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Involvement of nuclear transcription factor Sp1 in regulating glucose transporter-1 gene expression during rat trophoblast differentiation. 总被引:3,自引:0,他引:3
Y Okamoto M Sakata T Yamamoto Y Nishio K Adachi K Ogura M Yamaguchi T Takeda K Tasaka Y Murata 《Biochemical and biophysical research communications》2001,288(4):940-948
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Glucose homeostasis in mammals is achieved by the actions of counterregulatory hormones, namely insulin, glucagon and glucocorticoids.
Glucose levels in the circulation are regulated by the liver, the metabolic centre which produces glucose when it is scarce
in the blood. This process is catalysed by two rate-limiting enzymes, phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase
(G6Pase) whose gene expression is regulated by hormones. Hormone response units (HRUs) present in the two genes integrate
signals from various signalling pathways triggered by hormones. How such domains are arranged in the regulatory region of
these two genes, how this complex regulation is accomplished and the latest advancements in the field are discussed in this
review. 相似文献
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V Kouskoff R M Mantovani S M Candéias A Dorn A Staub B Lisowska-Grospierre C Griscelli C O Benoist D J Mathis 《Journal of immunology (Baltimore, Md. : 1950)》1991,146(9):3197-3204
The X box has been shown in several assay systems to be a critical element of MHC class II gene promoters. Several X box-binding activities have been discovered in nuclear extracts from a variety of cell lines. The critical question is: which of these are responsible for mediating X box function? This report provides a further characterization of NF-X, a highly specific X box-binding activity we described previously. The cell-type distribution, structural features, and binding site characteristics of NF-X are analyzed in detail, to facilitate comparison with other reported activities. Most importantly, the functional relevance of NF-X is assessed by scanning mutagenesis, and the results indicate that this complex is indeed involved in regulating MHC class II gene expression. With these data in mind, the relationship between NF-X and RF-X, an X box-binding activity reported to be absent in patients with severe combined immunodeficiency, is discussed. 相似文献
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