Experimental studies in human tooth wear. II

Studies of human tooth wear have been carried on for the past two years using a machine designed to approximate human chewing motions. During this time wear patterns that resemble those frequently found on the teeth of various American Indian skulls have been produced on casts of the definition. Noticeably among these patterns produced are examples of wear on the front end of the dental arches that result in an edge to edge bite. This type of wear was produced by wearing down casts of a modern dentition with a “normal” overbite. The forces applied to the casts mounted on the machine are variable over a wide range and numerous force combinations are possible. By noting these forces and the resulting vectors, the motions necessary to produce different wear patterns can be determined. This has especially aided in understanding the ways in which the oblique molar wear is produced.     

Inhibition phenomena mechanisms in experimental obeliscoidosis in rabbits. II. Local and systemic antibody responses

A series of experiments was carried out using adult outbred Polish race rabbits of both sexes infected, during spring or autumn, with 10,000 larvae of Obeliscoides cuniculi, either fresh or stored at 4 degrees C. Extracts of mucosal proteins and bile were collected at postmortem 6 or 12 weeks after infection. Antibody levels were determined in antisera, bile and stomach mucosa by haemagglutination and precipitation tests. Local antibody responses were demonstrated in the stomach and bile, and reactions were obtained with the tissue fluids by haemagglutination and precipitation tests with worm antigens and ES products. Additionally, some specific immunological response was observed in the circulation during the primary infection. These results suggest a clear-cut relationship between increased levels of these antibodies and either larval inhibition or worm expulsion during O. cuniculi infections.     

Biotherapeutic effects of Bifidobacterium spp. on orogastric and systemic candidiasis in immunodeficient mice

Two commercially available Bifidobacterium spp. (Bifidobacterium infantis and Bifidobacterium lactis) were compared for their capacities to protect immunodeficient bg/bg-nu/nuand bg/bg-nu/+mice from orogastric and lethal candidiasis. Both Bifidobacterium spp. prolonged the survival of Candida albicans-colonized adult and neonatal bg/bg-nu/numice. The bifidobacteria affected the production of antibodies to C. albicans, inhibited disseminated candidiasis, suppressed weight loss associated with C. albicans infection, inhibited the growth of C. albicans in the alimentary tract, inhibited systemic candidiasis of endogenous origin, and decreased the severity of gastric candidiasis in both mouse strains. B. infantis inhibited systemic candidiasis of endogenous origin better than B. lactis; however, B. lactis was significantly more effective at inhibiting C. albicans colonization of the alimentary tract, suppressing gastric candidiasis, and protecting bg/bg-nu/numice from lethal candidiasis than B. infantis. These results show that Bifidobacterium spp. can protect immunodeficient mice from candidiasis but different species manifest quantitative and qualitative differences in their probiotic and biotherapeutic effects.