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1.
The goal of this study was to describe typical motor profiles in younger schoolchildren. A total of 89 subjects aged 8–10
years, students of primary schools of Moscow not going in for sports took part in the study. Twenty-five indices of psychophysiological
(NS-PsihoTest), psychomotor (KID-3), posturography and locomotor tests (nine coordination tests) have been measured. According
to their motor coordination, the children have been subdivided into groups using k-means cluster analysis. The four obtained clusters are supposed to reflect different types of motor coordination and correspond
to four individual motor profiles typical of children aged 8–10 years. These motor coordination types were not associated
with age, sex, or constitution; therefore, they may be promising for selecting sports. The ability to anticipate and a high
speed of wrist movement were typical of children from the first cluster. Subjects from the second cluster were more successful
in rapid, rhythmic, and automatic actions, based on the mechanism of intrinsic programming. Subjects from the third cluster
displayed a moderate ability of postural control, but at the same time, they were characterized by smooth, accurate, and rhythmic
arm actions based on visual feedback, and an advanced sense of rhythm and space sense. Subjects from the fourth cluster were
the most coordinated ones, which is important for sports and occupational activities requiring a high level of coordination. 相似文献
2.
Katrijn Opstoel Johan Pion Marije Elferink-Gemser Esther Hartman Bas Willemse Renaat Philippaerts Chris Visscher Matthieu Lenoir 《PloS one》2015,10(5)
ObjectivesThe aim of this study was to investigate to what extent 9 to 11 year old children participating in a specific sport already exhibit a specific anthropometric, physical fitness and motor coordination profile, in line with the requirements of that particular sport. In addition, the profiles in children with a different training volume were compared and possible differences in training hours per week between children from a low, moderate, and high level of physical fitness and motor coordination were investigated.DiscussionThe study showed that in general, children at a young age do not exhibit sport-specific characteristics, except in children with a high training volume. It is possible that on the one hand, children have not spent enough time yet in their sport to develop sport-specific qualities. On the other hand, it could be possible that they do not take individual qualities into account when choosing a sport. 相似文献
3.
Ebrahim Norouzi Fatemehsadat Hossieni Mehran Solymani 《Applied psychophysiology and biofeedback》2018,43(4):283-292
It is generally accepted that children with attention-deficit/hyperactivity disorder (ADHD) have poor motor control, especially in bimanual coordination tasks. Such children characteristically have impaired fine motor ability, problems with force control, and poor motor coordination. They are at particular risk of loss of motor control and reduced bimanual coordination. We tested whether, compared to a control condition, neurofeedback training (NFT) could improve bimanual coordination among children with ADHD. 20 Children with ADHD (mean age 7.9 years; SD 2.11) were randomly assigned either to NFT or to a control condition. All participants completed a bimanual coordination test at the following time points: baseline, assessment 1, assessment 2, assessment 3, and again 12 session later at posttest. NFT consisted of Sensory Motor Rhythm (SMR) training to achieve increased SMR in C3 and C4, while participants in the control condition were under mock NFT conditions. Bimanual coordination accuracy and consistency improved from baseline to completion of the intervention (significant Time effect), but in the NFT condition (significant time?×?group interaction). Compared to the control condition, the NFT group had fewer errors in both patterns of bimanual coordination (significant Group effect). Among children with ADHD, SMR neurofeedback training (NFT) led to significant improvements in a bimanual coordination task. The SMR NFT thus appears to have the potential to improve and enhance the motor control of ADHD patients. 相似文献
4.
Cook R Johnston A Heyes C 《Proceedings. Biological sciences / The Royal Society》2012,279(1729):669-674
When motion is isolated from form cues and viewed from third-person perspectives, individuals are able to recognize their own whole body movements better than those of friends. Because we rarely see our own bodies in motion from third-person viewpoints, this self-recognition advantage may indicate a contribution to perception from the motor system. Our first experiment provides evidence that recognition of self-produced and friends' motion dissociate, with only the latter showing sensitivity to orientation. Through the use of selectively disrupted avatar motion, our second experiment shows that self-recognition of facial motion is mediated by knowledge of the local temporal characteristics of one's own actions. Specifically, inverted self-recognition was unaffected by disruption of feature configurations and trajectories, but eliminated by temporal distortion. While actors lack third-person visual experience of their actions, they have a lifetime of proprioceptive, somatosensory, vestibular and first-person-visual experience. These sources of contingent feedback may provide actors with knowledge about the temporal properties of their actions, potentially supporting recognition of characteristic rhythmic variation when viewing self-produced motion. In contrast, the ability to recognize the motion signatures of familiar others may be dependent on configural topographic cues. 相似文献
5.
