网络环境下医学图书馆服务模式的演变发展探讨

随着网络化技术的发展,医学图书馆的信息服务模式也在进行着不断的转变.本文分析了医学图书馆的多元化发展趋势:医学图书馆馆藏媒介的多元化医学图书馆读者信息需求的多元化、医学图书馆信息服务方式的多元化,探讨了在运用新的技术手段和技术方法下医学图书馆服务模式的演变及新模式下的图书馆人员结构问题.     

新时期医院图书馆的发展研究

医院图书馆经费不足,规模较小,馆藏资源不足,人员结构参差不齐,服务内容有限,无法满足读者对医学信息多样化的需求,以及面对医院新时期改革的机遇与挑战,提出了医院图书馆的转型和发展策略。     

医学图书馆的网络信息资源利用

网络信息日益深入我们的生活,为我们获取知识提供了极大的便利,现实表明医学图书馆网络信息资源的开发与利用,图书资源与网络信息资源结合的优势组合,已极大地拓展广大医务工作者及相关人员的知识领域。如何借助信息技术,依托网络环境,转变单一的馆藏发展模式,选取网上信息资源拓展馆藏,更深入地开发网上信息资源供读者利用是本文论述的目的。     

医学图书馆的网络信息资源利用

网络信息日益深入我们的生活,为我们获取知识提供了极大的便利,现实表明医学图书馆网络信息资源的开发与利用,图书资源与网络信息资源结合的优势组合,已极大地拓展广大医务工作者及相关人员的知识领域.如何借助信息技术,依托网络环境,转变单一的馆藏发展模式,选取网上信息资源拓展馆藏,更深入地开发网上信息资源供读者利用是本文论述的目的.     

NIH library资源建设与服务研究

National Institutes of Health(美国国立卫生研究院,简称NIH)是国家级医学研究机构。NIH library是为NIH成员提供信息资源及服务的主要机构。本文从发展历史、馆藏发展策略、资源建设经费来源、信息资源揭示和整合、用户需求分析、信息服务5个方面调研分析了NIH library资源建设和服务现状,以期为国内医学图书馆提供借鉴。     

馆藏图书中微生物的研究

通过对馆藏图书微生物的研究,结果表明;被污染的图书资料中主要优势菌为霉菌,其次为细菌。安徽大学图书馆和安徽省图书馆以及其楼层之间的微生物数量相差较大。     

网络环境下的医学图书馆

随着科学技术的迅猛发展,医学技术高度分化、高度综合,正向着纵深发展。新理论、新技术不断产生,边缘学科,交叉学科也纷纷涌现,各种数据库、网上全文检索系统广泛应用使医学图书馆走上网络化、虚拟化道路。如今的医学图书馆作为医学信息的搜集者、整理者,在网络环境下扮演着网络技术员和信息导航员的双重角色。为了准确、快捷查找出国内外先进的、有价值的医学文献信息提供给医护人员,要求医学图书馆人不仅要熟练掌握图书情报专业知识而且要了解、熟悉医学方面、外语方面、生物学方面、计算机方面的知识。只有不断的更新专业知识结构,才能提供完美的信息服务的同时完善医学图书馆事业。     

现代医学图书馆的网页制作

本文通过实践,结合医学图书馆的特点,从医学图书馆网页设计应遵循的指导性、特色性、实用性、艺术性等原则,网页内容组织的要素分析,主页的设计、文本的输入和美化、图像的嵌入、背景音乐的设置、视频文件的嵌入、网页的链接等网页元素的制作方法等几个方面,阐述了现代化的医学图书馆的网页制作,并谈了一些制作体会。     

现代医学图书馆的网页制作

本文通过实践,结合医学图书馆的特点,从医学图书馆网页设计应遵循的指导性、特色性、实用性、艺术性等原则,网页内容组织的要素分析,主页的设计、文本的输入和美化、图像的嵌入、背景音乐的设置、视频文件的嵌入、网页的链接等网页元素的制作方法等几个方面,阐述了现代化的医学图书馆的网页制作,并谈了一些制作体会.     

信息时代高校图书馆读者服务工作的发展对策研究

介绍了信息时代高校图书馆读者服务工作的发展趋势,分析了当前这项工作中存在的一些问题,并提出了解决这些问题的相应对策,如转变服务观念、加强图书馆技术设备建设、加强馆藏信息资源建设、创新读者服务内容、实行开放服务方式以及提高读者服务人员素质等。     

The Medical Library Service of the College of Physicians and Surgeons of British Columbia

A unique provincial medical library service has been established in British Columbia. Under the direction of professional librarians, the central library in Vancouver is building an extensive, largely clinical collection while 30 smaller branch libraries in hospitals throughout the province are establishing basic, up-to-date collections. Financial support comes from an annual fee of $25.00 per doctor paid to the College of Physicians and Surgeons of British Columbia. Photoduplication, mail and telephone services meet many reference needs. Reading is vital to continuing medical education. The library works closely with the University of British Columbia''s Department of Continuing Medical Education to bring current medical knowledge to every doctor in British Columbia.     

