共查询到20条相似文献,搜索用时 8 毫秒
1.
2.
3.
C. D. Daykin 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》1997,352(1357):1111-1114
Closing remarks to Human genetics - uncertainties and the financial implications ahead. A Discussion held at the Royal Society on 25 and 26 September 1996, and organized and edited by R. M. Anderson. <br> 相似文献
4.
5.
STRAUS WL 《Human biology; an international record of research》1954,26(3):304-312
6.
7.
8.
9.
《Journal of receptor and signal transduction research》2013,33(1-4):609-612
AbstractReceptor phosphorylation is a key step in the process of rapid desensitization. β-Adrenergic receptor kinase is a specific receptor kinase that is known to phosphorylate and induce desensitization of several G-coupled synaptic receptors only when they are occupied by their agonists. We recently cloned human βARK cDNA and reported high levels of βARK expression in human peripheral blood leukocytes, also providing the first evidence for its possible functional role in these cells. Complete homologous receptor desensitization by βARK requires an additional cytosolic factor, called β-arrestin. In the present study, we have cloned a 212 bp fragment of the human β-arrestin cDNA to perform a comparative analysis of βARK and β-arrestin mRNA expression in various human cell types. We found that also β-arrestin mRNA is abundant in non-innervated tissues and cells. The fact that the entire machinery for G-coupled receptor desensitization is highly expressed in these cells further supports the idea that βARK may regulate non-synaptic as well as synaptic receptors. 相似文献
10.
11.
12.
13.
14.
15.
16.
Louis van Liere 《Aquatic Ecology》1986,20(1-2):257-259
17.
18.
19.
20.