Antibody Engineering & Therapeutics 2015: The Antibody Society's annual meeting December 7–10, 2015, San Diego,CA

Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society, will be held in San Diego, CA in early December 2015. In this meeting preview, the chairs provide their thoughts on the importance of their session topics, which include antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, overcoming resistance to clinical immunotherapy, and building comprehensive IGVH-gene repertoires through discovering, confirming and cataloging new germline IGVH genes. The Antibody Society's special session will focus on “Antibodies to watch” in 2016, which are a subset of the nearly 50 antibodies currently in Phase 3 clinical studies. Featuring over 100 speakers in total, the meeting will commence with keynote presentations by Erica Ollmann Saphire (The Scripps Research Institute), Wayne A. Marasco (Dana-Farber Cancer Institute/Harvard Medical School), Joe W. Gray (Oregon Health & Science University), and Anna M. Wu (University of California Los Angeles), and it will conclude with workshops on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries and on computational antibody design.     

Antibody Engineering & Therapeutics 2015: The Antibody Society's annual meeting December 7–10, 2015, San Diego,CA

Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society, will be held in San Diego, CA in early December 2015. In this meeting preview, the chairs provide their thoughts on the importance of their session topics, which include antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, overcoming resistance to clinical immunotherapy, and building comprehensive IGVH-gene repertoires through discovering, confirming and cataloging new germline IGVH genes. The Antibody Society''s special session will focus on “Antibodies to watch” in 2016, which are a subset of the nearly 50 antibodies currently in Phase 3 clinical studies. Featuring over 100 speakers in total, the meeting will commence with keynote presentations by Erica Ollmann Saphire (The Scripps Research Institute), Wayne A. Marasco (Dana-Farber Cancer Institute/Harvard Medical School), Joe W. Gray (Oregon Health & Science University), and Anna M. Wu (University of California Los Angeles), and it will conclude with workshops on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries and on computational antibody design.     

中东以外地区最大一次中东呼吸综合征暴发,韩国,2015

2015年5月11日至12月23日在韩国由一名从中东返回的旅行者引发了中东呼吸综合征暴发。186人发病,38人死亡。年龄偏大和存在基础性疾患是病人死亡的危险因素。这是中东以外地区最大一次中东呼吸综合征暴发,具有以下流行病学特征:(1)医院感染是最重要的暴发原因,但大量受攻击的是非护理人员(154/184);(2)家庭感染少见,无社区感染,传播呈多中心性;(3)呈现多代型继发感染病例,第1代感染者26例,第2代120例,第3代22例,第4代5例;(4)传播方式主要是微滴传播,直接接触传播仅约10%,大多数感染发生于和病人相处同一护理环境,最大可能是污染物传播。此外,中国发现由韩国输入的一例中东呼吸综合征病例。韩国暴发期间的MERS-COV有较高的遗传变异性和突变率。     

专注目标,锐意进取——帝斯曼发布2015战略目标

一场百年未遇的金融危机让全球经济蒙上一层阴影.然而作为始终关注并致力于经济效益、环境质量和社会责任三方面和谐发展的帝斯曼公司在这场鏖战中不负所望,实现了"愿景2010"的绝大部分战略目标,成功转型成为生命科学和材料科学的专业公司.并于2010年底公布了今后五年的新战略--"专注目标,锐意进取".     

Antibody engineering & therapeutics,the annual meeting of the antibody society December 7–10, 2015, San Diego,CA, USA

The 26th Antibody Engineering & Therapeutics meeting, the annual meeting of The Antibody Society united over 800 participants from all over the world in San Diego from 6–10 December 2015. The latest innovations and advances in antibody research and development were discussed, covering a myriad of antibody-related topics by more than 100 speakers, who were carefully selected by The Antibody Society. As a prelude, attendees could join the pre-conference training course focusing, among others, on the engineering and enhancement of antibodies and antibody-like scaffolds, bispecific antibody engineering and adaptation to generate chimeric antigen receptor constructs. The main event covered 4 d of scientific sessions that included antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, building comprehensive IgVH-gene repertoires through discovering, confirming and cataloging new germline IgVH genes, and overcoming resistance to clinical immunotherapy. The Antibody Society's special session focused on “Antibodies to watch” in 2016. Another special session put the spotlight on the limitations of the new definitions for the assignment of antibody international nonproprietary names introduced by the World Health Organization. The convention concluded with workshops on computational antibody design and on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries.     

2015年诺贝尔化学奖

2015年诺贝尔化学奖被授予托马斯·林达尔、保罗·莫德里奇和阿齐兹·桑贾尔,以表彰他们在分子水平上解析出细胞如何修复受损DNA及保护遗传信息。他们的工作为活体细胞是如何工作提供了基础的认知,以及例如,如何用于新癌症疗法的开发。     

2015年中国科技论文统计结果发布会”于2015年10月21日在北京举行

<正>由科技部中国科学技术信息研究所主持的"2015年中国科技论文统计结果发布会"于2015年10月21日在北京国际会议中心举行,会议主要概括了中国科技论文产出的总体趋势;介绍了中国科技论文的学科、地区和部门分布情况;评价了中国科技论文的国际和国内影响;分析了不同学科领域内的机构论文产出情况。科技论文和专利的产出情况是测度科学技术发展水平的重要指标,中国科学技术信息研究所自1987年以来坚持每年向社会公布中国科技论文统计结果。     

