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There is ample evidence to show that many types of visual information, including emotional information, could be processed in the absence of visual awareness. For example, it has been shown that masked subliminal facial expressions can induce priming and adaptation effects. However, stimulus made invisible in different ways could be processed to different extent and have differential effects. In this study, we adopted a flanker type behavioral method to investigate whether a flanker rendered invisible through Continuous Flash Suppression (CFS) could induce a congruency effect on the discrimination of a visible target. Specifically, during the experiment, participants judged the expression (either happy or fearful) of a visible face in the presence of a nearby invisible face (with happy or fearful expression). Results show that participants were slower and less accurate in discriminating the expression of the visible face when the expression of the invisible flanker face was incongruent. Thus, facial expression information rendered invisible with CFS and presented a different spatial location could enhance or interfere with consciously processed facial expression information. 相似文献
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The idea that memory is not a single mental faculty has a long and interesting history but became a topic of experimental and biologic inquiry only in the mid-20th century. It is now clear that there are different kinds of memory, which are supported by different brain systems. One major distinction can be drawn between working memory and long-term memory. Long-term memory can be separated into declarative (explicit) memory and a collection of nondeclarative (implicit) forms of memory that include habits, skills, priming, and simple forms of conditioning. These memory systems depend variously on the hippocampus and related structures in the parahippocampal gyrus, as well as on the amygdala, the striatum, cerebellum, and the neocortex. This work recounts the discovery of declarative and nondeclarative memory and then describes the nature of declarative memory, working memory, nondeclarative memory, and the relationship between memory systems.The idea that memory is not a single faculty has a long history. In his Principles of Psychology, William James (1890) wrote separate chapters on memory and habit. Bergson (1910) similarly distinguished between a kind of memory that represents our past and memory that is not representational but nevertheless allows the effect of the past to persist into the present. One finds other antecedents as well. McDougall (1923) wrote about explicit and implicit recognition memory, and Tolman (1948) proposed that there is more than one kind of learning. These early proposals were often expressed as a dichotomy involving two forms of memory. The terminologies differed, but the ideas were similar. Thus, Ryle (1949) distinguished between knowing how and knowing that, and Bruner (1969) identified memory without record and memory with record. Later, the artificial intelligence literature introduced a distinction between declarative and procedural knowledge (Winograd 1975). Yet constructs founded in philosophy and psychology are often abstract and have an uncertain connection to biology, that is, to how the brain actually stores information. History shows that as biological information becomes available about structure and function, understanding becomes more concrete and less dependent on terminology. 相似文献
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Marc Alain Züst Patrizio Colella Thomas Peter Reber Patrik Vuilleumier Martinus Hauf Simon Ruch Katharina Henke 《PloS one》2015,10(3)
Recent evidence suggests that humans can form and later retrieve new semantic relations unconsciously by way of hippocampus—the key structure also recruited for conscious relational (episodic) memory. If the hippocampus subserves both conscious and unconscious relational encoding/retrieval, one would expect the hippocampus to be place of unconscious-conscious interactions during memory retrieval. We tested this hypothesis in an fMRI experiment probing the interaction between the unconscious and conscious retrieval of face-associated information. For the establishment of unconscious relational memories, we presented subliminal (masked) combinations of unfamiliar faces and written occupations (“actor” or “politician”). At test, we presented the former subliminal faces, but now supraliminally, as cues for the reactivation of the unconsciously associated occupations. We hypothesized that unconscious reactivation of the associated occupation—actor or politician—would