共查询到20条相似文献,搜索用时 109 毫秒
1.
2.
3.
Chatterjee-Kishore M van Den Akker F Stark GR 《The Journal of biological chemistry》2000,275(27):20406-20411
The LMP2 gene, which encodes a protein required for efficient presentation of viral antigens, requires both unphosphorylated Stat1 and IRF1 for basal expression. LMP2 expression is down-regulated by the adenovirus protein E1A, which binds to Stat1 and CBP/p300, and by the mutant E1A protein RG2, which binds to Stat1 but not to CBP/p300, but not by the mutant protein Delta2-36, which does not bind to either Stat1 or CBP/p300. Stat1 and IRF1 associate in untreated cells and bind as a complex to the overlapping ICS-2/GAS element of the LMP2 promoter. E1A interferes with the formation of this complex by occupying domains of Stat1 that bind to IRF1. These results reveal how adenovirus infection attenuates LMP2 expression, thereby interfering with the presentation of viral antigens. 相似文献
4.
Takahashi N Kawada T Yamamoto T Goto T Taimatsu A Aoki N Kawasaki H Taira K Yokoyama KK Kamei Y Fushiki T 《The Journal of biological chemistry》2002,277(19):16906-16912
5.
6.
7.
8.
9.
Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Labalette C Renard CA Neuveut C Buendia MA Wei Y 《Molecular and cellular biology》2004,24(24):10689-10702
10.
11.
12.
Suhara W Yoneyama M Kitabayashi I Fujita T 《The Journal of biological chemistry》2002,277(25):22304-22313
Infections of bacteria and viruses induce host defense reactions known as innate responses including the activation of interferon regulatory factor-3 (IRF-3), critical for the activation of type I interferon system. Upon immediate early signals triggered by the infection, IRF-3 is phosphorylated and a homodimer results. The homodimer complexes with the coactivator CREB-binding protein (CBP)/p300 in the nucleus; thus, holocomplex of IRF-3 competent in DNA binding is generated. We showed CBP/p300 to be indispensable for the DNA binding activity of the holocomplex and to aid the binding through direct interaction with the DNA. We demonstrated that p300 binds with the IRF-3 homodimer via a Q-rich domain and that an intact histone acetyltransferase (HAT) domain is indispensable for the DNA binding of the holocomplex along with a CH3 domain, which connects the HAT and Q-rich domains. These results highlight a novel function of CBP/p300: direct involvement in sequence-specific DNA binding. Furthermore, the critical function of these domains in virus-induced gene activation was demonstrated in vivo by using p300 mutants. 相似文献
13.
14.
15.
16.
17.
18.
19.
20.
Crystal structure of IRF-3 in complex with CBP 总被引:1,自引:0,他引:1
Qin BY Liu C Srinath H Lam SS Correia JJ Derynck R Lin K 《Structure (London, England : 1993)》2005,13(9):1269-1277