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1.
Abdurrahim Kocyigit Ozcan Erel Mehmet S. Gurel Senel Avci Necmeddim Aktepe 《Biological trace element research》1998,65(3):271-281
The aim of this study was to measure the alterations in serum selenium (Se), copper (Cu), zinc (Zn), and iron (Fe) concentrations
and their carrier proteins, ceruloplasmin (Cp), transferrin (Tf) albumin, and related antioxidant enzyme activities, erythrocyte
Cu-Zn Superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities in patients with cutaneous
leishmaniasis (CL). Erythrocyte Cu-Zn SOD activities, serum Cu concentrations, and Cp levels were found to be significantly
higher in the patients group than those of controls. However, GSH-Px and CAT activities and Se, Zn, Fe, and Tf levels were
lower in patients than in the control subjects. There were positive important correlation’s between Cu-Zn SOD and Cp, Cu-Zn
SOD and Cu, Cp and Cu, GSH-Px and Se, and Fe and CAT in the patients group. Our results showed that serum essential trace
elements Se, Zn, Cu, and Fe concentrations and their related enzymes Cu-Zn SOD, GSH-Px, and CAT activities change in CL patients.
The changes may be a part of defense strategies of organism and are induced by the hormonelike substances. 相似文献
2.
A number of essential trace elements play a major role in various metabolic pathways. Selenium (Se), manganese (Mn), copper
(Cu), zinc (Zn), and iron (Fe) are essential trace elements that have been studied in many diseases, including autoimmune,
neurological, and psychiatric disorders. However, the findings of previous research on the status of trace elements in patients
with schizophrenia have been controversial. We studied these elements in patients with a DSM-IV diagnosis of schizophrenia
and compared them with sex- and age-matched healthy controls. Plasma Cu concentrations were significantly higher (p<0.01) and Mn and Fe concentrations were lower (p<0.05 and p<0.05, respectively) in schizophrenic patients than in controls. Se and Zn concentrations and protein levels did not differ
between patients and healthy controls. These observations suggest that alterations in essential trace elements Mn, Cu, and
Fe may play a role in the pathogenesis of schizophrenia. However, findings from trace element levels in schizophrenia show
a variety of results that are difficult to interpret. 相似文献
3.
In recent years, a great number of studies have investigated the possible role of trace elements in the etiology and pathogenesis
of rheumatoid arthritis (RA) and osteoartritis (OA). We studied synovial fluid and plasma concentrations of selenium (Se),
zinc (Zn), copper (Cu), and iron (Fe) in patients with RA and OA and compared them with sex- and age-matched healthy subjects.
Plasma albumin levels were measured as an index of nutritional status. Plasma Se, Cu, and Zn concentrations were determined
by atomic absorption spectrophotometry and Fe concentrations were determined by the colorimetric method. Although plasma and
synovial fluid Se concentration were found to be significantly lower (p<0.05, and p<0.05, respectively), Cu concentrations were significantly higher in patients with RA than those of healthy subjects and OA
(p<0.05 and p<0.05, respectively). There were no significant differences in plasma and synovial fluid Zn concentrations and albumin levels
among three groups (p>0.05). On the other hand, synovial fluid Cu and Fe concentrations were significantly higher in patients with OA than those
of healthy subjects (p<0.05). There was a significantly positive correlation between synovial fluid Se−Cu values and Zn−Fe values in patients with
RA. Our results showed that synovial fluid and plasma trace element concentrations, excluding Zn, change in inflammatory RA,
but not in OA. These alterations in trace element concentrations in inflammatory Ra might be a result on the changes of the
immunoregulatory cytokines. 相似文献
4.
The aim of the present study is to evaluate the status of plasma essential trace element selenium (Se), manganese (Mn), copper
(Cu), zinc (Zn), and iron (Fe) concentrations and the effect of these elements on oxidative status in patients with childhood
asthma. Plasma Se, Mn, Cu, and Zn concentrations were determined by atomic absorption spectrophotometry (AAS) and Fe concentrations,
malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined by the colorimetric method. The plasma MDA/TAC
ratio was calculated as an index of oxidative status. Plasma albumin levels were measured to determine nutritional status.
