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The polycomb protein Pc2 is a SUMO E3 总被引:37,自引:0,他引:37
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Regulation of the Pro-apoptotic scaffolding protein POSH by Akt 总被引:2,自引:0,他引:2
Lyons TR Thorburn J Ryan PW Thorburn A Anderson SM Kassenbrock CK 《The Journal of biological chemistry》2007,282(30):21987-21997
POSH (Plenty of SH3 domains) binds to activated Rac and promotes apoptosis by acting as a scaffold to assemble a signal transduction pathway leading from Rac to JNK activation. Overexpression of POSH induces apoptosis in a variety of cell types, but apoptosis can be prevented by co-expressing the pro-survival protein kinase Akt. We report here that POSH is a direct substrate for phosphorylation by Akt in vivo and in vitro, and we identify a major site of Akt phosphorylation as serine 304 of POSH, which lies within the Rac-binding domain. We further show that phosphorylation of POSH results in a decreased ability to bind activated Rac, as does phosphomimetic S304D and S304E mutation of POSH. S304D mutant POSH also shows a strongly reduced ability to induce apoptosis. These findings identify a novel mechanism by which Akt promotes cell survival. 相似文献
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Calsenilin interacts with transcriptional co-repressor C-terminal binding protein(s) 总被引:1,自引:0,他引:1
Zaidi NF Kuplast KG Washicosky KJ Kajiwara Y Buxbaum JD Wasco W 《Journal of neurochemistry》2006,98(4):1290-1301
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