Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation

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Resurrection of endogenous retroviruses during aging reinforces senescence

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A hyper-quiescent chromatin state formed during aging is reversed by regeneration

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Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

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Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis

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NAD+ Repletion Rescues Female Fertility during Reproductive Aging

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Restoration of CPEB4 prevents muscle stem cell senescence during aging

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A Single-Cell Transcriptomic Atlas of Human Skin Aging

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Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

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Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration

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Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

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White matter aging drives microglial diversity

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Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging

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Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner

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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging

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Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

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53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

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Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues

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IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2

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