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The global rise in the use of methamphetamine has been documented to have reached epidemic proportions. Researchers have focussed on the social implications of the epidemic. A typical drug use cycle consists of concealed drugs use after initiation, addiction, treatment-recovery-relapse cycle, whose dynamics are not well understood. The model by White and Comiskey [41], on heroin epidemics, treatment and ODE modelling, is modified to model the dynamics of methamphetamine use in a South African province. The analysis of the model is presented in terms of the methamphetamine epidemic threshold R0. It is shown that the model has multiple equilibria and using the center manifold theory, the model exhibits the phenomenon of backward bifurcation where a stable drug free equilibrium co-exists with a stable drug persistent equilibrium for a certain defined range of R0. The stabilities of the model equilibria are ascertained and persistence conditions established. Furthermore, numerical simulations are performed; these include fitting the model to the available data on the number of patients with methamphetamine problems. The implications of the results to drug policy, treatment and prevention are discussed. 相似文献
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Historical records of childhood disease incidence reveal complex dynamics. For measles, a simple model has indicated that epidemic patterns represent attractors of a nonlinear dynamic system and that transitions between different attractors are driven by slow changes in birth rates and vaccination levels. The same analysis can explain the main features of chickenpox dynamics, but fails for rubella and whooping cough. We show that an additional (perturbative) analysis of the model, together with knowledge of the population size in question, can account for all the observed incidence patterns by predicting how stochastically sustained transient dynamics should be manifested in these systems. 相似文献
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Contact patterns in populations fundamentally influence the spread of infectious diseases. Current mathematical methods for epidemiological forecasting on networks largely assume that contacts between individuals are fixed, at least for the duration of an outbreak. In reality, contact patterns may be quite fluid, with individuals frequently making and breaking social or sexual relationships. Here, we develop a mathematical approach to predicting disease transmission on dynamic networks in which each individual has a characteristic behaviour (typical contact number), but the identities of their contacts change in time. We show that dynamic contact patterns shape epidemiological dynamics in ways that cannot be adequately captured in static network models or mass-action models. Our new model interpolates smoothly between static network models and mass-action models using a mixing parameter, thereby providing a bridge between disparate classes of epidemiological models. Using epidemiological and sexual contact data from an Atlanta high school, we demonstrate the application of this method for forecasting and controlling sexually transmitted disease outbreaks. 相似文献
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Verdasca J Telo da Gama MM Nunes A Bernardino NR Pacheco JM Gomes MC 《Journal of theoretical biology》2005,233(4):553-561
The effect of spatial correlations on the spread of infectious diseases was investigated using a stochastic susceptible-infective-recovered (SIR) model on complex networks. It was found that in addition to the reduction of the effective transmission rate, through the screening of infectives, spatial correlations have another major effect through the enhancement of stochastic fluctuations, which may become considerably larger than in the homogeneously mixed stochastic model. As a consequence, in finite spatially structured populations significant differences from the solutions of deterministic models are to be expected, since sizes even larger than those found for homogeneously mixed stochastic models are required for the effects of fluctuations to be negligible. Furthermore, time series of the (unforced) model provide patterns of recurrent epidemics with slightly irregular periods and realistic amplitudes, suggesting that stochastic models together with complex networks of contacts may be sufficient to describe the long-term dynamics of some diseases. The spatial effects were analysed quantitatively by modelling measles and pertussis, using a susceptible-exposed-infective-recovered (SEIR) model. Both the period and the spatial coherence of the epidemic peaks of pertussis are well described by the unforced model for realistic values of the parameters. 相似文献
