共查询到20条相似文献,搜索用时 265 毫秒
1.
???????目的
研究与开发具有皮肤病专科特色的电子病历系统,以实现皮肤科病人医疗信息的采集、加工、存储、传输和服务。方法 以windows sqlserver2005为后台数据库,以XML、C#为开发语言,建立皮肤病结构化病历。结果 该系统运行良好,安全稳定、易维护、通用性好。有效地提高了医生书写病历的速度和质量,并具有皮疹数码照片嵌入等功能。结论 本研究实现了具有皮肤病专科特色的电子病历系统,值得皮肤病医院推荐使用。 相似文献
2.
3.
目的 构建县级综合医院快速绩效评价工具,为改善县医院绩效管理提供依据。方法 应用专题小组法和专家咨询法,筛选关键指标构成快速绩效评价指标体系,采用直接评分法和TOPSIS法计算各医院的绩效综合评价结果。结果 工作质量方面的短板、较低的基本药物配备率和薄弱的人力资源管理是各医院的共性问题。医院费用控制及经济管理维度中的关键政策指标达标率在各医院间波动较大。结论 开发的县级医院快速绩效评价工具具有一定的科学性和可行性。 相似文献
4.
依据标准操作流程模型,将医疗设备管理细分为物流采购控制、应用核算控制和质量技术控制3个方面,实施了医院医疗设备管理的标准化和一些有效的做法, 阐述了加强医疗设备标准化管理的必要性, 提出了建立医疗设备质量管理体系的理念,使医疗设备管理逐步进入质量—效率—效益良性循环的发展轨道。
相似文献5.
通过对国内外床位利用效率评价方法、评价结果的现状分析,总结归纳床位利用效率的影响因素,发现影响床位利用效率的因素主要有国家相关政策、医院自身管理和医护人员行为、病人病种结构及其他不可控因素,国内对床位利用效率的评价研究存在方法单一、影响因素分析不够透彻以及政策建议缺乏针对性和可操作性等几个方面的问题。 相似文献
6.
目的 构建适用于黑龙江省县级医院的绩效评价模型和指标体系,为县级医院开展绩效评价、改善绩效管理提供决策参考。方法 应用文献分析法和专题小组讨论法构建评价模型和初始指标库,运用专家咨询法筛选评价指标并确定指标权重。结果 运用关键绩效指标理念构建了以工作质量、工作效率、医疗费用、综合管理及满意度评价为核心维度的县级医院绩效评价模型及指标体系。结论 指标体系的可信程度较高,能有效反映县级医院绩效管理的核心环节。 相似文献
7.
????? 目的 探索公立医疗机构公益性评价的方法。方法 采用涵盖公平性与可及性、适宜性、质量和效率4个维度的18个指标,应用秩和比法、TOPSIS法和效度系数法对某市10家公立医院的公益性进行分析,用Kendall’s W协同系数检验对3种评价方法的结果的一致性进行检验。结果 3种评价方法都可以用于医疗机构公益性评价,Kendall’s W协同系数检验的结果说明3种评级方法具有很好的一致性。结论 3种方法各有利弊,可以运用多种方法评价公立医疗机构的公益性,数据的可得性成为公立医疗机构机构公益性评价的重要制约因素。
相似文献8.
9.
通过对以往血液透析中心的手工管理模式缺陷的分析,重点介绍Nexadia数据管理系统的基本功能和特点,并积极探索其应用于血液净化中心日常工作所发挥的积极作用。
相似文献10.
11.
12.
13.
