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DNA Quality Control by a Lesion Sensor Pocket of the Xeroderma Pigmentosum Group D Helicase Subunit of TFIIH

Nadine Mathieu Nina Kaczmarek Peter Rüthemann Andreas Luch Hanspeter Naegeli 《Current biology : CB》2013,23(3):204-212

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Highlights? Amino acid changes near the central pore of XPD confer defective excision repair ? These mutants retain DNA helicase activity when tested in an archaeal framework ? The mutants are unable to sense lesions during their ATP-driven tracking movement ? The mutants are unable to build a stable demarcation complex at DNA lesion sites 相似文献

The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription,and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency

Luisa Mori Katharine Jenike Yang-Hui Jimmy Yeh Benoît Lacombe Chuan Li Adam J. Getzler Sonia Mediouni Michael E. Cameron Matthew E. Pipkin Ya-Chi Ho Bertha Cecilia Ramirez Susana T. Valente 《Journal of virology》2021,95(4)

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