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Autoinfection (within-host inoculum transmission) allows plant pathogens locally to increase their density on an infected host. Estimating autoinfection is of particular importance in understanding epidemic development in host mixtures. More generally, autoinfection influences the rate of host colonization by the pathogen, as well as pathogen evolution. Despite its importance in epidemiological models, autoinfection has not yet been directly quantified. It was measured here on wheat (Triticum aestivum) leaves infected by a pathogenic fungus (Puccinia triticina). Autoinfection was measured either on inoculated leaves or by assessing the local progeny of spontaneous infections, and was described by a model of the form y = microx(alpha), where alpha accounts for host saturation and micro represents the pathogen multiplication rate resulting from autoinfection. It was shown that autoinfection resulted in typical patterns of disease aggregation at the leaf level and influenced lesion distribution in the crop during the first epidemic stages. The parameter micro was calculated by taking overdispersion of the data and density dependence into account. It was found that a single lesion produced between 50 and 200 offspring by autoinfection, within a pathogen generation. By taking into account environmental variability, it was possible to estimate autoinfection under optimal conditions for epidemic development. 相似文献
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Evolution toward multi-year periodicity in epidemics 总被引:1,自引:1,他引:0
We studied why many diseases has multi‐year period in their epidemiological dynamics, whereas a main source of the fluctuation is a seasonality with period of 1 year. Previous studies using a compartment model with seasonality in transmission rate succeed to generate a multi‐year epidemiological dynamics, when, in particular, the seasonal difference is large. However, these studies have focused on the dynamical consequence of seasonal forcing in epidemiological dynamics and an adaptation of pathogens in the seasonal environment has been neglected. In this paper, we describe our study of the evolution of pathogen's sensitivity to seasonality and show that a larger fluctuation in the transmission rate can be favored in the life history evolution of pathogens, suggesting that multi‐year periodicity may evolve by natural selection. Our result proposes a new aspect of the evolution of multi‐year epidemics. 相似文献
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Tuberculosis is a disease of global importance: over 2 million deaths are attributed to this infectious disease each year. Even in areas where tuberculosis is in decline, there are sporadic outbreaks which are often attributed either to increased host susceptibility or increased strain transmissibility and virulence. Using two mathematical models, we explore the role of the contact structure of the population, and find that in declining epidemics, localized outbreaks may occur as a result of contact heterogeneity even in the absence of host or strain variability. We discuss the implications of this finding for tuberculosis control in low incidence settings. 相似文献
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John T. Kemper 《Bulletin of mathematical biology》1981,43(3):249-257
A deterministic model for an SIR epidemic with silent infections is investigated. It is shown for the model studied that the
extent to which silent infections are present may be determined from data concerning only those individuals with symptomatic
infection.
This research was supported by the National Institutes of Health through National Research Service Award GM05839. 相似文献
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James A Pitchford JW Plank MJ 《Proceedings. Biological sciences / The Royal Society》2007,274(1610):741-747
Many recent disease outbreaks (e.g. SARS, foot-and-mouth disease) exhibit superspreading, where relatively few individuals cause a large number of secondary cases. Epidemic models have previously treated this as a demographic phenomenon where each individual has an infectivity allocated at random from some distribution. Here, it is shown that superspreading can also be regarded as being caused by environmental variability, where superspreading events (SSEs) occur as a stochastic consequence of the complex network of interactions made by individuals. This interpretation based on SSEs is compared with data and its efficacy in evaluating epidemic control strategies is discussed. 相似文献
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Moment closure approximations are used to provide analytic approximations to non-linear stochastic population models. They
often provide insights into model behaviour and help validate simulation results. However, existing closure schemes typically
fail in situations where the population distribution is highly skewed or extinctions occur. In this study we address these
problems by introducing novel second-and third-order moment closure approximations which we apply to the stochastic SI and SIS epidemic models. In the case of the SI model, which has a highly skewed distribution of infection, we develop a second-order approximation based on the beta-binomial distribution. In addition, a closure approximation based on mixture distribution is developed in order to capture the behaviour
of the stochastic SIS model around the threshold between persistence and extinction. This mixture approximation comprises a probability distribution
