共查询到20条相似文献,搜索用时 15 毫秒
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Jean-Jacques Hublin Darlene Weston Philipp Gunz Mike Richards Wil Roebroeks Jan Glimmerveen Luc Anthonis 《Journal of human evolution》2009,57(6):777-785
In 2001, a portion of human frontal bone was discovered in sediments extracted from the bottom of the North Sea, 15 km off the coast of the Netherlands. The extraction zone is located in the so-called Zeeland Ridges area located at 51°40′ northern latitude and 3°20′ eastern longitude. The specimen was dredged up from sediments containing Late Pleistocene faunal remains and Middle Palaeolithic artefacts, including well-finished small handaxes and Levallois flakes. The details of the supraorbital morphology, as well as the quantitative assessment of the shape of the external surface of the squama using traditional and 3D geometric morphometrics, unambiguously assign the Zeeland Ridges frontal bone to Homo neanderthalensis. Carbon and nitrogen isotopic analysis indicate that the Zeeland Ridges hominin, like other Neandertals, was highly carnivorous and does not show evidence for the consumption of aquatic foods. A lesion on the outer table and diploic layer of the bone in the area of the supratoral sulcus can be interpreted as the result of an intradiploic epidermoid cyst, a type of neoplasm diagnosed for the first time in Neandertal remains. So far, the Zeeland Ridges Neandertal is the first Pleistocene fossil hominin found under seawater and the first recorded in the Netherlands. 相似文献
3.
Bielicki T Szklarska A Welon Z Rogucka E 《American journal of physical anthropology》2001,114(2):166-170
Remains of 15 hominids were recovered within a Mousterian archaeological context in the cave of Qafzeh, Israel. Dated to ca. 95 kyr BP, this skeletal material has been crucial for understanding biological, chronological, and cultural aspects of anatomically modern ancient Homo sapiens. The high proportion of children (N = 8) in Qafzeh Cave is unique among Middle Palaeolithic sites and encourages the search for skeletal evidence of disease and trauma. We report on the case of one child, Qafzeh 12, ca. 3 years old (according to modern human reference standards), who manifests some outstanding skeletal abnormalities that indicate hydrocephalus. 相似文献
4.
Michael D. Petraglia Abdullah Alsharekh Paul Breeze Chris Clarkson Rémy Crassard Nick A. Drake Huw S. Groucutt Richard Jennings Adrian G. Parker Ash Parton Richard G. Roberts Ceri Shipton Carney Matheson Abdulaziz al-Omari Margaret-Ashley Veall 《PloS one》2012,7(11)
The Arabian Peninsula is a key region for understanding hominin dispersals and the effect of climate change on prehistoric demography, although little information on these topics is presently available owing to the poor preservation of archaeological sites in this desert environment. Here, we describe the discovery of three stratified and buried archaeological sites in the Nefud Desert, which includes the oldest dated occupation for the region. The stone tool assemblages are identified as a Middle Palaeolithic industry that includes Levallois manufacturing methods and the production of tools on flakes. Hominin occupations correspond with humid periods, particularly Marine Isotope Stages 7 and 5 of the Late Pleistocene. The Middle Palaeolithic occupations were situated along the Jubbah palaeolake-shores, in a grassland setting with some trees. Populations procured different raw materials across the lake region to manufacture stone tools, using the implements to process plants and animals. To reach the Jubbah palaeolake, Middle Palaeolithic populations travelled into the ameliorated Nefud Desert interior, possibly gaining access from multiple directions, either using routes from the north and west (the Levant and the Sinai), the north (the Mesopotamian plains and the Euphrates basin), or the east (the Persian Gulf). The Jubbah stone tool assemblages have their own suite of technological characters, but have types reminiscent of both African Middle Stone Age and Levantine Middle Palaeolithic industries. Comparative inter-regional analysis of core technology indicates morphological similarities with the Levantine Tabun C assemblage, associated with human fossils controversially identified as either Neanderthals or Homo sapiens. 相似文献
5.