Plasma Fe concentrations, MDA levels and the MDA/TAC ratio were significantly higher (p<0.001, p<0.001, and p<0.01, respectively) and Se and Mn concentrations and TAC were lower (p<0.01, p<0.05, and p<0.01, respectively) in patients when compared to the healthy subjects. Plasma Zn, Cu, and albumin levels were not found to
be significantly different in patients and controls (p>0.05). There were positive relationships between plasma MDA and Fe (r=0.545, p<0.001) and TAC and Se (r=0.485, p<0.021), and a negative correlation between TAC and MDA values (r= −0.337, p<0.031) in patients with childhood asthma. However, there was no correlation between these trace elements and albumin content
in patient groups. These observations suggest that increased Fe and decreased Se concentrations in patients with childhood
asthma may be responsible for the oxidant/antioxidant imbalance. 相似文献
5.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
6.
The concentration of zinc, copper, selenium, albumin, and ceruloplasmin in blood plasma and the activity of superoxide dismutase
and glutathione peroxidase in erythrocytes were determined in a set of patients with idiopathic scoliosis (n=51). A significant decrease of selenium concentration (0.50±0.16 μmol/L) was found when compared with a control group (0.69±0.07
μmol/L) (p<0.01). The same levels of significance were found out for selenium levels corrected for albumin content. In a group of patients
with a curvature over 45° indicated for a surgical correction, the average plasma concentrations of selenium were significantly
lower (p<0.05) in comparison with a group of patients with a curvature below 45° treated conservatively.
The GSH-Px activity in erythrocytes was the same in both sets. In comparison with the controls, no significant differences
were revealed in all of the other parameters. The detection of the decreased blood plasma concentration of selenium has suggested
possible disturbance of well-proportioned distribution and of general optimal availability of selenium in the organism of
patients with idiopathic scoliosis with likely effects on the process of synthesis and maturation of collagen affecting the
axial skeleton stability. 相似文献
7.
Pasa S Kargin F Bildik A Seyrek K Ozbel Y Ozensoy S 《Biological trace element research》2003,94(2):141-147
The aim of this study was to determine the zinc, iron, copper, calcium, phosphorus, and magnesium levels in blood serum and
zinc and copper levels in hair of dogs with canine visceral leishmaniasis. The serum zinc and iron levels were found to be
significantly lower in diseased dogs than those of healthy controls. Serum copper levels were significantly higher, whereas
no significant differences were observed for calcium, phosphorus, and magnesium. There were no significant differences in
the zinc and copper levels in hair. Our results show that the serum zinc, iron, and copper levels are altered in canine leishmaniasis. 相似文献
8.
The aim of the present study is to evaluate the status of plasma essential trace elements selenium (Se), zinc (Zn), copper
(Cu), and iron (Fe) concentrations and their related acute-phase proteins, ceruloplasmin (Cp), ferritin, transferrin (Tf),
and albumin levels in patients with vivax malaria. Plasma Cu and Zn concentrations were determined by atomic absorption spectrometry
(AAS). Se concentrations were determined by graphite furnace AAS. Fe, Cp, Tf, and albumin levels were determined by colorimetric
methods. Plasma Se, Fe, and albumin levels were found to be significantly lower (p<0.01, p<0.001, and p<0.05, respectively) and Cu, Cp, and ferritin levels and Cu/Zn ratios were significantly higher (p<0.001, p<0.001, p<0.001, and p<0.05, respectively) in patients when compared with those of healthy subjects. Plasma, Tf, and Zn levels were not found to
be significantly different (p>0.05) in patients and controls. There were positive important correlations between Cu and Cp (r=0.908, p<0.001), Zn and albumin (r=0.633, p<0.001), and negative correlations between Fe and ferritin content (r=−0.521, p<0.05) and Fe and Tf (r=−0.616, p<0.01) in the patients group. Our findings demonstrated that plasma essential trace elements Se, Cu, and Fe change, but these
changes might be dependent on acute-phase proteins, which were regulated as a part of defense strategies of the organism,
induced by hormonelike substances. 相似文献
9.