Using GIS to establish a public library consumer health collection

BACKGROUND: Learning the exact demographic characteristics of a neighborhood in which a public library serves, assists the collection development librarian in building an appropriate collection. Gathering that demographic information can be a lengthy process, and then formatting the information for the neighborhood in question becomes arduous.As society ages and the methods for health care evolve, people may take charge of their own health. With this prospectus, public libraries should consider creating a consumer health collection to assist the public in their health care needs. Using neighborhood demographic information can inform the collection development librarians as to the dominant age groups, sex, and races within the neighborhood. With this information, appropriate consumer health materials may be assembled in the public library. METHODS: In order to visualize the demographics of a neighborhood, the computer program ArcView GIS (geographic information systems) was used to create maps for specified areas. The neighborhood data was taken from the U.S. Census Department's annual census and library addresses were accumulated through a free database. After downloading the census block information from http://www.census.gov/geo/www/tiger/ the data was manipulated with ArcView GIS and queried to produce maps displaying the requested neighborhood demographics to view in respect to libraries. RESULTS: ArcView GIS produced maps displaying public libraries and requested demographics. After viewing the maps the collection development librarian can see exactly what populations are served by the library and adjust the library's collection accordingly. CONCLUSIONS: ArcView GIS can be used to produce maps displaying the communities that libraries serve, spot boundaries, be it "man-made or natural," that exist prohibiting customer service, and assist collection development librarians in justifying their purchases for a dedicated consumer health collection or resources in general.     

Large-scale identification of expressed sequence tags involved in rice and rice blast fungus interaction

To better understand the molecular basis of the defense response against the rice blast fungus (Magnaporthe grisea), a large-scale expressed sequence tag (EST) sequencing approach was used to identify genes involved in the early infection stages in rice (Oryza sativa). Six cDNA libraries were constructed using infected leaf tissues harvested from 6 conditions: resistant, partially resistant, and susceptible reactions at both 6 and 24 h after inoculation. Two additional libraries were constructed using uninoculated leaves and leaves from the lesion mimic mutant spl11. A total of 68,920 ESTs were generated from 8 libraries. Clustering and assembly analyses resulted in 13,570 unique sequences from 10,934 contigs and 2,636 singletons. Gene function classification showed that 42% of the ESTs were predicted to have putative gene function. Comparison of the pathogen-challenged libraries with the uninoculated control library revealed an increase in the percentage of genes in the functional categories of defense and signal transduction mechanisms and cell cycle control, cell division, and chromosome partitioning. In addition, hierarchical clustering analysis grouped the eight libraries based on their disease reactions. A total of 7,748 new and unique ESTs were identified from our collection compared with the KOME full-length cDNA collection. Interestingly, we found that rice ESTs are more closely related to sorghum (Sorghum bicolor) ESTs than to barley (Hordeum vulgare), wheat (Triticum aestivum), and maize (Zea mays) ESTs. The large cataloged collection of rice ESTs in this study provides a solid foundation for further characterization of the rice defense response and is a useful public genomic resource for rice functional genomics studies.     

Structure based function prediction of proteins using fragment library frequency vectors

The function of the protein is primarily dictated by its structure. Therefore it is far more logical to find the functional clues of the protein in its overall 3-dimensional fold or its global structure. In this paper, we have developed a novel Support Vector Machines (SVM) based prediction model for functional classification and prediction of proteins using features extracted from its global structure based on fragment libraries. Fragment libraries have been previously used for abintio modelling of proteins and protein structure comparisons. The query protein structure is broken down into a collection of short contiguous backbone fragments and this collection is discretized using a library of fragments. The input feature vector is frequency vector that counts the number of each library fragment in the collection of fragments by all-to-all fragment comparisons. SVM models were trained and optimised for obtaining the best 10-fold Cross validation accuracy for classification. As an example, this method was applied for prediction and classification of Cell Adhesion molecules (CAMs). Thirty-four different fragment libraries with sizes ranging from 4 to 400 and fragment lengths ranging from 4 to 12 were used for obtaining the best prediction model. The best 10-fold CV accuracy of 95.25% was obtained for library of 400 fragments of length 10. An accuracy of 87.5% was obtained on an unseen test dataset consisting of 20 CAMs and 20 NonCAMs. This shows that protein structure can be accurately and uniquely described using 400 representative fragments of length 10.     

Molecular diversity in engineered protein libraries

Engineered protein libraries, defined here as a collection of different mutant variants of a single specific protein, are intentionally designed to be rich in molecular diversity and can span ranges from as little as 400 different variants to greater than 10(12) members per library. The goal of engineering libraries is to generate new protein variants, identified upon screening, that possess desired novel properties. Exploitation of the natural organization of the genetic code has led to 'focused' libraries that are lower in overall complexity yet biased towards variants with preferred biophysical properties. An emerging trend, in which computational algorithms are blended with in vivo screens, is also leading towards greater and more rapid success in the field of protein design.     

Reference cDNA library facilities available from European sources

cDNA libraries are the cornerstone of efforts to identify the relatively small regions of genomes that are responsible for biological effects. Gene hunter seeking candidate genes, via a variety of approaches, ultimately focus on the cloning, sequencing, and expression of cDNAs. Assistance is now available to researchers in the form of genome programs, whose initial goals include assembly of a complete collection of expressed sequences derived from the genome of interest. The concept of reference sets of cDNA libraries is that the aims of genome programs are served most effectively by different laboratories working on a common set of high-quality arrayed cDNA libraries, using different experimental approaches, thereby reducing unnecessary duplication of effort, and maximizing the amount of information that one set of resources can provide.     

Applications of display technology in protein analysis

Display technology refers to a collection of methods for creating libraries of modularly coded biomolecules that can be screened for desired properties. It has become a routine tool for enriching molecular diversity and producing novel types of proteins. The combination of an ever-increasing variety of libraries of modularly coded protein complexxes with the development of innovative approaches to select a wide array of desired properties has facilitated large-scale analyses of protein-protein/protein-substrate interactions, rapid isolation of antibodies (or antibody mimetics) without immunization, and function-based protein analysis. Several practical and theoretical challenges remain to be addressed before display technology can be readily applied to proteomic studies.