William J. Rink Norbert Mercier Du?an Mihailovi? Mike W. Morley Jeroen W. Thompson Mirjana Roksandic 《PloS one》2013,8(2)
Newly obtained ages, based on electron spin resonance combined with uranium series isotopic analysis, and infrared/post-infrared luminescence dating, provide a minimum age that lies between 397 and 525 ka for the hominin mandible BH-1 from Mala Balanica cave, Serbia. This confirms it as the easternmost hominin specimen in Europe dated to the Middle Pleistocene. Inferences drawn from the morphology of the mandible BH-1 place it outside currently observed variation of European Homo heidelbergensis. The lack of derived Neandertal traits in BH-1 and its contemporary specimens in Southeast Europe, such as Kocabaş, Vasogliano and Ceprano, coupled with Middle Pleistocene synapomorphies, suggests different evolutionary forces acting in the east of the continent where isolation did not play such an important role during glaciations. 相似文献
6.
Homo erectus is the first hominin species with a truly cosmopolitan distribution and resembles recent humans in its broad spatial distribution. The microevolutionary events associated with dispersal and local adaptation may have produced similar population structure in both species. Understanding the evolutionary population dynamics of H. erectus has larger implications for the emergence of later Homo lineages in the Middle Pleistocene. Quantitative genetics models provide a means of interrogating aspects of long-standing H. erectus population history narratives. For the current study, cranial fossils were sorted into six major palaeodemes from sites across Africa and Asia spanning 1.8–0.1 Ma. Three-dimensional shape data from the occipital and frontal bones were used to compare intraspecific variation and test evolutionary hypotheses. Results indicate that H. erectus had higher individual and group variation than Homo sapiens, probably reflecting different levels of genetic diversity and population history in these spatially disperse species. This study also revealed distinct evolutionary histories for frontal and occipital bone shape in H. erectus, with a larger role for natural selection in the former. One scenario consistent with these findings is climate-driven facial adaptation in H. erectus, which is reflected in the frontal bone through integration with the orbits. 相似文献
7.
《PloS one》2014,9(7)
The first arrivals of hominin populations into Eurasia during the Early Pleistocene are currently considered to have occurred as short and poorly dated biological dispersions. Questions as to the tempo and mode of these early prehistoric settlements have given rise to debates concerning the taxonomic significance of the lithic assemblages, as trace fossils, and the geographical distribution of the technological traditions found in the Lower Palaeolithic record. Here, we report on the Barranc de la Boella site which has yielded a lithic assemblage dating to ∼1 million years ago that includes large cutting tools (LCT). We argue that distinct technological traditions coexisted in the Iberian archaeological repertoires of the late Early Pleistocene age in a similar way to the earliest sub-Saharan African artefact assemblages. These differences between stone tool assemblages may be attributed to the different chronologies of hominin dispersal events. The archaeological record of Barranc de la Boella completes the geographical distribution of LCT assemblages across southern Eurasia during the EMPT (Early-Middle Pleistocene Transition, circa 942 to 641 kyr). Up to now, chronology of the earliest European LCT assemblages is based on the abundant Palaeolithic record found in terrace river sequences which have been dated to the end of the EMPT and later. However, the findings at Barranc de la Boella suggest that early LCT lithic assemblages appeared in the SW of Europe during earlier hominin dispersal episodes before the definitive colonization of temperate Eurasia took place. 相似文献
8.
A new partial cranium (UW 88-886) of the Plio-Pleistocene baboon Papio angusticeps from Malapa is identified, described and discussed. UW 88-886 represents the only non-hominin primate yet recovered from Malapa and is important both in the context of baboon evolution as well as South African hominin site biochronology. The new specimen may represent the first appearance of modern baboon anatomy and coincides almost perfectly with molecular divergence date estimates for the origin of the modern P. hamadryas radiation. The fact that the Malapa specimen is dated between ~2.026–2.36 million years ago (Ma) also has implications for the biochronology of other South African Plio-Pleistocene sites where P. angusticeps is found. 相似文献
9.
