Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis

Purinergic Signalling - Purinergic signaling is important in the activation and differentiation of macrophages, which play divergent roles in the pathophysiology of liver fibrosis. The...     

The role of purinergic P2Y12 and P2Y13 receptors in ADPβS-induced inhibition of the cardioaccelerator sympathetic drive in pithed rats

Purinergic Signalling - ATP is a cotransmitter released with other neurotransmitters from sympathetic nerves, where it stimulates purinergic receptors. Purinergic adenosine P1 receptors (coupled to...     

Selectivity of the P2X3 receptor antagonist Eliapixant,and its potential use in the treatment of endometriosis

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Announcement of the resignation of Herbert Zimmerman as an Associate Editor

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P2X7R: pivotal player in sepsis-induced liver damage

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Memories of Prof. Geoffrey Burnstock

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Editorial-In tribute to Geoff Burnstock

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Preface to special issue (Commercial Developments in Purinergic Signalling)

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Extracellular levels of the sleep homeostasis mediator,adenosine, are regulated by glutamatergic neurons during wakefulness and sleep

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Purinergic signalling in the gastrointestinal tract and related organs in health and disease

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive intestinal peptide, is a cotransmitter in non-adrenergic, non-cholinergic inhibitory neuromuscular transmission. P2X and P2Y receptors are widely expressed in myenteric and submucous enteric plexuses and participate in sympathetic transmission and neuromodulation involved in enteric reflex activities, as well as influencing gastric and intestinal epithelial secretion and vascular activities. Involvement of purinergic signalling has been identified in a variety of diseases, including inflammatory bowel disease, ischaemia, diabetes and cancer. Purinergic mechanosensory transduction forms the basis of enteric nociception, where ATP released from mucosal epithelial cells by distension activates nociceptive subepithelial primary afferent sensory fibres expressing P2X3 receptors to send messages to the pain centres in the central nervous system via interneurons in the spinal cord. Purinergic signalling is also involved in salivary gland and bile duct secretion.     

Geoffery Burnstock’s influence on the evolution of P2X3 receptor pharmacology

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Journal club

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P2X7 receptors and glioma cells

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Editorial

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From the Sino-German collaboration on purines to the Chinese Purine Club

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Announcement of changes to the editorial board

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Poems to Geoff

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Purines help determine the gut’s sweet tooth

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What strikes most when we think of Geoff

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A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders

Purinergic Signalling -