Identification of a second Klotho interaction site in the C terminus of FGF23

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Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

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TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria

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Cryo-EM structure of the cytosolic AhR complex

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CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b−CD103+ DCs

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The Sar1 GTPase is dispensable for COPII-dependent cargo export from the ER

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Transmembrane Coordination of Preprotein Recognition and Motor Coupling by the Mitochondrial Presequence Receptor Tim50

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Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1

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The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state

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UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1

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The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue

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The switch from client holding to folding in the Hsp70/Hsp90 chaperone machineries is regulated by a direct interplay between co-chaperones

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Increased fidelity of protein synthesis extends lifespan

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Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23

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The Circadian Clock Gene Circuit Controls Protein and Phosphoprotein Rhythms in Arabidopsis thaliana

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Parinarioidins A-B,unprecedented flavonoids from the bark of Brosimum parinarioides Ducke

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Predicting Successful Generation and Inhibition of Seizure-like Afterdischarges and Mapping Their Seizure Networks Using fMRI

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Opto-katanin,an optogenetic tool for localized,microtubule disassembly

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Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

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Large-scale genome sequencing reveals the driving forces of viruses in microalgal evolution

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