Dorota Wojtczak 《L'Anthropologie》2015,119(5):610-658
Recent research reveals that the production of elongated blanks using different flaking techniques is an important part of the Early Middle Palaeolithic (EMP) industries in Near Eastern sites dated between 250 and 160 ka ago. The excavation at Hummal located in the arid steppe of Central Syria produced blade industries located in the stratigraphy between the Yabrudian and Levalloiso-Mousterian and this sequence is dated to about 200 ky. This paper presents data on the Hummalian culture from its discovery in 1980 to the systematic excavation of in situ archaeological layers between 1997 and 2010. Today the Hummalian industry is seen as a single, but very complex reduction strategy related to both the Laminar and the Levallois-like system of debitage. It is a unique reduction system containing diverse types of core volume management within which blanks of different morphologies have been produced from a single core using a direct, hammer percussion. Though, the Hummalian still shares many techno-typological similarities with the others laminar, lithic assemblages found on the Early Middle Palaeolithic sites in Levant, the same chronological and stratigraphical position and similar land-use strategies. As the EMP blade industries in Levant are preceded by the Acheulo-Yabrudian techno-complexes, the shift between both these lithic complexes, already seen in their chronological boundary, may also imply a technological discontinuity and possibly differing human populations. 相似文献
10.
Matteo Romandini Marco Peresani Véronique Laroulandie Laure Metz Andreas Pastoors Manuel Vaquero Ludovic Slimak 《PloS one》2014,9(7)
To contribute to have a better understanding of the symbolic or not use of certain items by Neanderthals, this work presents new evidence of the deliberate removal of raptor claws occurred in Mediterranean Europe during the recent phases of the Mousterian. Rio Secco Cave in the north-east of Italy and Mandrin Cave in the Middle Rhône valley have recently produced two golden eagle pedal phalanges from contexts not younger than 49.1–48.0 ky cal BP at Rio Secco and dated around 50.0 ky cal BP at Mandrin. The bones show cut-marks located on the proximal end ascribable to the cutting of the tendons and the incision of the cortical organic tissues. Also supported by an experimental removal of large raptor claws, our reconstruction explains that the deliberate detachment occurred without damaging the claw, in a way comparable at a general level with other Mousterian contexts across Europe. After excluding that these specimens met the nutritional requirements for human subsistence, we discuss the possible implications these findings perform in our current knowledge of the European Middle Palaeolithic context. 相似文献
11.
In 1995-1996 two isolated hominin lower incisors were found at the middle Pleistocene site of Boxgrove in England, with Lower Palaeolithic archaeology. Boxgrove 2 is a permanent lower right central incisor and Boxgrove 3 a permanent lower left lateral incisor. They were found separately, but close to one another and appear to belong to the same individual. The Boxgrove 1 tibia discovered in 1993 came from a different stratigraphic context and is thus believed to represent a different individual. This paper describes the morphology of the incisors, which is similar to other middle Pleistocene hominin specimens and, as with the tibia, suggests that they could be assigned to Homo heidelbergensis (recognising that the taxonomic status of this species is still a matter of debate). The incisors show substantial attrition associated with secondary dentine deposition in the pulp chamber and clearly represent an adult. They also show extensive patterns of non-masticatory scratches on the labial surfaces of both crown and root, including some marks which may have been made postmortem. The roots were exposed in life on their labial sides by a large dehiscence, extending almost to the root apex. This is demonstrated by deposits of calculus, polishing, and scratching on the exposed surfaces. The dehiscence may have been caused by repeated trauma to the gingivae or remodelling of the tooth-supporting tissues in response to large forces applied to the front of the dentition. 相似文献
12.
María Calvi?o-Cancela Roi Méndez-Rial Javier Reguera-Salgado Julio Martín-Herrero 《PloS one》2014,9(7)
Effective management of invasive plants requires a precise determination of their distribution. Remote sensing techniques constitute a promising alternative to field surveys and hyperspectral sensors (also known as imaging spectrometers, with a large number of spectral bands and high spectral resolution) are especially suitable when very similar categories are to be distinguished (e.g. plant species). A main priority in the development of this technology is to lower its cost and simplify its use, so that its demonstrated aptitude for many environmental applications can be truly realized. With this aim, we have developed a system for hyperspectral imaging (200 spectral bands in the 380–1000 nm range and circa 3 nm spectral resolution) operated on board ultralight aircraft (namely a gyrocopter), which allows a drastic reduction of the running costs and operational complexity of image acquisition, and also increases the spatial resolution of the images (circa 5–8 pixels/m2 at circa 65 km/h and 300 m height). The detection system proved useful for the species tested (Acacia melanoxylon, Oxalis pes-caprae, and Carpobrotus aff. edulis and acinaciformis), with user’s and producer’s accuracy always exceeding 90%. The detection accuracy reported corresponds to patches down to 0.125 m2 (50% of pixels 0.5×0.5 m in size), a very small size for many plant species, making it very effective for initial stages of invasive plant spread. In addition, its low operating costs, similar to those of a 4WD ground vehicle, facilitate frequent image acquisition. Acquired images constitute a permanent record of the status of the study area, with great amount of information that can be analyzed in the future for other purposes, thus greatly facilitating the monitoring of natural areas at detailed spatial and temporal scales for improved management. 相似文献
13.