目的:研究3至5岁儿童能否对主动行为、被动行为加以区分以及其控制能力的差异和两者是否相关。方法:设计两个任务:衡量儿童对主动与被动行为区分的意图实验与衡量儿童自我控制能力的七巧板任务。结果:意图实验年龄效应显著,F=48.317,P<0.001。七巧板任务年龄效应显著:F=88.123,P<0.001,意图实验与七巧板任务相关显著:r=0.79 t=8.37,P<0.01。结论:儿童对主动行为和被动行为的区分转折点为4岁;儿童的自我控制能力以坚持性为指标时转折点在4岁;儿童时意图行为的区分与自我控制能力具有相关性。 相似文献
6.
Lazhar Labiadh Marie-Martine Ramanantsoa Eveline Golomer 《Journal of electromyography and kinesiology》2010,20(2):322-329
Imitative behavior underlaid by perception and action links during children’s development in complex locomotor skills has been the object of relatively few studies. In order to explore children’s motor coordination modes, 130 children divided into five age groups from 3.5 to 7.5 years were instructed to imitate jumping tasks in spontaneous motor situation and in various imitative contexts by an adult providing verbal orders and gestural demonstrations. Their conformity to the model, stability and variability scores were coded from a video analysis when they performed jumps with obstacles. To evaluate their postural-motor control level, the durations of the preparatory phase and jumping flights were also timed. Results showed that all age groups generated the demonstrator’s goal but not necessarily the same coordination modes of jumping. In imitation with temporal proximity, the model helped the youngest age groups to adopt his coordination modes and stabilized only the oldest age groups’ performances starting from 5.5 years old, without effect on learning imitation. Differences between the youngest and oldest children in the jump duration suggested that the reproduction of a complex motor activity such as jumping with a one foot take-off would require resolution and adjustment of main postural stability. 相似文献
7.
A spatial scan statistic for multiple clusters 总被引:1,自引:0,他引:1
Spatial scan statistics are commonly used for geographical disease surveillance and cluster detection. While there are multiple clusters coexisting in the study area, they become difficult to detect because of clusters’ shadowing effect to each other. The recently proposed sequential method showed its better power for detecting the second weaker cluster, but did not improve the ability of detecting the first stronger cluster which is more important than the second one. We propose a new extension of the spatial scan statistic which could be used to detect multiple clusters. Through constructing two or more clusters in the alternative hypothesis, our proposed method accounts for other coexisting clusters in the detecting and evaluating process. The performance of the proposed method is compared to the sequential method through an intensive simulation study, in which our proposed method shows better power in terms of both rejecting the null hypothesis and accurately detecting the coexisting clusters. In the real study of hand-foot-mouth disease data in Pingdu city, a true cluster town is successfully detected by our proposed method, which cannot be evaluated to be statistically significant by the standard method due to another cluster’s shadowing effect. 相似文献
8.
Bimanual actions impose intermanual coordination demands not present during unimanual actions. We investigated the functional neuroanatomical correlates of these coordination demands in motor imagery (MI) of everyday actions using functional magnetic resonance imaging (fMRI). For this, 17 participants imagined unimanual actions with the left and right hand as well as bimanual actions while undergoing fMRI. A univariate fMRI analysis showed no reliable cortical activations specific to bimanual MI, indicating that intermanual coordination demands in MI are not associated with increased neural processing. A functional connectivity analysis based on psychophysiological interactions (PPI), however, revealed marked increases in connectivity between parietal and premotor areas within and between hemispheres. We conclude that in MI of everyday actions intermanual coordination demands are primarily met by changes in connectivity between areas and only moderately, if at all, by changes in the amount of neural activity. These results are the first characterization of the neuroanatomical correlates of bimanual coordination demands in MI. Our findings support the assumed equivalence of overt and imagined actions and highlight the differences between uni- and bimanual actions. The findings extent our understanding of the motor system and may aid the development of clinical neurorehabilitation approaches based on mental practice. 相似文献
9.
Kamaldeep K. Gill Jeffy Rajan Soundara Rajan Daniel Goldowitz Jill G. Zwicker 《Genes, Brain & Behavior》2020,19(4)
Motor impairments are a common feature of many neurodevelopmental disorders; in fact, over 50% of children with Attentional Deficit Hyperactivity Disorder or Autism Spectrum Disorder may have a co‐occurring diagnosis of developmental coordination disorder (DCD). DCD is a neurodevelopmental disorder of unknown etiology that affects motor coordination and learning, significantly impacting a child's ability to carry out everyday activities. Animal models play an important role in scientific investigation of behaviour and the mechanisms and processes that are involved in control of motor actions. The purpose of this paper is to present an approach in the mouse directed to gain behavioral and genetic insights into DCD that is designed with high face validity, construct validity and predictive validity. Pre‐clinical and clinical expertise is used to establish a set of scientific criteria that the model will meet in order to investigate the potential underlying causes of DCD. 相似文献
10.