Piotr Kuna Yavor Ivanov Vasily Ivanovich Trofimov Takefumi Saito Ola Beckman Thomas Bengtsson Carin Jorup Fran?ois Maltais 《Respiratory research》2013,14(1):64
Background
We investigated the efficacy and safety of AZD3199, a novel inhaled ultra-LABA, with the main aim of establishing a dose that would maintain 24-hour bronchodilation in patients with COPD.Methods
Patients (n = 329) were randomized to AZD3199 (200, 400 or 800 μg o.d.), formoterol (9 μg b.i.d.) or placebo via Turbuhaler® in a parallel group study. The primary objective of the study was to compare the clinical efficacy of three doses of AZD3199 inhaled once daily with 9 μg formoterol twice daily and placebo, over a 4-week treatment period in adults with moderate-to-severe COPD. After 4 weeks, peak (0–4 h) and trough (24–26 h) forced expiratory volume in 1 second (FEV1) were assessed as the primary efficacy outcome variables.Results
All AZD3199 doses significantly increased mean peak and trough FEV1 versus placebo (106–171 ml and 97–110 ml increases, respectively), but with no clear dose–response; the level of bronchodilation was comparable to or greater than that achieved with formoterol. Forced vital capacity (FVC) at peak bronchodilation also significantly increased with AZD3199 versus placebo (153–204 ml). COPD symptom scores and reliever use were reduced with AZD3199, while FEV1 reversibility was unaltered. Adverse events were mild-to-moderate, with no safety concerns identified. Drug exposure was dose-proportional, but lower than predicted from healthy volunteers.Conclusions
All three doses of AZD3199 produced 24-hour bronchodilation, but with no clear dose–response, suggesting that doses of 200 μg or less may be sufficient to maintain bronchodilation over 24 hours in patients with COPD. No safety concerns were identified. Further studies are required to determine the once-daily AZD3199 dose for COPD.Trial registration
Clinicaltrials.gov, NCT00929708相似文献14.
Jasmin B Kuemmerle-Deschner Helmut Wittkowski Pascal N Tyrrell Ina Koetter Peter Lohse Katharina Ummenhofer Fabian Reess Sandra Hansmann Assen Koitschev Christoph Deuter Anja Bialkowski Dirk Foell Susanne M Benseler 《Arthritis research & therapy》2013,15(3):R64
Objectives
Muckle-Wells syndrome (MWS) is an autoinflammatory disease characterized by excessive interleukin-1 (IL-1) release, resulting in recurrent fevers, sensorineural hearing loss, and amyloidosis. IL-1 inhibition with anakinra, an IL-1 receptor antagonist, improves clinical symptoms and inflammatory markers. Subclinical disease activity is commonly observed. Canakinumab, a fully human IgG1 anti-IL-1β monoclonal antibody, can abolish excess IL-1β. The study aim was to analyze the efficacy and safety of these two anti-IL-1 therapies.Methods
Two cohorts of patients with severe MWS and confirmed NLRP3 mutation were treated with anakinra and/or canakinumab. Clinical and laboratory features including ESR, CRP, SAA, and the neutrophil marker S100A12 were determined serially. Disease activity was captured by MWS disease activity scores (MWS-DAS). Remission was defined as MWS-DAS ≤5 plus normal CRP and SAA. Treatment efficacy and safety were analyzed.Results
The study included 12 anakinra- and 14 canakinumab-treated patients; the median age was 33.5 years (3.0 years to 72.0 years); 57% were female patients. Both treatment regimens led to a significant reduction of clinical disease activity and inflammatory markers. At last follow-up, 75% of anakinra-treated and 93% of canakinumab-treated patients achieved remission. During follow-up, S100A12 levels mirrored recurrence of disease activity. Both treatment regimens had favorable safety profiles.Conclusions
IL-1 blockade is an effective and safe treatment in MWS patients. MWS-DAS in combination with MWS inflammatory markers provides an excellent monitoring tool set. Canakinumab led to a sustained control of disease activity even after secondary failure of anakinra therapy. S100A12 may be a sensitive marker to detect subclinical disease activity. 相似文献15.
16.
