The human placenta exhibits a unique transcriptomic void

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PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1

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LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs

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DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation

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The function of classical and alternative non‐homologous end‐joining pathways in the fusion of dysfunctional telomeres

Repair of DNA double‐stranded breaks (DSBs) is crucial for the maintenance of genome stability. DSBs are repaired by either error prone non‐homologous end‐joining (NHEJ) or error‐free homologous recombination. NHEJ precedes either by a classic, Lig4‐dependent process (C‐NHEJ) or an alternative, Lig4‐independent one (A‐NHEJ). Dysfunctional telomeres arising either through natural attrition due to telomerase deficiency or by removal of telomere‐binding proteins are recognized as DSBs. In this report, we studied which end‐joining pathways are required to join dysfunctional telomeres. In agreement with earlier studies, depletion of Trf2 resulted in end‐to‐end chromosome fusions mediated by the C‐NHEJ pathway. In contrast, removal of Tpp1–Pot1a/b initiated robust chromosome fusions that are mediated by A‐NHEJ. C‐NHEJ is also dispensable for the fusion of naturally shortened telomeres. Our results reveal that telomeres engage distinct DNA repair pathways depending on how they are rendered dysfunctional, and that A‐NHEJ is a major pathway to process dysfunctional telomeres.     

Stn1-Ten1 and Taz1 independently promote replication of subtelomeric fragile sequences in fission yeast

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Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma

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Cellular uptake of nickel by NikR is regulated by phase separation

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Extensive de novo activity stabilizes epigenetic inheritance of CG methylation in Arabidopsis transposons

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The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation

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Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation

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The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER

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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

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PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

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Histone H3K79 methylation by DOT1L promotes Aurora B localization at centromeres in mitosis

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Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency

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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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Single-nucleus resolution mapping of the adult C. elegans and its application to elucidate inter- and trans-generational response to alcohol

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