The Qafzeh VI skull was found in 1934 by R. Neuville in a Mousterian industry level. It belonged to an adult man. The present study shows that, for the greatest part of its characteristics—high cranial vault, upright frontal, orthognathism, presence of a canine fossa, shape of the orbits, etc.—the Qafzeh man is closer to Upper Paleolithic Homo sapiens than to Neandertal man. Some of its traits, the supra-orbital torus for example, recall the Neandertalian characteristics but without ever attaining the development observed on the latter. 相似文献
14.
The C-terminal region of Escherichia coli UvrC contributes to the flexibility of the UvrABC nucleotide excision repair system
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Verhoeven EE van Kesteren M Turner JJ van der Marel GA van Boom JH Moolenaar GF Goosen N 《Nucleic acids research》2002,30(11):2492-2500
Nucleotide excision repair in Escherichia coli involves formation of the UvrB–DNA complex and subsequent DNA incisions on either site of the damage by UvrC. In this paper, we studied the incision of substrates with different damages in varying sequence contexts. We show that there is not always a correlation between the incision efficiency and the stability of the UvrB–DNA complex. Both stable and unstable UvrB–DNA complexes can be efficiently incised. However some lesions that give rise to stable UvrB–DNA complexes do result in a very low incision. We present evidence that this poor incision is due to sterical hindrance of the damage itself. In its C-terminal region UvrC contains two helix–hairpin–helix (HhH) motifs. Mutational analysis shows that these motifs constitute one functional unit, probably folded as one structural unit; the (HhH)2 domain. This (HhH)2 domain was previously shown to be important for the 5′ incision on a substrate containing a (cis-Pt)·GG adduct, but not for 3′ incision. Here we show that, mainly depending on the sequence context of the lesion, the (HhH)2 domain can be important for 3′ and/or 5′ incision. We propose that the (HhH)2 domain stabilises specific DNA structures required for the two incisions, thereby contributing to the flexibility of the UvrABC repair system. 相似文献
15.
Michel Toussaint Anthony J. Olejniczak Pierre Cattelain Claire Letourneux 《Journal of human evolution》2010,58(1):56-67
A human lower right deciduous second molar was discovered in 1984 at the entrance of Trou de l'Abîme at Couvin (Belgium). In subsequent years the interpretation of this fossil remained difficult for various reasons: (1) the lack of taxonomically diagnostic elements which would support its attribution to either Homo (sapiens) neanderthalensis or H. s. sapiens; (2) the absence of any reliable chronostratigraphic interpretation of the sedimentary sequence of the site; (3) the contradiction between archaeological interpretations, which attributed the lithic industry to a transitional facies between the Middle and Early Upper Palaeolithic, and the radiocarbon date of 46,820 ± 3,290 BP obtained from animal bone remains associated with the tooth and the flint tools.Thanks to recent progress regarding these three aspects, the tooth from Trou de l'Abîme may now be studied in detail. Analyses of the morphology and enamel thickness of the fossil yielded diagnostic characters consistent with an attribution to Neandertals. Re-examination of the lithic industry of Couvin shows that it corresponds to the late Middle Palaeolithic rather than a transitional facies. Furthermore, a new analysis of the site stratigraphy indicates that the unit situated above the archaeological layer in which the tooth was found is probably a palaeosol of brown soil type. Comparison with the regional cave sequences as well as with the reference sequence from the Belgian loess belt tends to show that the most recent palaeosol of this type is dated between 42,000 and 40,000 BP. This is consistent with both a recently obtained AMS result at 44,500 BP and the published conventional date. 相似文献
16.