facilitate or inhibit the subsequent conscious retrieval of a celebrity’s occupation, which was also actor or politician. Depending on whether the reactivated unconscious occupation was congruent or incongruent to the celebrity’s occupation, we expected either quicker or delayed conscious retrieval process. Conscious retrieval was quicker in the congruent relative to a neutral baseline condition but not delayed in the incongruent condition. fMRI data collected during subliminal face-occupation encoding confirmed previous evidence that the hippocampus was interacting with neocortical storage sites of semantic knowledge to support relational encoding. fMRI data collected at test revealed that the facilitated conscious retrieval was paralleled by deactivations in the hippocampus and neocortical storage sites of semantic knowledge. We assume that the unconscious reactivation has pre-activated overlapping relational representations in the hippocampus reducing the neural effort for conscious retrieval. This finding supports the notion of synergistic interactions between conscious and unconscious relational memories in a common, cohesive hippocampal-neocortical memory space. 相似文献
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来自多方面的研究表明,面孔的分类和识别位于特定脑区.同时,已有行为实验研究表明,图像的空间高低频特征在面孔分类的不同范畴中起不同的贡献,例如身份更多被低频信号传递,性别被高低频共同传递,而表情更多被高频传递.然而,空间频率在面孔分类中的贡献,其表征和神经机制目前相关研究很少.利用特定癫痫患者植入颅内电极的监控期,呈现不同类型面孔图像,同时记录其颅内脑电,用事件相关电位方法考察了据认为是面孔特定成分的相关电位的潜伏期在170 ms的波形(N170波形)的变化;用电极反应显著性分析考察了空间频率在不同分类特征上的贡献.结果表明,空间高频(HSF)图像的N170潜伏期显著延迟.只呈现空间低频(LSF)图像,N170的潜伏期对普通人面孔会延迟,而对熟悉的名人则没有这个差异.女性面孔诱发的N170在HSF条件下潜伏期明显晚于LSF条件,而男性面孔诱发的波形则不存在这个差异.表情在N170上没有体现出任何差异.但是基于电极的显著性分析表明,有更多的额叶电极参与了表情的加工;身份特征加工有更多电极在空间低频上表现出差异,而性别加工则空间高低频比较平衡.与以往行为结果不同的是,表情加工也有更多低频贡献,而且表情的差异可以在早达114 ms的时候就发生.这符合表情信息在颞枕区域有一个快速基本加工,再传递到其他脑区的认知模型.因此,空间高低频信息在身份和性别上的贡献,可能发生在经典的面孔加工脑区,由N170表达,表情信息不由N170表达,而是在颞枕较广泛的范围内快速加工再传递到别的脑区,如额叶.这是首次利用颅内脑电就空间频率在面孔分类中的贡献的神经机制进行研究,为深入理解脑内面孔各种特征加工的动态过程提供了一个新的切入点. 相似文献
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Aldo Ragazzoni Cornelia Pirulli Domenica Veniero Matteo Feurra Massimo Cincotta Fabio Giovannelli Roberta Chiaramonti Mario Lino Simone Rossi Carlo Miniussi 《PloS one》2013,8(2)
Differential diagnoses between vegetative and minimally conscious states (VS and MCS, respectively) are frequently incorrect. Hence, further research is necessary to improve the diagnostic accuracy at the bedside. The main neuropathological feature of VS is the diffuse damage of cortical and subcortical connections. Starting with this premise, we used electroencephalography (EEG) recordings to evaluate the cortical reactivity and effective connectivity during transcranial magnetic stimulation (TMS) in chronic VS or MCS patients. Moreover, the TMS-EEG data were compared with the results from standard somatosensory-evoked potentials (SEPs) and event-related potentials (ERPs). Thirteen patients with chronic consciousness disorders were examined at their bedsides. A group of healthy volunteers served as the control group. The amplitudes (reactivity) and scalp distributions (connectivity) of the cortical potentials evoked by TMS (TEPs) of the primary motor cortex were measured. Short-latency median nerve SEPs and auditory ERPs were also recorded. Reproducible TEPs were present in all control subjects in both the ipsilateral and the contralateral hemispheres relative to the site of the TMS. The amplitudes of the ipsilateral and contralateral TEPs were reduced in four of the five MCS patients, and the TEPs were bilaterally absent in one MCS patient. Among the VS patients, five did not manifest ipsilateral or contralateral TEPs, and three of the patients exhibited only ipsilateral TEPs with reduced amplitudes. The SEPs were altered in five VS and two MCS patients but did not correlate with the clinical diagnosis. The ERPs were impaired in all patients and did not correlate with the clinical diagnosis. These TEP results suggest that cortical reactivity and connectivity are severely impaired in all VS patients, whereas in most MCS patients, the TEPs are preserved but with abnormal features. Therefore, TEPs may add valuable information to the current clinical and neurophysiological assessment of chronic consciousness disorders. 相似文献
