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1.
[Pt(COD)Cl2] (COD=1,5-cyclooctadiene) is a versatile starting material for the synthesis of Pt(II) compounds. The preparations of the new compounds [Pt(COD)Cl(NO3)], [Pt(COD)(NO3)2] and [Pt(PPh3)3(NO3)](NO3) and also of the known compounds cis[Pt(PPh3)2Cl2], cis [Pt(PPh3)2Cl(NO3)], cis[Pt(PPh3)2(NO3)2] and [Pt(PPh3)3Cl](NO3)are reported. The compounds are characterized by elemental analysis, 31P{1H} NMR spectroscopy and IR spectroscopy.  相似文献   

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The structures of three Pt(II) thiourea complexes, trans-[(tu)2Pt(NH3)2]Cl2 (1), trans-[(tu)2Pt(CH3NH2)2]Cl2·3H2O (2) and [Pt(tu)4]Cl2 (3), have been determined by X-ray diffraction and refined to R = 0.049 for 1026 reflections (1), R = 0.057 for 2547 reflections (2) and R = 0.046 for 2792 reflections (3). All the compounds crystallize in the space group P21/c and have cell dimensions: a = 5.437(1), b = 6.450(1), c = 17.980(3) Å, β = 96.05(2)°, Z = 2 (compound 1); a = 9.225(1), b = 15.404(2), c = 12.601(2) Å, β = 105.39(2)°, Z = 4 (compound 2); and a = 9.051(6), b = 10.203(6), c = 18.263(8) Å, β = 91.12(8)°, Z = 4 (compound 3). The unit cell of 1 and 3 contains only a single type of cation, while that of 2 is formed from two independent cations. In 1 and 2 the coordination spheres of the Pt atoms are rather similar, with angles close to 90° and coplanarity of the metal and respective donor atoms. Instead, in 3 the four sulfur atoms, which surround the Pt, display a slight distortion (0.06 Å from the mean plane) towards tetrahedral.  相似文献   

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《Carbohydrate research》1988,172(1):11-25
Benzyl-3-O-benzyl-2-benzyloxycarbonylamino-6-O-[2-benzyloxycarbonyl-amino-2-deoxy-3,4-O-(tetraisopropyldisiloxane-1,3-diyl)- β-d-glucopyranosyl]-2-deoxy-α-d-glucopyranoside was coupled with methyl (4,5,7,8-tetra-O-acetyl-3-deoxy-α-d-manno-2-octulopyranosyl bromide)onate (13) to yield the α-glycosidically linked trisaccharide. After deacetylation and selective introduction of a second 7′,8′-O-tetraisopropyldisiloxane group, a further glycosidation reaction with 13 led regioselectively to the tetrasaccharide benzyl O-[methyl (4,5,7,8-tetra-O-acetyl-3-deoxy-α-d-manno-2-octulopyranosyl)onate]-(2→4)-O-{methyl [3-deoxy-7,8-O-(tetraisopropyldisiloxane-1,3-diyl)-α-d-manno-2-octulopyranosyl]-onate}-(2→6)-O- [2-benzyloxycarbonylamino-2-deoxy-3,4-O-(tetraisopropyldisiloxane-1,3-diyl)-β-d-glucopyranosyl]- (1→6)-3-O-benzyl-2-benzyloxycarbonyl-amino-2-deoxy-α-d-glucopyranoside. A series of deblocking steps gave O-(3-deoxy-α-d-manno-2-octulopyranosylonic acid)-(2→4)-O-(3-deoxy-α-d-manno-2-octulopyranosylonic acid)- (2→6)-O-(2-amino-2-deoxy-β-d-glucopyranosyl)-(1→6)-2-amino-2-deoxy-d-glucopyranose which was identical with a tetrasaccharide that had been isolated by hydrazinolysis of the lipopolysaccharide from Salmonella minnesota R 595. Hence, synthetic proof is provided for the linkages in this part of the inner core region of lipopolysaccharides.  相似文献   

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Abstract

2-(3-Deoxy-β-D-erythropentofuranosyl)-thiazole-4-carboxamide was synthesized in four steps from its β-D-ribofuranosyl nucleoside precursor.  相似文献   

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采用正交实验研究了外加Ca~(2+)和La~(3+)对酿酒酵母生长的影响。结果表明:外加Ca~(2+)和La~(3+)对酿酒酵母的生长均有显著的影响,都呈现出低浓度时正效应和高浓度时负效应,当Ca~(2+)浓度为1mmol/L及La~(3+)浓度为15μmol/L时酿酒酵母生长最好。  相似文献   

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Abstract

Reaction of 1-[2,5(and 3,5)-di-O-trityl-β-D-erythro-pentofuran-3 (and 2)-ulosyl]uracil derivatives 5 and 6 with (chloromethyl)triphenylphosphorane resulted in the stereoselective formation of (E)-3′- and (Z)-2′-chloromethylene derivatives 7 (69%) and 8 (53%), respectively, deprotection of which gave 9 and 10. Transformation of the uracil nucleoside 7 into cytosine one followed by deprotection yielded 12. The latter was converted into the arabinoside 14. The fully deprotected chloromethylene nucleosides were tested for their activity against HIV-1 and HIV-2.  相似文献   