Studies comparing binocular eye movements during reading and visual search in dyslexic children are, at our knowledge, inexistent. In the present study we examined ocular motor characteristics in dyslexic children versus two groups of non dyslexic children with chronological/reading age-matched. Binocular eye movements were recorded by an infrared system (mobileEBT®, e(ye)BRAIN) in twelve dyslexic children (mean age 11 years old) and a group of chronological age-matched (N = 9) and reading age-matched (N = 10) non dyslexic children. Two visual tasks were used: text reading and visual search. Independently of the task, the ocular motor behavior in dyslexic children is similar to those reported in reading age-matched non dyslexic children: many and longer fixations as well as poor quality of binocular coordination during and after the saccades. In contrast, chronological age-matched non dyslexic children showed a small number of fixations and short duration of fixations in reading task with respect to visual search task; furthermore their saccades were well yoked in both tasks. The atypical eye movement''s patterns observed in dyslexic children suggest a deficiency in the visual attentional processing as well as an immaturity of the ocular motor saccade and vergence systems interaction. 相似文献
11.
J.-M. Moulis Valérie Davasse Marie-Pierre Golinelli Jacques Meyer Isabelle Quinkal 《Journal of biological inorganic chemistry》1996,1(1):2-14
Cysteine is the ubiquitous ligand of iron-sulfur clusters in proteins, although chemical models have indicated that functional
groups other than thiolates can coordinate iron in iron-sulfur compounds. Only a small number of naturally occurring examples
of hydroxyl, histidinyl or carboxyl coordination have been clearly established but many others are suspected. Quite a few
site-directed mutagenesis experiments have been aimed at replacing the cysteine ligands of iron-sulfur centers by other amino
acids in various systems. The available data set shows that substituting one ligand, even by another functional residue, is
very often destabilizing enough to impair cluster assembly; in some cases, the apoprotein cannot even be detected. One for
one replacements have been demonstrated, but they have been so far almost exclusively confined to clusters with no more than
one or two iron atoms. In contrast, changes of the cluster nuclearity or recruitment of free cysteine residues seem preferred
ways for proteins containing larger clusters to cope with removal of a ligand, rather than using coordinating amino acids
bearing different chemical functions. Furthermore, the possibility of replacing cysteines by other residues as ligands in
iron-sulfur proteins does not uniquely depend on the ability of the cluster to accept other kinds of coordination than cysteinate;
other factors such as the local flexibility of the polypeptide chain, the accessibility of the solvent and the electronic
distribution on the active centers may also play a prominent role. 相似文献
12.
Sullivan MB Coleman ML Quinlivan V Rosenkrantz JE Defrancesco AS Tan G Fu R Lee JA Waterbury JB Bielawski JP Chisholm SW 《Environmental microbiology》2008,10(10):2810-2823
Oceanic phages are critical components of the global ecosystem, where they play a role in microbial mortality and evolution. Our understanding of phage diversity is greatly limited by the lack of useful genetic diversity measures. Previous studies, focusing on myophages that infect the marine cyanobacterium Synechococcus, have used the coliphage T4 portal-protein-encoding homologue, gene 20 (g20), as a diversity marker. These studies revealed 10 sequence clusters, 9 oceanic and 1 freshwater, where only 3 contained cultured representatives. We sequenced g20 from 38 marine myophages isolated using a diversity of Synechococcus and Prochlorococcus hosts to see if any would fall into the clusters that lacked cultured representatives. On the contrary, all fell into the three clusters that already contained sequences from cultured phages. Further, there was no obvious relationship between host of isolation, or host range, and g20 sequence similarity. We next expanded our analyses to all available g20 sequences (769 sequences), which include PCR amplicons from wild uncultured phages, non-PCR amplified sequences identified in the Global Ocean Survey (GOS) metagenomic database, as well as sequences from cultured phages, to evaluate the relationship between g20 sequence clusters and habitat features from which the phage sequences were isolated. Even in this meta-data set, very few sequences fell into the sequence clusters without cultured representatives, suggesting that the latter are very rare, or sequencing artefacts. In contrast, sequences most similar to the culture-containing clusters, the freshwater cluster and two novel clusters, were more highly represented, with one particular culture-containing cluster representing the dominant g20 genotype in the unamplified GOS sequence data. Finally, while some g20 sequences were non-randomly distributed with respect to habitat, there were always numerous exceptions to general patterns, indicating that phage portal proteins are not good predictors of a phage's host or the habitat in which a particular phage may thrive. 相似文献
13.