Trends in cancer incidence in the Republic of Mauritius, 1991–2015

IntroductionMauritius, a small state, is among the few African countries where cancer registration is population based and nationwide. We reported trends in cancer incidence for twenty five years as well as the mortality to incidence ratio (MIR) as main quality indicator of the Mauritius National Cancer Registry (MNCR).Materials and methodsWe calculated age standardised incidence rates (ASRs) of cancers by sex and by 5 year age group for five successive year periods from 1991 to 2015. The average annual percentage change (AAPC) were determined by sex and cancer sites. MIRs were compared for the period 2001–2004 and 2012–2015.ResultsIn males, the most common cancer sites (in terms of ASRs per 100,000) were those of the colon-rectum (17.0), prostate (16.5), trachea-bronchus-lung (13.0), stomach (8.4) and lip-oral cavity-pharynx (7.7). The AAPC were +3.9%, +4.2%, +0.5%, -0.1% and -1.3% respectively. In females, the most frequent sites were breast (53.7), colon-rectum (13.2), cervix uteri (11.2), corpus uteri (7.7) and ovary (5.7). The AAPC were +3.4%, +4.4%, -2%, +5.2% and -0.1% respectively. The most significant decrease in MIRs among males were liver (1.9 to 1.0), stomach (1.3 to 0.8) and lung (1.7 to 1.2) cancers while among females, they were pancreas (3.4 to 1.3), liver (1.8 to 1.2) and stomach (1.5 to 0.8) cancers.ConclusionThe most common cancers were those associated with 'westernisation' of lifestyle. Our figures contrast with other Sub-Saharan Africa countries where infection related cancers are most predominant. The MNCR has also improved its data quality over time.     

纤细滇美龙(Dianmeisaurus gracilis Shang & Li,2015)新材料

根据一件产自云南罗平中三叠世关岭组Ⅱ段的新标本并结合产自相同地点和地层中的模式标本对纤细滇美龙(Dianmeisaurus gracilis Shang & Li,2015)进行了详细研究.原模式标本暴露其腹而,而新标本暴露其背面,两者互相补充提供了更完整、精确的纤细滇美龙解剖学信息.新材料揭示该种具有非常短小的吻部,眶前区的长度不仅短于眶后区长度,甚至短于眼眶的长度;外鼻孔小且位置靠前,即鼻孔前区的长度短于鼻孔后缘与眼眶前缘之间的距离;由两额骨构成的眼眶间隔非常狭窄,宽度小于顶骨平台宽度的1/3;额骨前后两端均具渐尖的突起;顶骨后部不收缩,顶骨平台后缘呈深V型.补充了新信息和包含更多属种(如Dawazisaurus)后的系统发育学分析支持了之前滇美龙和滇东龙互为姊妹群的结论,同时它们和马家山龙、滇肿龙、贵州龙和大洼子龙一起构成了一个仅由中国的属种组成的单系类群.与欧洲肿肋龙类群(Dactylosaurus,Anarosaurus,Serpianosaurus和Neusticosaurus)相比,这一单系类群与幻龙类有更近的亲缘关系.     

“2015中国遗传学会大会”将在昆明召开

<正>为了推动我国遗传学的发展,交流遗传学领域的新成果、新进展,共同探讨遗传学领域的热点、难点问题,共商合作发展,由中国遗传学会主办,云南大学、云南省科协、云南省遗传学会承办的"2015中国遗传学会大会"将于2015年8月14~18日在昆明云安会都召开,大会主题是"遗传多样性:前沿与挑战"。大会组委会主席:张亚平指导委员会主席:沈岩;学术委员会主席:贺林;工作委员会主席:薛勇彪。大会主要内容:大会报告在主会场进行。大会设置5个专题:(1)人类遗传学与健康;(2)动物遗传学;(3)植物遗传学;(4)微生物遗传学与环境;(5)发育遗传学与表观遗传学。     

中国动物学会2015年活动计划

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2015年武汉生物工程学院论文汇总表

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Metabolism of Some “Second”– and “Fourth”–Generation Antidepressants: Iprindole, Viloxazine, Bupropion, Mianserin, Maprotiline, Trazodone, Nefazodone, and Venlafaxine

1. This review summarizes the major known aspects of the metabolism of second-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants.2. Discussions about specific enzymes involved and about possible pharmacokinetic drug–drug interactions, particularly as they relate to cytochrome P450 enzymes, are provided.     

纤细滇美龙(Dianmeisaurus gracilis Shang & Li,2015)新材料（英文）

根据一件产自云南罗平中三叠世关岭组II段的新标本并结合产自相同地点和地层中的模式标本对纤细滇美龙(Dianmeisaurus gracilis ShangLi,2015)进行了详细研究。原模式标本暴露其腹面,而新标本暴露其背面,两者互相补充提供了更完整、精确的纤细滇美龙解剖学信息。新材料揭示该种具有非常短小的吻部,眶前区的长度不仅短于眶后区长度,甚至短于眼眶的长度;外鼻孔小且位置靠前,即鼻孔前区的长度短于鼻孔后缘与眼眶前缘之间的距离;由两额骨构成的眼眶间隔非常狭窄,宽度小于顶骨平台宽度的1/3;额骨前后两端均具渐尖的突起;顶骨后部不收缩,顶骨平台后缘呈深V型。补充了新信息和包含更多属种(如Dawazisaurus)后的系统发育学分析支持了之前滇美龙和滇东龙互为姊妹群的结论,同时它们和马家山龙、滇肿龙、贵州龙和大洼子龙一起构成了一个仅由中国的属种组成的单系类群。与欧洲肿肋龙类群(Dactylosaurus,Anarosaurus,Serpianosaurus和Neusticosaurus)相比,这一单系类群与幻龙类有更近的亲缘关系。