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《Inorganica chimica acta》1988,143(2):185-192
Ta2Cl6(SMe2)3 reacts with PhHNNHPh to afford Ta2Cl4(μ-Cl)2(μ-PhN)(PhNH2)3 (1) a compound with a TaIVTaIV single bond, with a length of 2.644(1) Å. The compound crystallizes in space group Pnma with unit cell dimensions a = 22.960(8), b = 16.875(4), c = 6.367(3) Å, V = 2467(1) Å3, and Z = 4. The reaction of Nb2Cl6(SMe2)3 with PhHCNNCHPh, merely on mixing at room temperature produced Nb2Cl6(SMe2) [PhHC(N)PhHCNHNCHPh]·C7H8 (2) as large red crystals in ca. 50% yield. The molecule consists of two NbIV atoms, one six-coordinate and the other seven-coordinate, united by three bridging atoms (Cl, Cl, N) and a NbNb bond of length 2.681(1) Å. The way in which the tridentate triazo ligand is generated is completely obscure. Crystallographic data for 2: space group P21/n with a = 11.393(3), b = 11.988(3), c = 27.233(7) Å, β = 100.75(2)°, V = 3654(3) Å, and Z = 4.  相似文献   

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《Carbohydrate research》1987,161(1):39-47
Condensation of methyl 2,6-di-O-benzyl-β-d-galactopyranoside with 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-d-glucopyrano)-[2,1,-d]-2-oxazoline (1) in 1,2-dichloroethane, in the presence of p-toluenesulfonic acid, afforded a trisaccharide derivative which, on deacetylation, gave methyl 3,4-di-O-(2-acetamido-2-deoxy-β-d-glucopyranosyl)-2,6-di-O-benzyl-β-d- glactopyranoside (5). Hydrogenolysis of the benzyl groups of 5 furnished the title trisaccharide (6). A similar condensation of methyl 2,3-di-O-benzyl-β-d-galactopyranoside with 1 produced a partially-protected disacchraide derivative, which, on O-deacetylation followed by hydrogenolysis, gave methyl 6-O-(2-acetamido-2-deoxy-β-d-glucopyranosyl)-β-d-glactopyranoside (10). Condensation of methyl 3-O-(2-acetamido-4,6-O-benzylidene-2-deoxy-β-d-glucopyranosyl)-2,4,6-tri-O-benzyl-β-d- galactopyranoside with 3-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-d-glucopyranosyl)-2,4,6-tri-O-acetyl-α-d-galactopyranosyl bromide in 1:1 benzene-nitromethane in the presence of powdered mercuric cyanide gave a fully-protected tetrasaccharide derivative, which was O-deacetylated and then subjected to catalytic hydrogenation to furnish methyl O-(2-acetamido-2-deoxy-β-d-glucopyranosyl)-(1→3)-O-β-d-galactopyranosyl-(1å3)-O-(2-acetamido-2-deoxy- β-d-glucopyranosyl)-(1å3)-β-d-galactopyranoside (15). The structures of 6, 10, and 15 were established by 13C-n.m.r. spectroscopy.  相似文献   

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A series of novel 2-aliphatic cyclic amine-3-(arylsulfonyl)quinoxalines was synthesized based on the structural features of a previously identified lead, WR1. The 2-piperidinol-3-(arylsulfonyl)quinoxalines, which showed excellent antitumor activities against five human cell lines, with inhibitory activities ranging from 0.34 to 2.32 μM, proved to be a promising class of novel PI3Kα inhibitors. The most potent compound 10d (WR23) showed an inhibitory IC(50) value of 0.025μM against PI3Kα and significant pAkt suppression effect. Molecular docking analysis was performed to determine possible binding modes between PI3Kα and target compounds.  相似文献   

16.
抗甲3型(H3N2)流行性感冒病毒单克隆抗体的建立   总被引:2,自引:0,他引:2  
将SP2/0 Ag小鼠骨髓瘤细胞与经蔗糖梯度离心纯化的甲3型流感病毒沪防/32/84(H3N2)免疫的BALB/C鼠脾细胞融合,经初步克隆获得了25个能稳定分泌抗甲3型流感病毒单克隆抗体(McAb)的杂交瘤细胞株,部份McAb的一些生物学性状如下。 经ELISA测定25个腹水McAb、除4株为10~(-4)外,其余滴度在10~(-5)~10~(-(?))间。此25个McAb中,16个为抗血凝素McAb,其中15个的血凝抑制效价在1:1,280~1:20,480,1个为1:320,在鸡胚内均有不同  相似文献   

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As a model experiment for the stereoselective synthesis of optically active cis-α,β-dibenzyl-α-hydroxy-γ-butyrolactone, (2R, 3S)-2-benzyl-2-hydroxy-3-(3,4-methylenedioxybenzyl)-γ-butyrolactone (3) was stereoselectively synthesized from L-(+)-arabinose.  相似文献   

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