Mahomed K Williams MA Woelk GB Mudzamiri S Madzime S King IB Bankson DD 《Biological trace element research》2000,75(1-3):107-118
Preeclampsia is an important cause of maternal and perinatal mortality worldwide. The etiology of this relatively common medical
complication of pregnancy, however, remains unknown. We studied the relationship between maternal leukocyte selenium, zinc,
and copper concentrations and the risk of preeclampsia in a large hospital-based case-control study. One hundred seventy-one
women with proteinuric pregnancy-induced hypertension (with or without seizures) comprised the case group. Controls were 184
normotensive pregnant women. Leukocytes were separated from blood samples collected during the patients’ postpartum labor
and delivery admission. Leukocyte concentrations for the three cations were measured by inductively coupled plasma-mass spectrometry
(ICP-MS). Concentrations for each cation were reported as micrograms per gram of total protein. Women with preeclampsia had
significantly higher median leukocyte selenium concentrations than normotensive controls (3.23 vs 2.80 μg/g total protein,
p<0.0001). Median leukocyte zinc concentrations were 31% higher in preeclamptics as compared with controls (179.15 vs 136.44
μg/g total protein, p<0.0001). Although median leukocyte copper concentrations were slightly higher for cases than controls, this difference did
not reach statistical significance (17.72 vs 17.00 μg/g total protein, p=0.468). There was evidence of a linear increase in risk of preeclampsia with increasing concentrations of selenium and zinc.
The relative risk for preeclampsia was 3.38 (adjusted odds ratio [OR]=3.38, 95% confidence interval [CI]=1.53–7.54) among
women in the highest quartile of the control selenium distribution compared with women in the lowest quartile. The corresponding
relative risk and 95% CI for preeclampsia was 5.30 (2.45–11.44) for women in the highest quartile of the control zinc distribution
compared with women in the lowest quartile. There was no clear pattern of a linear trend in risk with increasing concentration
of leukocyte copper concentrations (adjusted for linear trend in risk =0.299). Our results are consistent with some previous
reports. Prospective studies are needed to determine whether observed alterations in selenium and zinc concentrations precede
preeclampsia or whether the differences may be attributed to preeclampsia-related alterations in maternal and fetal-placental
trace metal metabolism. 相似文献
10.
A. M. Rofe J. C. Philcox D. R. Haynes M. W. Whitehouse P. Coyle 《Biological trace element research》1992,34(3):237-248
The early changes in hepatic metallothionein (MT) and plasma zinc (Zn), copper (Cu), and iron (Fe) were investigated during
the induction of adjuvant (AJ) arthritis in rats in conjunction with cyclosporin (CSA) treatment. Plasma Zn decreased after
AJ injection (60% of control values at 8 h), and this was associated with a 4.5-fold increase in hepatic MT at 8 h. Plasma
Zn was lowest at 16 h (40% of control), whereas hepatic MT concentrations increased to a maximum of 20-fold at 16 h. Changes
in plasma Fe paralleled those of Zn, whereas plasma Cu levels were increased. Plasma metal and hepatic MT concentrations returned
toward normal from d 1–7. At d 14, when marked paw swelling was apparent, hepatic MT and plasma Cu were again increased and
plasma Zn decreased.
Administration of CsA decreased MT induction in rats injected with AJ and also caused a marked recovery in plasma Zn and Fe
levels. These changes were small but significant even in the early stages (up to 24 h) after AJ injection and were followed
by a sustained improvement in all parameters, corresponding to the nonappearance of clinical arthropathy in CsA-treated rats.
TNF-α and IL-6 production by peritoneal macrophages isolated from AJ-injected rats was significantly decreased by CsA treatment
at d 7 and 14. The inhibition of hepatic MT induction during acute and chronic inflammation by cyclosporin emphasizes the
role of the immune system in altered metal homeostasis in inflammation. 相似文献
11.
Ciftci TU Ciftci B Yis O Guney Y Bilgihan A Ogretensoy M 《Biological trace element research》2003,95(1):65-71
The effectiveness and success of antituberculosis therapy is mainly measured by its ability to identify the organism in the
sputum. In certain cases, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness
of antituberculosis therapy. Copper (Cu), zinc (Zn), and selenium (Se) are the essential elements that play a crucial role
in the immune system. The serum levels of these elements vary in many diseases including tuberculosis. In this study, we investigate
whether the serum levels of Cu, Zn, and Se change during antituberculosis therapy. We have included 22 pulmonary tuberculosis
cases that were newly diagnosed with positive sputum and 18 healthy subjects. At the beginning and 2 mo after therapy, serum
levels of Cu, Zn, and Se were measured by atomic absorption spectrometry. Despite Se and Cu levels not being affected during
the treatment, we found that there was a significant increase in the levels of Zn and a decrease in the Cu/Zn ratio. Serum
Zn levels and the Cu/Zn ratio could be used as a valuable laboratory tool for the clinicians to assess response to therapy
or effectiveness of the ongoing antituberculosis therapy. 相似文献
12.