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Event-related potentials (ERP) in response to complex target stimuli, which consisted of a central recognizable picture and a lateral masked image (analyzed at the unconscious level) were recorded in adult subjects and seven-year-old children. ERP components N200, N300, and P400/N400 had different topography and were differently pronounced in adults and children. In adult subjects, the N200 component that reflects the processing of a sensory stimulus was recorded in the temporo-parieto-occipital and occipital areas. In children, N200 was recorded in the caudal regions and the frontal areas of the cortex. Analysis of different waveforms obtained by subtraction of the ERP to the central stimulus from the ERP to the complex stimulus showed that unconscious stimulus processing in adult subjects is not reflected in the ERP structure. In children, an unconsciously processed image incorporated into a complex stimulus evokes processing negativity in the occipital and frontal cortical areas. Comparison of ERP in groups of children divided by their reflectivity/impulsivity showed that, predominantly, the left frontal area is involved in image analysis at the unconscious level in reflective children and, predominantly, the right frontal area participates in unconscious image analysis in impulsive children. It is suggested that the perfection of the visual recognition of a target stimulus, which contains additional unconsciously processed information, consists in growth of the involvement of the left-hemispheric mechanisms (with respective growth of significance of the left-hemispheric mechanisms) and in a decrease in the role of the frontal areas in analysis of sensory information. 相似文献
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Sarah N. Bevins Kerri Pedersen Mark W. Lutman John A. Baroch Brandon S. Schmit Dennis Kohler Thomas Gidlewski Dale L. Nolte Seth R. Swafford Thomas J. DeLiberto 《PloS one》2014,9(8)
Avian influenza is a viral disease that primarily infects wild and domestic birds, but it also can be transmitted to a variety of mammals. In 2006, the United States of America Departments of Agriculture and Interior designed a large-scale, interagency surveillance effort that sought to determine if highly pathogenic avian influenza viruses were present in wild bird populations within the United States of America. This program, combined with the Canadian and Mexican surveillance programs, represented the largest, coordinated wildlife disease surveillance program ever implemented. Here we analyze data from 197,885 samples that were collected from over 200 wild bird species. While the initial motivation for surveillance focused on highly pathogenic avian influenza, the scale of the data provided unprecedented information on the ecology of avian influenza viruses in the United States, avian influenza virus host associations, and avian influenza prevalence in wild birds over time. Ultimately, significant advances in our knowledge of avian influenza will depend on both large-scale surveillance efforts and on focused research studies. 相似文献
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Cerebral Blood Flow and Oxidative Metabolism in Conscious Fischer-344 Rats of Different Ages 总被引:1,自引:1,他引:0
Hidenori Takei Wendy R. Fredericks Edythe D. London Stanley I. Rapoport 《Journal of neurochemistry》1983,40(3):801-805
Abstract: The cerebral metabolic rates for O2 and for glucose were measured in conscious, fasted male Fischer-344 rats at the ages of 3, 12, and 24 months, and cerebral blood flow was determined with 14 C-iodoantipyrine. The metabolic rates for oxygen and glucose were obtained by multiplying blood flow by the O2 and glucose concentration differences, respectively, between blood in the femoral artery and in the superior sagittal sinus. Mean cerebral blood flow and the metabolic rates for oxygen and glucose did not differ significantly (p > 0.05) between 3 and 12 or between 12 and 24 months. Nor did the arteriovenous differences for O2 and for glucose change significantly with age. Because the superior sagittal sinus drains blood mainly from the cerebral cortex, the results indicate that average cerebral cortical oxidative metabolism, and the coupling ratios between the cerebral metabolic rate for oxygen and cerebral blood flow and between the cerebral metabolic rate for glucose and cerebral blood flow, do not change significantly with age in the Fischer-344 rat. 相似文献
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Grant Gillett 《Journal of bioethical inquiry》2011,8(2):145-149
The concept of futility is sometimes regarded as a cloak for medical paternalism in that it rolls together medical and value
judgments. Often, despite attempts to disambiguate the concept, that is true and it can be applied in such a way as to marginalize
the real interests of a patient. I suggest we replace it with a conceptual toolkit that includes physiological futility, substantial benefit (SB), and the risk of unacceptable badness (RUB) in that these concepts allow us to articulate what is at stake in ethical judgments where outcomes are crucial in determining