Charalampos Mantziaris Till Bockemühl Ansgar Büschges 《Developmental neurobiology》2020,80(1-2):16-30
Central pattern generators (CPGs) are neural circuits that based on their connectivity can generate rhythmic and patterned output in the absence of rhythmic external inputs. This property makes CPGs crucial elements in the generation of many kinds of rhythmic motor behaviors in insects, such as flying, walking, swimming, or crawling. Arguably representing the most diverse group of animals, insects utilize at least one of these types of locomotion during one stage of their ontogenesis. Insects have been extensively used to study the neural basis of rhythmic motor behaviors, and particularly the structure and operation of CPGs involved in locomotion. Here, we review insect locomotion with regard to flying, walking, and crawling, and we discuss the contribution of central pattern generation to these three forms of locomotion. In each case, we compare and contrast the topology and structure of the CPGs, and we point out how these factors are involved in the generation of the respective motor pattern. We focus on the importance of sensory information for establishing a functional motor output and we indicate behavior‐specific adaptations. Furthermore, we report on the mechanisms underlying coordination between different body parts. Last but not least, by reviewing the state‐of‐the‐art knowledge concerning the role of CPGs in insect locomotion, we endeavor to create a common ground, upon which future research in the field of motor control in insects can build. 相似文献
14.
The minimal set of proteins necessary to maintain a vertebrate cell forms an interesting core of cellular machinery. The known proteome of human red blood cell consists of about 1400 proteins. We treated this protein complement of one of the simplest human cells as a model and asked the questions on its function and origins. The proteome was mapped onto phylogenetic profiles, i.e. vectors of species possessing homologues of human proteins. A novel clustering approach was devised, utilising similarity in the phylogenetic spread of homologues as distance measure. The clustering based on phylogenetic profiles yielded several distinct protein classes differing in phylogenetic taxonomic spread, presumed evolutionary history and functional properties. Notably, small clusters of proteins common to vertebrates or Metazoa and other multicellular eukaryotes involve biological functions specific to multicellular organisms, such as apoptosis or cell-cell signaling, respectively. Also, a eukaryote-specific cluster is identified, featuring GTP-ase signalling and ubiquitination. Another cluster, made up of proteins found in most organisms, including bacteria and archaea, involves basic molecular functions such as oxidation-reduction and glycolysis. Approximately one third of erythrocyte proteins do not fall in any of the clusters, reflecting the complexity of protein evolution in comparison to our simple model. Basically, the clustering obtained divides the proteome into old and new parts, the former originating from bacterial ancestors, the latter from inventions within multicellular eukaryotes. Thus, the model human cell proteome appears to be made up of protein sets distinct in their history and biological roles. The current work shows that phylogenetic profiles concept allows protein clustering in a way relevant both to biological function and evolutionary history. 相似文献
15.
Initiation of rapid discrete flexion movements is significantly altered when a secondary rhythmic movement is performed simultaneously
with the same limb; the onset of a stimulus-evoked discrete movement tends to occur time-locked to the oscillation: i.e.,
the rhythmic movement entrains the discrete response. This nonlinear interaction may reflect a specific principle of coordination
of motor tasks which are simultaneously executed with the same effector. This part II of a tripartite research report on such
single-muscle multiple-task coordination investigates the contribution of the dynamic properties of the muscle and its reflex
circuitry to phase entrainment. Assuming a simple threshold-linear relationship between the control signals generated by the
central nervous system and the observable kinematic and electromyographic signals, a secondary rhythmic movement will cause
an additional phase-dependent delay between the central “go” command and the first observable change in actual kinematics
of the compound movement. Several indicators for such threshold-linear interaction are derived and tested on real data obtained
in psychophysical experiments. Four healthy subjects performed rapid lateral abductions of the index finger in response to
a visual “go” signal. During a portion of the experiments, subjects produced additional low-amplitude oscillatory movements
before stimulus presentation with either the same finger (one-handed task), or with the index finger of the other hand (two-handed
task). Results showed phase entrainment and modulation of reaction times when the cyclic and the discrete movements were simultaneously
executed by the same finger. But there was no entrainment in the bimanual execution of the tasks. The model was capable of
reproducing the observed effects. It is concluded that coordination of voluntary movements which are concurrently performed
by the same effector involves specific discontinuous operations, which represents an essential part of the mechanism of motor
coordination. Phase entrainment reflects this characteristic discontinuous behavior of the lower stages of motor execution
and does not necessarily require nonlinear interaction of motor commands at higher levels of motor processing.