Canatan H Bakan I Akbulut M Halifeoglu I Cikim G Baydas G Kilic N 《Biological trace element research》2004,100(2):117-123
Obesity is among the main contributing factors in the etiology of essential hypertension (EHT). Leptin, the product of the
ob gene, is expressed mainly in adipose tissue. We examined the relationship between two trace elements, zinc (Zn) and copper
(Cu), and leptin in patients with EHT (n=35) and normotensive (NT) controls (n=50) because leptin as well as Zn and Cu were reported to be associated with the pathophysiology of EHT. Plasma leptin levels
were determined with a commercial enzyme-linked immunosorbent assay (ELISA) kit. Atomic absorption spectrophotometry was utilized
to determine plasma Zn and Cu levels. There was a negative correlation between leptin and Zn, and the Zn/Cu ratio (r=−0.359, p<0.05; r=0.361, p<0.05, respectively) in pooled subjects. When subjects were divided based on the presence or absence of hypertension, there
was a negative correlation between leptin and Zn (r=−0.375, p<0.05) as well as leptin and Zn/Cu ratio (r=−0.398, p<0.05) in NT subjects. Similar trends were observed when leptin/BMI (body mass index) levels were utilized. There was no significant
correlations between levels of Cu and leptin or leptin/BMI. In conclusion, in addition to high leptin levels, Zn and the Zn/Cu
ratio were lower in patients with EHT compared to NT controls. 相似文献
13.
To clarify the changes of mineral levels in different tissues of riboflavin-deficient rats, Wistar rats were separated into
three groups. One group was fed a diet ad libitum that was deficient in riboflavin. The other two were fed either the complete
diet that was weight-matched to the riboflavin-deficient group or fed a complete diet ad libitum. In riboflavin-deficient
rats, the hemoglobin concentration and riboflavin contents of blood, liver, and kidney were significantly decreased, compared
with weight-matched and ad libitum-fed controls. The mineral concentrations of tissues are summarized as follows: The iron
(Fe) concentration in the heart, liver, and spleen was decreased in the riboflavin-deficient group compared with the other
groups. Calcium (Ca) and magnesium (Mg) concentrations in tibia were decreased in the riboflavin-deficient group compared
with the other two groups. Copper (Cu) concentration was increased in the heart and liver when the riboflavin-deficient group
was compared with the other groups. Zinc (Zn) concentration was increased in tibia when the riboflavin-deficient group was
compared with the other groups. 相似文献
14.
对单性结实的龟井温州蜜柑和自花授粉结实的鄂柑1号柑橘果实的铁、锰、锌和铜含量的年周期变化进行了测定。结果表明:(1)龟井子房的锌和铜含量在花前至花期居较高,花后趋下降,而鄂柑1号对应值在花期出现明显下降并居较低,花后却有一明显上升;两品种子房(幼果)的铁和锰含量变化却无明显差异,花后呈类似的下降趋势。(2)幼果阶段的果实铁、锰、锌和铜含量均居较高,在果实膨大初期(干旱期)均出现一明显下降,而在果实膨大中期却出现显著上升,之后又趋下降。本文还对果实发育中的微量元素含量动态及其与果实发育之间的关系进行了讨论。 相似文献
15.
Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases 总被引:12,自引:0,他引:12
Viral hepatic diseases, especially those induced by the hepatitis B virus, can progress into more serious pathological outcomes
and eventually to hepatocellular carcinoma. A growing body of evidence indicates that many trace elements play important roles
in a number of carcinogenic processes that proceed through various mechanisms. To examine the status of trace elements during
the development of hepatic carcinoma, we determined the selenium, iron, copper, and zinc levels and copper-to-zinc ratios
in the serum of patients at different stages of viral hepatic disease. We observed significant changes in the selenium, iron
copper, and zinc levels in the serum of patients having hepatocellular carcinoma, relative to those of healthy controls (p<0.05). The mean serum copper level in patients with hepatocellular carcinoma was significantly higher than that of the control
group. In contrast, the mean selenium, iron, and zinc levels in patients having hepatocellular carcinoma were significantly
lower than those of the control group. In addition, the mean zinc level in the serum of patients with hepatic cirrhosis was
significantly lower than that of the control group (p<0.05). Moreover, we found markedly elevated Cu: Zn ratios (p<0.05) in patients having hepatic cirrhosis or hepatocellular carcinoma. Our findings imply that the levels of some trace
elements, such as selenium, iron, copper, and zinc, and Cu:Zn ratios, might serve as biomarkers for the increased severity
of viral hepatic damage. 相似文献
16.
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter 总被引:1,自引:0,他引:1
Metin Ozata Murat Salk Ahmet Aydin Savas Sayin Cagatay Oktenli Zeynel Beyham Askin Isimer I. Caglayan Ozdemir 《Biological trace element research》1999,69(3):211-216
Although endemic goiter has been shown to have a high prevalence in Turkey, little is known about the concentration of urinary
iodine, plasma selenium (Se), copper (Cu), and zinc (Zn) in these patients. We studied on 140 male patient with endemic goiter
(mean age: 22.2 ± 0.19 yr) and 140 healthy male subjects (mean age: 21.8 ± 0.28 yr). Daily urinary iodine excretion was determined
by the ionometric method. Plasma Se, Zn, and Cu were determined by using atomic absorption spectrometry. Daily urinary iodine
excretion was found to be significantly lower in the patient group (38.7 ± 2.26 μg/d) than that of controls (50.73 ± 2.56
μg/day,p = 0.001). Plasma Zn concentrations were also found to be significantly lower in the patient group (1.04 ± 0.03 μg/mL) than
that of controls (1.16 ± 0.02 μg/mL,p = 0.001). No significant difference was determined in Se and Cu concentrations between the patient and control groups. Our
study shows that a moderate iodine deficiency exists in both patients with endemic goiter and control subjects, which indicates
the important role of iodine deficiency in the etiopathogenesis of endemic goiter in Turkey. Zinc deficiency may also contribute
to the pathogenesis of endemic goiter. However, Se and Cu do not seem to have any role in the etiopathogenesis of endemic
goiter in Turkey. A community-based iodine fortification program throughout the country may be proposed to take over the problem,
which also can prevent the contributing effects of other element deficiencies that occur when iodine deficiency is the prevailing
factor. 相似文献
17.
Sodium selenate has been supplemented to all agricultural fertilizers used in Finland since 1984. We followed the changes in selenium, cadmium, zinc and copper content in Finnish human milk between the years 1987 and 1993-1995. A total of 257 milk samples was collected, four weeks after delivery, in two areas: In Helsinki, an urban area, and in Kuopio, a rural area, where elevated copper concentrations have been found in the bedrock. Direct atomic absorption spectrophotometric methods without digestion were used for the analyses. The dependence of trace element content on study time, living area, smoking habits, fish eating frequency, and parity of mothers was studied by analysis of covariance. Inter-element correlations and correlations with mothers' age and fat content in milk were studied by partial correlation. Significant increases were observed in mean selenium (16.4 microg/l and 18.9 microg/l, p < 0.001) and in fat contents (3.4% and 4.0%, p < 0.001), whereas significant decreases were seen in mean zinc (3.00 mg/l and 1.47 mg/l, p < 0.001), copper (0.52 mg/l and 0.43 mg/l, p < 0.001) and cadmium contents (0.095 microg/l and 0.062 microg/l, p < 0.01). In 1987, zinc had a positive correlation with copper and fat. Copper correlated inversely with the mothers' age. In 1993-1995, selenium correlated positively with copper, and zinc correlated inversely with mothers' age. Mothers living area had an effect on copper content in milk. Our results confirm that selenium supplementation to fertilizers in Finland has increased the selenium level in human maternal milk and most likely it also has an effect on the zinc and copper concentrations in maternal milk. 相似文献
18.