designed to capture the quasi-equilibrium probabilities of the system and a probability mass at 0 which represents the probability
of extinction. Two third-order versions of this mixture approximation are considered in which the log-normal and the beta-binomial are used to model the quasi-equilibrium distribution. Comparison with simulation results shows: (1) the beta-binomial approximation
is flexible in shape and matches the skewness predicted by simulation as shown by the stochastic SI model and (2) mixture approximations are able to predict transient and extinction behaviour as shown by the stochastic SIS model, in marked contrast with existing approaches. We also apply our mixture approximation to approximate a likehood function
and carry out point and interval parameter estimation. 相似文献
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Piero Poletti Bruno Caprile Marco Ajelli Andrea Pugliese Stefano Merler 《Journal of theoretical biology》2009,260(1):31-40
We study how spontaneous reduction in the number of contacts could develop, as a defensive response, during an epidemic and affect the course of infection events. A model is proposed which couples an SIR model with selection of behaviours driven by imitation dynamics. Therefore, infection transmission and population behaviour become dynamical variables that influence each other. In particular, time scales of behavioural changes and epidemic transmission can be different. We provide a full qualitative characterization of the solutions when the dynamics of behavioural changes is either much faster or much slower than that of epidemic transmission. The model accounts for multiple outbreaks occurring within the same epidemic episode. Moreover, the model can explain “asymmetric waves”, i.e., infection waves whose rising and decaying phases differ in slope. Finally, we prove that introduction of behavioural dynamics results in the reduction of the final attack rate. 相似文献
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Baccar R Fournier C Dornbusch T Andrieu B Gouache D Robert C 《Annals of botany》2011,108(6):1179-1194
Background and Aims
The relationship between Septoria tritici, a splash-dispersed disease, and its host is complex because of the interactions between the dynamic plant architecture and the vertical progress of the disease. The aim of this study was to test the capacity of a coupled virtual wheat–Septoria tritici epidemic model (Septo3D) to simulate disease progress on the different leaf layers for contrasted sowing density treatments.Methods
A field experiment was performed with winter wheat ‘Soissons’ grown at three contrasted densities. Plant architecture was characterized to parameterize the wheat model, and disease dynamic was monitored to compare with simulations. Three simulation scenarios, differing in the degree of detail with which plant variability of development was represented, were defined.Key Results
Despite architectural differences between density treatments, few differences were found in disease progress; only the lower-density treatment resulted in a slightly higher rate of lesion development. Model predictions were consistent with field measurements but did not reproduce the higher rate of lesion progress in the low density. The canopy reconstruction scenario in which inter-plant variability was taken into account yielded the best agreement between measured and simulated epidemics. Simulations performed with the canopy represented by a population of the same average plant deviated strongly from the observations.Conclusions
It was possible to compare the predicted and measured epidemics on detailed variables, supporting the hypothesis that the approach is able to provide new insights into the processes and plant traits that contribute to the epidemics. On the other hand, the complex and dynamic responses to sowing density made it difficult to test the model precisely and to disentangle the various aspects involved. This could be overcome by comparing more contrasted and/or simpler canopy architectures such as those resulting from quasi-isogenic lines differing by single architectural traits. 相似文献18.
Long-term spatio-temporal datasets of disease incidences have made it clear that many recurring epidemics, especially childhood infections, tend to synchronize in-phase across suburbs. In some special cases, epidemics between suburbs have been found to oscillate in an out-of-phase ('antiphase') relationship for lengthy periods. Here, we use modelling techniques to help explain the presence of in-phase and antiphase synchronization. The nonlinearity of the epidemic dynamics is often such that the intensity of the outbreak influences the phase of the oscillation thereby introducing 'shear', a factor that is found to be important for generating antiphase synchronization. By contrast, the coupling between suburbs via the immigration of infectives tends to enhance in-phase synchronization. The emerging synchronization depends delicately on these opposite factors. We use theoretical results from continuous time models to provide a framework for understanding the relationship between synchronization patterns for different model structures. 相似文献
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