CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

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Active experience,not time,determines within-day representational drift in dorsal CA1

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The cephalic phase of insulin release is modulated by IL-1β

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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1

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Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells

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The CNS mononuclear phagocyte system in health and disease

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Catalytic cycling of human mitochondrial Lon protease

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The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48

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Lon degrades stable substrates slowly but with enhanced processivity,redefining the attributes of a successful AAA+ protease

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DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells

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A unified atlas of CD8 T cell dysfunctional states in cancer and infection

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SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages

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Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes

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IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production

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Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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Definition of a small core transcriptional circuit regulated by AML1-ETO

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1

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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

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