共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
Hatcher CJ Kim MS Mah CS Goldstein MM Wong B Mikawa T Basson CT 《Developmental biology》2001,230(2):177-188
3.
4.
5.
6.
7.
8.
9.
10.
11.
TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《American journal of human genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Andreou AM Pauws E Jones MC Singh MK Bussen M Doudney K Moore GE Kispert A Brosens JJ Stanier P 《American journal of human genetics》2007,81(4):700-712
12.
13.
14.
Hammer S Toenjes M Lange M Fischer JJ Dunkel I Mebus S Grimm CH Hetzer R Berger F Sperling S 《Journal of cellular biochemistry》2008,104(3):1022-1033
15.
16.
17.
18.
19.
20.
Brown DD Martz SN Binder O Goetz SC Price BM Smith JC Conlon FL 《Development (Cambridge, England)》2005,132(3):553-563
Members of the T-box family of proteins play a fundamental role in patterning the developing vertebrate heart; however, the precise cellular requirements for any one family member and the mechanism by which individual T-box genes function remains largely unknown. In this study, we have investigated the cellular and molecular relationship between two T-box genes, Tbx5 and Tbx20. We demonstrate that blocking Tbx5 or Tbx20 produces phenotypes that display a high degree of similarity, as judged by overall gross morphology, molecular marker analysis and cardiac physiology, implying that the two genes are required for and have non-redundant functions in early heart development. In addition, we demonstrate that although co-expressed, Tbx5 and Tbx20 are not dependent on the expression of one another, but rather have a synergistic role during early heart development. Consistent with this proposal, we show that TBX5 and TBX20 can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development, thus providing the first evidence for direct interaction between members of the T-box gene family. 相似文献