James F Donohue Dennis Niewoehner Jean Brooks Dianne O’Dell Alison Church 《Respiratory research》2014,15(1):78
Background
The long-acting muscarinic antagonist (LAMA) umeclidinium (UMEC) and the combination of UMEC with the long-acting β2-agonist (LABA) vilanterol (UMEC/VI) are approved maintenance treatments for chronic obstructive pulmonary disease (COPD) in the US and EU. They are not indicated for the treatment of asthma.Methods
In this 52-week, double-blind, placebo-controlled, parallel-group safety study (GSK study DB2113359; ), patients were randomized 2:2:1 to UMEC/VI 125/25 mcg, UMEC 125 mcg, or placebo. Study endpoints included adverse events (AEs), clinical chemistry and hematology parameters, vital signs, 12-lead, and 24-hour Holter electrocardiograms. COPD exacerbations and rescue medication use were assessed as safety parameters; lung function was also evaluated. NCT01316887Results
The incidence of on-treatment AEs, serious AEs (SAEs), and drug-related AEs was similar between treatment groups (AEs: 52–58%; SAEs: 6–7%; drug-related AEs: 12–13%). Headache was the most common AE in each treatment group (8–11%). AEs associated with the LAMA and LABA pharmacologic classes occurred at a low incidence across treatment groups. No clinically meaningful effects on vital signs or laboratory assessments were reported for active treatments versus placebo. The incidences of atrial arrhythmias with UMEC/VI 125/25 mcg were similar to placebo; for UMEC 125 mcg, the incidences of ectopic supraventricular beats, sustained supraventricular tachycardia, and ectopic supraventricular rhythm were ≥2% greater than placebo. With active treatments, COPD exacerbations were fewer (13–15% of patients reporting ≥1 exacerbation) and on average less rescue medication was required (1.6–2.2 puffs/day) versus placebo (24% reporting ≥1 exacerbation, 2.6 puffs/day). Both active treatments improved lung function versus placebo.Conclusion
UMEC/VI 125/25 mcg and UMEC 125 mcg were well tolerated over 12 months in patients with COPD. 相似文献17.
18.
Hamid Galehdari Ali Mohammad Foroughmand Maryam Naderi Soorki Gholamreza Mohammadian 《Indian journal of human genetics》2009,15(1):9-12
BACKGROUND:
The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness. We, therefore, for the first time, investigated the prevalence and frequency of the GJB2 gene mutation in the Iranian deaf population with Arabian origins.MATERIALS AND METHODs:
We amplified and sequenced the entire coding sequence of the GJB2 gene from 61 deaf patients and 26 control subjects.RESULT:
None of the analyzed samples revealed deafness-associated mutation.CONCLUSION:
This finding differs from several reports from Iran as we have focused on the GJB2 gene that possesses various mutations as the cause of congenital recessive deafness. 相似文献19.
Background
Surgical Site Infections (SSI) are relatively frequent complications after colorectal surgery and are associated with substantial morbidity and mortality.Objective
Implementing a bundle of care and measuring the effects on the SSI rate.Design
Prospective quasi experimental cohort study.Methods
A prospective surveillance for SSI after colorectal surgery was performed in the Amphia Hospital, Breda, from January 1, 2008 until January 1, 2012. As part of a National patient safety initiative, a bundle of care consisting of 4 elements covering the surgical process was introduced in 2009. The elements of the bundle were perioperative antibiotic prophylaxis, hair removal before surgery, perioperative normothermia and discipline in the operating room. Bundle compliance was measured every 3 months in a random sample of surgical procedures.Results
Bundle compliance improved significantly from an average of 10% in 2009 to 60% in 2011. 1537 colorectal procedures were performed during the study period and 300 SSI (19.5%) occurred. SSI were associated with a prolonged length of stay (mean additional length of stay 18 days) and a significantly higher 6 months mortality (Adjusted OR: 2.71, 95% confidence interval 1.76–4.18). Logistic regression showed a significant decrease of the SSI rate that paralleled the introduction of the bundle. The adjusted Odds ratio of the SSI rate was 36% lower in 2011 compared to 2008.Conclusion
The implementation of the bundle was associated with improved compliance over time and a 36% reduction of the SSI rate after adjustment for confounders. This makes the bundle an important tool to improve patient safety. 相似文献20.
A. W. den Hartog R. Franken M. P. van den Berg A. H. Zwinderman J. Timmermans A. J. Scholte V. de Waard A. M. Spijkerboer G. Pals B. J. M. Mulder M. Groenink 《Netherlands heart journal》2016,24(11):675-681