Kucukatay V Turgut S Kocamaz E Emmungil G Bor-Kucukatay M Turgut G Akca H Bagci H 《Biological trace element research》2006,114(1-3):185-195
Sulfite is a potentially toxic molecule that might enter the body via ingestion, inhalation, or injection. For cellular detoxification,
mammalians rely on sulfite oxidase to convert sulfite to sulfate. The purpose of this research was to determine the effect
of sulfite on zinc, iron, and copper levels in rat liver and kidney tissues. Forty normal and sulfite oxidase-deficient male
albino rats were divided into four groups that included untreated controls (group C), a sulfite-supplemented group that received
70 mg sodium metabisulfite per kilogram per day (group S), a sulfite oxidase-deficient group (group D), and a sulfite oxidase-deficient
group that was also given 70 mg sodium metabisulfite per kilogram per day (group DS). The iron and zinc levels in the liver
and kidney in groups S and DS were not affected by sulfite treatment compared to their respective controls (groups C and D).
Sulfite exposure led to an increase of kidney copper content in the S group when compared to untreated controls. The kidney
copper levels were significantly increased in the unexposed deficient rats, but it was not different than that of the deficient
rats that were given oral sulfite treatment. These results suggest that kidney copper levels might be affected by exogenous
or endogenous sulfite.
An erratum to this article is available at . 相似文献
19.
Pituitary dwarfism (hGHD) is known to be associated with trace element deficiency, which causes improper functioning of the
involved endocrine system. Previously, we reported on the head hair concentrations of zinc, copper, manganese, and iron from
a total of 418 normal subjects (154 male and 264 female). In this report, we analyzed the head hair concentrations of the
same four trace metals of 103 hGHD children (60 male and 43 female) under treatment with human growth hormone (hGH). These
subjects ranged in age from 5 to 18 yr. The results were compared with 338 agematched normal subjects (120 male and 218 female).
Both male and female hGHD showed approx 1.7 times higher zinc concentrations than normal subjects. Cheruvanky et al. reported
a similar trend but with a slightly lower difference between hGHD and normal subjects.
The average copper content in the hair of both male and female subjects also showed higher values for the hGHD than for the
normal subjects, a trend similar to the values reported by Teraoka et al. In the case of manganese, the concentrations in
hair of the hGHD were approx 50% of the values in the normal subjects. Head hair concentrations of iron in the hGHD were commensurate
with the normal subjects.
Because the content of trace elements in hair varies with the age of subjects, as a control, we investigated the head hair
concentration of zinc from 20 healthy girls ranging in age from 10 to 18 yr. The average zinc concentration decreased from
10 to 12 yr, but no clear relation to age was observed from 13 yr and older. These trends were similar to our previous report.
The zinc concentration in hair and body weight gain over a year was negatively correlated.
The age variation in the content of zinc, copper, manganese, and iron in hair was measured comparing hGHD with the normal
subjects in various ages. Concerning the zinc-level variation of hGHD and normal subjects, there were conspicuous differences
between hGHD and normal subjects. For copper, the variations in concentration with age were similar to zinc. Regarding the
age variations for manganese, hGHD had lower concentrations in hair compared to the normal subjects throughout adolescence
(11–18 yr).
We have studied the effects between the hair and these trace element concentrations in hGHD before and after hGH administration.
These results suggest that hGH affects the metabolism of these trace elements. 相似文献
20.
Milde D Novák O Stu ka V Vyslou il K Machá ek J 《Biological trace element research》2001,79(2):107-114
This article describes a study in which four trace elements (Se, Mn, Cu, and Fe) were analyzed in the blood serum of the patients
with colorectal cancer from the Moravian region of the Czech Republic. Atomic absorption spectrometry with graphite furnace
atomization was used for analysis of selenium and manganese and with flame atomization for analysis of copper and iron. The
observed serum concentrations in adenocarcinoma colorectal patients of selenium were significantly lower (41.8 ± 11.6 μg/L)
and those of manganese (16.3 ± 4.5 μg/L) and iron (2.89 ± 1.23 mg/L) were significantly higher as compared to the age-matched
control group. Copper serum content (0.95 ± 0.28 mg/L) did not significantly differ as compared to healthy population. 相似文献