulation of the V-ATPase at the plasma membrane. Furthermore, a higher abundance of secretory granules, protrusions of the plasma membrane and an increased Ca(2+)-dependent secretion efficiency were observed in the Ac45-transgenic cells. We conclude that in neuroendocrine cells Ac45 guides the V-ATPase through the secretory pathway, thereby regulating the V-ATPase-mediated process of Ca(2+)-dependent peptide secretion. 相似文献
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