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Beata Sas-Korczyńska Anna Śladowska Bożena Rozwadowska-Bogusz Sonia Dyczek Jan Lesiak Anna Kokoszka Stanisław Korzeniowski 《Reports of Practical Oncology and Radiotherapy》2010,15(4):79-86
Background
The most often found complications in patients with breast cancer who received radiotherapy are cardiac and pulmonary function disorders and development of second malignancies.Aim
To compare the intensity modulated radiotherapy with the 3D tangential beams technique in respect of dose distribution in target volume and critical organs they generate in patients with early-stage breast cancer who received breast-conserving therapy.Materials and methods
A dosimetric analysis was performed to assess the three radiotherapy techniques used in each of 10 consecutive patients with early-stage breast cancer treated with breast-conserving therapy. Radiotherapy was planned with the use of all the three techniques: 3D tangential beams with electron boost, IMRT with electron boost, and intensity modulated radiotherapy with simultaneous integrated boost.Results
The use of the IMRT techniques enables more homogenous dose distribution in target volume. The range of mean and median dose to the heart and lung was lower with the IMRT techniques in comparison to the 3D tangential beams technique. The range of mean dose to the heart amounted to 0.3–3.5 Gy for the IMRT techniques and 0.4–4.3 for the tangential beams technique. The median dose to the lung on the irradiated side amounted to 4.9–5 Gy for the IMRT techniques and 5.6 Gy for the 3D tangential beams technique.Conclusion
The application of the IMRT techniques in radiotherapy patients with early-stage breast cancer allows to obtain more homogenous dose distribution in target volume, while permitting to reduce the dose to critical organs. 相似文献3.
Claudio De Lazzari 《Computer methods in biomechanics and biomedical engineering》2013,16(12):1359-1368
Mathematical modelling of the cardiovascular system (CVS) can help in understanding the complex interactions between both the ventricles and the septum. By describing the behaviour of the left (right) ventricular free wall, atria and septum using the variable elastance models, it is possible to reproduce their interactions. By relating the mechanical properties of both atria and both ventricles to the electrocardiogram (ECG) signal, it is possible to analyse the effects produced by different ECG delay on haemodynamic parameters. In the cardiovascular field, the incorrect interactions between septum and both ventricular free walls are based on many pathological conditions, i.e. symptomatic heart failure resulting from systolic dysfunction, ischemic dilated cardiomyopathy, and so on. The possible corrections that can be induced on the QRS complex duration in the ECG signal (i.e. cardiac resynchronisation therapy, CRT) can produce benefits improving the clinical status of the patient. The aim of this work was to evaluate, using our numerical simulator of the CVS, the effects induced on coronary blood flow (CBF) and aortic pressure using different ECG times, intra-ventricular and inter-ventricular delays. The results were obtained by reproducing the circulatory baseline and CRT conditions of seven patients described in literature. Haemodynamic simulated results are in accordance with literature data. Also the controversial results on CBF, in presence of CRT, are consistent with those described in the literature. 相似文献
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Hande Bas Ayata Metin Güden Cemile Ceylan Nadir Kücük Kayihan Engin 《Reports of Practical Oncology and Radiotherapy》2011,16(3):95-102