Received: 5 September 2001 / Accepted in revised form: 19 December 2001 相似文献
16.
《Anthrozo?s》2013,26(4):393-408
ABSTRACTMany tools assess the reactions of humans encountering familiar or unfamiliar partners or environments. Companion animals belong to our everyday environment and influence our lives. Whereas many standardized tools test companion animals' reactions to humans, few evaluate humans' reactions to companion animals. We present here a test with a guinea pig that can be applied to a wide range of people in the home environment. This standardized test and simple coding system enabled us to characterize individual behavioral profiles of children and compare them in relation to different factors (e.g., gender, age, pet ownership). We observed 59 children (32 girls, 27 boys), aged between 6 and 12 years old. Our results show that most children first looked at the guinea pig (72%), smiled when they saw it (49%), and then went directly towards it without looking at their parent (79%). Many children touched the animal without hesitation (86%). Moreover, this test reveals more than the mere interest of children in guinea pigs. Indeed, a cluster analysis differentiated four behavioral profiles that reflected aspects of the children's experience, gender, and lifestyles. When encountering the unfamiliar guinea pig, children could be “confident” (go straight to the animal and touch it; 64%), “anxious” (look at parent; 12%), “indirect” (hesitate and touch; 14%), or “careful” (emit vocal and/or verbal behaviors; 10%). The potential future application of this research is to compare behavioral profiles quantitatively over the long term, taking into account the development and experiences of people with typical development and those with atypical development (e.g., autistic disorders). 相似文献
17.
Background
Children with Autistic Spectrum Disorders (ASD) are frequently hampered by motor impairment, with difficulties ranging from imitation of actions to recognition of motor intentions. Such a widespread inefficiency of the motor system is likely to interfere on the ontogeny of both motor planning and understanding of the goals of actions, thus delivering its ultimate effects on the emergence of social cognition.Methodology/Principal Findings
We investigate the organization of action representation in 15 high functioning ASD (mean age: 8.11) and in two control samples of typically developing (TD) children: the first one, from a primary school, was matched for chronological age (CA), the second one, from a kindergarten, comprised children of much younger age (CY). We used nine newly designed behavioural motor tasks, aiming at exploring three domains of motor cognition: 1) imitation of actions, 2) production of pantomimes, and 3) comprehension of pantomimes. The findings reveal that ASD children fare significantly worse than the two control samples in each of the inspected components of the motor representation of actions, be it the imitation of gestures, the self-planning of pantomimes, or the (verbal) comprehension of observed pantomimes. In the latter task, owing to its cognitive complexity, ASD children come close to the younger TD children’s level of performance; yet they fare significantly worse with respect to their age-mate controls. Overall, ASD children reveal a profound damage to the mechanisms that control both production and pre-cognitive “comprehension” of the motor representation of actions.Conclusions/Significance
Our findings suggest that many of the social cognitive impairments manifested by ASD individuals are likely rooted in their incapacity to assemble and directly grasp the intrinsic goal-related organization of motor behaviour. Such impairment of motor cognition might be partly due to an early damage of the Mirror Neuron Mechanism (MNM). 相似文献18.
19.
A system is constructed to automatically infer a genetic network byapplication of graphical Gaussian modeling to the expression profiledata. Our system is composed of two parts: one part is automaticdetermination of cluster boundaries of profiles in hierarchicalclustering, and another part is inference of a genetic network byapplication of graphical Gaussian modeling to the clustered profiles.Since thousands of or tens of thousands of gene expression profiles aremeasured under only one hundred conditions, the profiles naturally showsome similar patterns. Therefore, a preprocessing for systematicallyclustering the profiles is prerequisite to infer the relationship betweenthe genes. For this purpose, a method for automatic determination ofcluster boundaries is newly developed without any biological knowledgeand any additional analyses. Then, the profiles for each cluster areanalyzed by graphical Gaussian modeling to infer the relationship betweenthe clusters. Thus, our system automatically provides a graph betweenclusters only by input the profile data. The performance of the presentsystem is validated by 2467 profiles from yeast genes. The clusters andthe genetic network obtained by our system are discussed in terms of thegene function and the known regulatory relationship between genes. 相似文献
20.
Charlotte L. Ridgway Ken K. Ong Tuija H. Tammelin Stephen Sharp Ulf Ekelund Marjo-Riitta Jarvelin 《PloS one》2009,4(8)