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Peter J. Houghton 《Phytochemistry》1985,24(4):819-826
A methanolic extract of Buddleja davidii stem yielded the known compounds coniferaldehyde, balanophonin and syringaresinol, and six novel compounds which were characterized as arylglycerol-substituted lignans and neolignans. These have been named buddlenols A-F. 相似文献
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Michael A. Borowitzka 《Journal of applied phycology》1995,7(1):3-15
In the last decade the screening of microalgae, especially the cyanobacteria (blue-green algae), for antibiotics and pharmacologically
active compounds has received ever increasing interest. A large number of antibiotic compounds, many with novel structures,
have been isolated and characterised. Similarly many cyanobacteria have been shown to produce antiviral and antineoplastic
compounds. A range of pharmacological activities have also been observed with extracts of microalgae, however the active principles
are as yet unknown in most cases. Several of the bioactive compounds may find application in human or veterinary medicine
or in agriculture. Others should find application as research tools or as structural models for the development of new drugs.
The microalgae are particularly attractive as natural sources of bioactive molecules since these algae have the potential
to produce these compounds in culture which enables the production of structurally complex molecules which are difficult or
impossible to produce by chemical synthesis. 相似文献
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Hasan Aydin Süleyman Akocak Nebih Lolak Uğur Uslu Ahmet Sait Serol Korkmaz Ayşe Parmaksiz Onur Ceylan Abdulbaki Aksakal 《Journal of biochemical and molecular toxicology》2023,37(10):e23467
Multidrug resistance (MDR) causes difficulties in the treatment of infections and cancer. Research and development studies have become increasingly important for the strategy of preventing MDR. There is a need for new multitarget drug research and advancement to reduce the development of drug resistance in drug-drug interactions and reduce cost and toxic effects. This study aimed to determine the effects of multi-target triazene compounds on antibacterial, antifungal, antiviral, cytotoxic, and larvicidal activities were investigated in vitro. A series of 12 novel of 1,3-diaryltriazene-substituted sulfadiazine (SDZ) derivatives were synthesized, and the obtained pure products characterized in detail by spectroscopic and analytic methods (FT-IR, 1H-NMR, 13C-NMR, and melting points). The antibacterial and antifungal activities of these derivatives (AH1-12) were determined by broth microdilution method. All derivatives have been evaluated in cell-based assays for cytotoxic and antiviral activities against Modified Vaccinia Virus Ankara. The larvicidal efficacy of these chemical compounds was also investigated by using Lucilia sericata (L. sericata) larvae. Twelve 1,3-diaryltriazene-substituted SDZ derivatives (AH1-12) were designed and developed as potent multitargeted compounds. Among them, the AH1 derivative showed the most antibacterial and antifungal activity. Besides, synthesized derivatives AH2, AH3, AH5, and AH7 showed higher antiviral activity than SDZ. All synthesized derivatives showed higher cytotoxic activity than SDZ. Also, they showed larvicidal activity at 72 h of the experiment. As a result, these compounds might be great leads for the development of next-generation multitargeted agents. 相似文献
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《Bioorganic & medicinal chemistry》2016,24(22):5796-5803
A series of 1,3-disubstituted 2-iminobenzimidazolines as well as a number of their tautomeric analogs were synthesized. The synthesized compounds were tested for their cytotoxicity against MDCK cells and for inhibiting activity against influenza virus A/California/07/09 (H1N1)pdm09. Based on the results obtained, 50% cytotoxic concentration (CC50), 50% inhibiting concentration (IC50) and selectivity index (SI) were calculated for each compound. It was found that some of synthesized benzimidazole derivatives (7 of 22, 32%) possess strong virus-inhibiting activity against pandemic influenza virus (IC50’s in low micromolar range) with quite moderate cytotoxicity (CC50 in the range of thousands micromoles). Due to their high selectivity (highest SI’s = 50–83) these compounds are of significant interest for further in vivo experiments as well as for further structural optimization and drug development. 相似文献