共查询到20条相似文献,搜索用时 62 毫秒
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《Cell cycle (Georgetown, Tex.)》2013,12(23):4622-4626
Deregulated expression of Myc under the control of an immunoglobulin enhancer induces lymphoma formation in mice. The development of lymphomas is limited by TGFβ-dependent senescence and high levels of Myc expression are continuously required to antagonize senescence. The biological processes underlying senescence are not fully resolved. We report here a comprehensive analysis of TGFβ-dependent alterations in gene expression when the Myc transgene is switched off. Our data show that Myc-induced target genes are downregulated in a TGFβ-independent manner. In contrast, TGFβ is required to upregulate a broad spectrum of genes that are characteristic for differenT-cell lineages when Myc is turned off. The analysis reveals a significant overlap between these Myc-repressed genes with genes that are targets of polycomb repressive complexes in embryonic stem cells. Therefore, TGFβ-dependent senescence is associated with gene expression patterns indicative of abortive cellular differentiation along several lineages. 相似文献
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Marinkovic D Marinkovic T Kokai E Barth T Möller P Wirth T 《Nucleic acids research》2004,32(18):5368-5378
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Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis 总被引:12,自引:0,他引:12
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Li F Wang Y Zeller KI Potter JJ Wonsey DR O'Donnell KA Kim JW Yustein JT Lee LA Dang CV 《Molecular and cellular biology》2005,25(14):6225-6234
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Myc represses transcription through recruitment of DNA methyltransferase corepressor 总被引:1,自引:0,他引:1
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Brenner C Deplus R Didelot C Loriot A Viré E De Smet C Gutierrez A Danovi D Bernard D Boon T Pelicci PG Amati B Kouzarides T de Launoit Y Di Croce L Fuks F 《The EMBO journal》2005,24(2):336-346