Disruption of DNA polymerase ζ engages an innate immune response

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Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

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Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

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Plasticity of the adult human small intestinal stoma microbiota

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Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma

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Prolonged mitosis causes separase deregulation and chromosome nondisjunction

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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops

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RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1

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Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

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Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation

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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

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Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M

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S1-END-seq reveals DNA secondary structures in human cells

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RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination

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Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers

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Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

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Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathway

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Dissecting the treatment-naive ecosystem of human melanoma brain metastasis

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RADX prevents genome instability by confining replication fork reversal to stalled forks

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