Pinhasi R Gasparian B Wilkinson K Bailey R Bar-Oz G Bruch A Chataigner C Hoffmann D Hovsepyan R Nahapetyan S Pike AW Schreve D Stephens M 《Journal of human evolution》2008,55(5):803-816
The territory of present day Armenia is a geographic contact zone between the Near East and the northern Caucasus. Armenian Middle and Upper Paleolithic records are both few and patchy as a result of the historical paucity of systematic archaeological research in the country. Consequently, it is currently difficult to correlate the Armenian Middle and Upper Paleolithic records with those from other neighboring regions. We present new archaeological and chronometric data (luminescence, U-Th, and 14C) from our ongoing research at Hovk 1 Cave in northeast Armenia. We discuss in particular two activity phases in Hovk 1 Cave for which we have outline chronometric data: (1) an early Middle Paleolithic occupational phase, dated by optically stimulated luminescence (OSL) to 104 ± 9.8 ka BPOSL; and (2) a Paleolithic occupational phase characterized by microlithic flakes dated by AMS 14C to 39,109 ± 1,324 calibrated years BPHulu. The two phases are separated by a hiatus in hominin occupation corresponding to MIS 4 and an episode in early MIS 3. These chronometric data, taken together with the preliminary paleoenvironmental reconstruction of the Hovk 1 Cave and environment, suggest that these activity phases represent short-lived and seasonal use of the cave presumably by small groups of hunters during episodes of mild climate. Neither tool manufacture nor butchery appears to have taken place within the cave, and consequently, the archaeological record included, for the most part, finished tools and blanks. We address the chronology and techno-typological aspects of Hovk 1 lithics in relation to: (1) the Paleolithic records of Armenia, and (2) the broader interregional context of early Middle Paleolithic hominin occupation and the Middle-Upper Paleolithic transition in the Caucasus. 相似文献
17.
Monique Michels Lucinéia Gainski Danieslki Andriele Vieira Drielly Florentino Dhébora Dall’Igna Letícia Galant Beatriz Sonai Francieli Vuolo Franciele Mina Bruna Pescador Diogo Dominguini Tatiana Barichello Jo?o Quevedo Felipe Dal-Pizzol Fabrícia Petronilho 《Molecular medicine (Cambridge, Mass.)》2015,21(1):219-226
Sepsis-associated encephalopathy (SAE) is associated with an increased rate of morbidity and mortality. It is not understood what the exact mechanism is for the brain dysfunction that occurs in septic patients, but brain inflammation and oxidative stress are a possible theory. Such events can occur through the alteration of molecules that perpetuate the inflammatory response. Thus, it is possible to postulate that CD40 may be involved in this process. The aim of this work is to evaluate the role of CD40–CD40L pathway activation in brain dysfunction associated with sepsis in an animal model. Microglia activation induces the upregulation of CD40–CD40L, both in vitro and in vivo. The inhibition of microglia activation decreases levels of CD40–CD40L in the brain and decreases brain inflammation, oxidative damage and blood brain barrier dysfunction. Despite this, anti-CD40 treatment does not improve mortality in this model. However, it is able to improve long-term cognitive impairment in sepsis survivors. In conclusion, there is a major involvement of the CD40–CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis. 相似文献
18.
N Doti C Reuther P L Scognamiglio A M Dolga N Plesnila M Ruvo C Culmsee 《Cell death & disease》2014,5(1):e993
Delayed neuronal cell death largely contributes to the progressive infarct development and associated functional impairments after cerebral ischemia or brain trauma. Previous studies exposed a key role for the interaction of the mitochondrial protein apoptosis-inducing factor (AIF) and cytosolic cyclophilin A (CypA) in pathways of programmed cell death in neurons in vitro and in vivo. These studies suggested that pro-apoptotic activities of AIF, such as its translocation to the nucleus and subsequent DNA degradation, depend on the physical interaction of AIF with CypA. Hence, this protein complex may represent a new pharmacological target for inhibiting the lethal action of AIF on the brain tissue. In this study, we show that the AIF amino-acid residues 370–394 mediate the protein complex formation of AIF with CypA. The synthetic AIF(370–394) peptide inhibited AIF/CypA complex formation in vitro by binding CypA with a KD of 12 μM. Further, the peptide exerted pronounced neuroprotective effects in a model of glutamate-induced oxidative stress in cultured HT-22 cells. In this model system of AIF-dependent cell death, the AIF(370–394) peptide preserved mitochondrial integrity, as detected by measurements of the mitochondrial membrane potential and quantification of mitochondrial fragmentation. Further, the AIF(370–394) peptide inhibited perinuclear accumulation of fragmented mitochondria, mitochondrial release of AIF to the nucleus and glutamate-induced cell death to a similar extent as CypA-siRNA. These data indicate that the targeting of the AIF-CypA axis is an effective strategy of neuroprotection. 相似文献
19.