what should be done. 相似文献
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E. V. Sharova 《Human physiology》2005,31(3):245-254
Analysis of the character and systemic organization of cerebral reactions to external effects aids in adequate evaluation of functional and adaptive human capabilities in norm and pathology. Changes in the spatiotemporal organization of the EEG (according to visual and spectral coherence analyses, as well as localization of equivalent dipole sources of pathological EEG phenomena) and the electrooculogram in response to afferent stimuli at different stages of postcomatose recovery of mental activity were studied in 84 patients with severe brain injury in a prolonged postcomatose unconscious state. Both standard indifferent (a rhythmically flashing light and an acoustic tone) and functionally significant (a moving contrasting black-and-white strip, a red spot, the mother’s voice, music, etc.) afferent stimuli were used. Functionally different reactive changes in the EEG were detected even in deep inhibition of consciousness (a vegetative state). EEG reactions including a strengthening of pathological foci in the CNS with dominant features suggested a poor prognosis. In the absence of such foci, a positive activating effect on mental recovery was found for afferent stimulation, in particular, functionally significant stimulation. Selective sensitivity of the CNS to certain external stimuli was observed for certain unconscious states.__________Translated from Fiziologiya Cheloveka, Vol. 31, No. 3, 2005, pp. 5–15.Original Russian Text Copyright © 2005 by Sharova. 相似文献
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Steve Clarke Tony Elliman Brian Lehaney 《Flexible Services and Manufacturing Journal》2000,12(4):305-320
Business-process reengineering (BPR), like computer information systems development (ISD), deals primarily with process and contains only weak facilities for addressing structure and culture. Manufacturing and ISD have strong roots in the functionalist traditions of natural science, and in a cultural environment their engineering stance deals poorly with obstacles to change. While the structured, or “hard,” engineering approaches have given rise to successful developments, they have not always proved effective. In ISD, the hard engineering methods have a tendency to redefine information systems problems as problems of technical development, and similarly in engineering contexts, BPR risks becoming too focused on technical processes. However, failure to gain commitment and a sense of ownership in new processes is a cause of failure in both BPR and ISD. This article explores a case study where both technical and human issues must be addressed—the extension of student record processing within a university. In this study, the BPR requirement is seen to arise from the users of the information system rather than as an imposed managerial imperative. The use of total systems intervention (TSI) and interactive planning (IP) enabled the immediate technical problems to be separated from underlying BPR requirements and from the need to gain commitment to change. Thus, unnecessary technical effort and the risks of failure from resistance to change were avoided. From the findings of this intervention, it is argued that the wider application of TSI provides a framework within which managerially perceived needs can be translated into a grassroots commitment. 相似文献
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《Journal of receptor and signal transduction research》2013,33(1-4):305-311
AbstractMarmocets were used in a structure activity study of the ability of vaso-pressin analogues to activate plasminogen activator (tPA). In evaluation of dDAVP analogues with L – alanine migrating from position 2 to 9 we found [L – Ala4]dDAVP and [L – Ala5]dDAVP to be potent activators of tPA. Double substitutions in dDAVP showed that combinations of a modification in position 4 valine with a change at position 2 (2 – O – methyltyrosine) generated tPA releasing activity. On the other hand enlargement of the substituent at position 2 (2 – O – ethyltyrosine) completely eliminated the activity of [L – Val4]dDAVP. The tPA activity is dependent on the position of a positively charged group at the amino acid in position 8 of the peptide chain. A shift of the guanido group further away from the backbone (D – arginine to D – homoarginine) resulted in a loss of tPA activating properties. 相似文献
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Oecologia - A recently proposed model of competition was claimed to have predicted accurately the independently estimated densities of four sympatric primates in Kibale Forest, Uganda. The validity... 相似文献