共查询到20条相似文献,搜索用时 31 毫秒
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EWS, but Not EWS-FLI-1, Is Associated with Both TFIID and RNA Polymerase II: Interactions between Two Members of the TET Family, EWS and hTAFII68, and Subunits of TFIID and RNA Polymerase II Complexes 总被引:6,自引:2,他引:4
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Anne Bertolotti Thomas Melot Joël Acker Marc Vigneron Olivier Delattre Laszlo Tora 《Molecular and cellular biology》1998,18(3):1489-1497
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A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein. 总被引:16,自引:2,他引:14
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C Jousset C Carron A Boureux C T Quang C Oury I Dusanter-Fourt M Charon J Levin O Bernard J Ghysdael 《The EMBO journal》1997,16(1):69-82
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Identification of c-myc as a down-stream target for pituitary tumor-transforming gene 总被引:43,自引:0,他引:43
Pei L 《The Journal of biological chemistry》2001,276(11):8484-8491
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Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription 总被引:1,自引:0,他引:1
Araya N Hirota K Shimamoto Y Miyagishi M Yoshida E Ishida J Kaneko S Kaneko M Nakajima T Fukamizu A 《The Journal of biological chemistry》2003,278(7):5427-5432
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The t(6;22)(p21;q12) translocation associated with human bone and soft-tissue tumours results in a chimaeric molecule fusing the NTD (N-terminal domain) of the EWS (Ewing's sarcoma) gene to the CTD (C-terminal domain) of the Oct-4 (octamer-4) embryonic gene. Since the N-terminal domains of EWS and Oct-4 are structurally different, in the present study we have assessed the functional consequences of the EWS-Oct-4 fusion. We find that this chimaeric gene encodes a nuclear protein which binds DNA with the same sequence specificity as the parental Oct-4 protein. Comparison of the transactivation properties of EWS-Oct-4 and Oct-4 indicates that the former has higher transactivation activity for a known target reporter gene containing Oct-4 binding. Deletion analysis of the functional domains of EWS-Oct-4 indicates that the EWS (NTD), the POU domain and the CTD of EWS-Oct-4 are necessary for full transactivation potential. EWS-Oct-4 induced the expression of fgf-4 (fibroblast growth factor 4) and nanog, which are potent mitogens as well as Oct-4 downstream target genes whose promoters contain potential Oct-4-binding sites. Finally, ectopic expression of EWS-Oct-4 in Oct-4-null ZHBTc4 ES (embryonic stem) cells resulted in increased tumorigenic growth potential in nude mice. These results suggest that the oncogenic effect of the t(6;22) translocation is due to the EWS-Oct-4 chimaeric protein and that fusion of the EWS NTD to the Oct-4 DNA-binding domain produces a transforming chimaeric product. 相似文献
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An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.
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T Tanaka K Tanaka S Ogawa M Kurokawa K Mitani J Nishida Y Shibata Y Yazaki H Hirai 《The EMBO journal》1995,14(2):341-350