Carlo Peretto Julie Arnaud Jacopo Moggi-Cecchi Giorgio Manzi Sébastien Nomade Alison Pereira Christophe Falguères Jean-Jacques Bahain Dominique Grimaud-Hervé Claudio Berto Benedetto Sala Giuseppe Lembo Brunella Muttillo Rosalia Gallotti Ursula Thun Hohenstein Carmela Vaccaro Mauro Coltorti Marta Arzarello 《PloS one》2015,10(10)
Isernia La Pineta (south-central Italy, Molise) is one of the most important archaeological localities of the Middle Pleistocene in Western Europe. It is an extensive open-air site with abundant lithic industry and faunal remains distributed across four stratified archaeosurfaces that have been found in two sectors of the excavation (3c, 3a, 3s10 in sect. I; 3a in sect. II). The prehistoric attendance was close to a wet environment, with a series of small waterfalls and lakes associated to calcareous tufa deposits. An isolated human deciduous incisor (labelled IS42) was discovered in 2014 within the archaeological level 3 coll (overlying layer 3a) that, according to new 40Ar/39Ar measurements, is dated to about 583–561 ka, i.e. to the end of marine isotope stage (MIS) 15. Thus, the tooth is currently the oldest human fossil specimen in Italy; it is an important addition to the scanty European fossil record of the Middle Pleistocene, being associated with a lithic assemblage of local raw materials (flint and limestone) characterized by the absence of handaxes and reduction strategies primarily aimed at the production of small/medium-sized flakes. The faunal assemblage is dominated by ungulates often bearing cut marks. Combining chronology with the archaeological evidence, Isernia La Pineta exhibits a delay in the appearance of handaxes with respect to other European Palaeolithic sites of the Middle Pleistocene. Interestingly, this observation matches the persistence of archaic morphological features shown by the human calvarium from the Middle Pleistocene site of Ceprano, not far from Isernia (south-central Italy, Latium). In this perspective, our analysis is aimed to evaluate morphological features occurring in IS42. 相似文献
20.
The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase 总被引:1,自引:0,他引:1
Guan X Madabushi A Chang DY Fitzgerald ME Shi G Drohat AC Lu AL 《Nucleic acids research》2007,35(18):6207-6218
Human (h) DNA repair enzyme thymine DNA glycosylase (hTDG) is a key DNA glycosylase in the base excision repair (BER) pathway that repairs deaminated cytosines and 5-methyl-cytosines. The cell cycle checkpoint protein Rad9–Rad1–Hus1 (the 9-1-1 complex) is the surveillance machinery involved in the preservation of genome stability. In this study, we show that hTDG interacts with hRad9, hRad1 and hHus1 as individual proteins and as a complex. The hHus1 interacting domain is mapped to residues 67–110 of hTDG, and Val74 of hTDG plays an important role in the TDG–Hus1 interaction. In contrast to the core domain of hTDG (residues 110–308), hTDG(67–308) removes U and T from U/G and T/G mispairs, respectively, with similar rates as native hTDG. Human TDG activity is significantly stimulated by hHus1, hRad1, hRad9 separately, and by the 9-1-1 complex. Interestingly, the interaction between hRad9 and hTDG, as detected by co-immunoprecipitation (Co-IP), is enhanced following N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) treatment. A significant fraction of the hTDG nuclear foci co-localize with hRad9 foci in cells treated with methylating agents. Thus, the 9-1-1 complex at the lesion sites serves as both a damage sensor to activate checkpoint control and a component of the BER. 相似文献