共查询到20条相似文献,搜索用时 15 毫秒
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《Microbes and infection / Institut Pasteur》2015,17(8):549-556
Alzheimer's disease (AD) is a leading cause of dementia among elderly. Yet, its etiology remains largely unclear. In this review, we summarize studies that associate systemic infection and neuroinflammation with AD, while highlighting that early-life or life-long exposure to infectious agents predisposes one to develop AD at a later age. 相似文献
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Inflammation, Immunity, Vaccines for Helicobacter Infection 总被引:1,自引:0,他引:1
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L J Bruce-Chwatt 《BMJ (Clinical research ed.)》1984,288(6433):1782-1783
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Infectious Bovine Rhinotracheitis Virus Infection in Bulls, with Special Reference to Preputial Infection 总被引:5,自引:0,他引:5 下载免费PDF全文
V. Bitsch 《Applied microbiology》1973,26(3):337-343
In an experiment with infectious bovine rhinotracheitis (IBR) virus in two bulls, observed over a period of 122 weeks, the pattern of virus release was studied. Recurrent, unprovoked release of virus was demonstrated after one year in a nasal washing from one of the bulls and in preputial washings of both on 13 and 4 occasions, respectively, and finally in weeks 113 and 110, although clinical disease was not observed. During periods of recurrent virus release, concentrations of virus in the prepuce were generally much lower than during the period of primary infection; usually, however, they were not of negligible titer. The frequency of such periods and the virus titers observed strongly suggest that an IBR antibody carrier should always be considered as a potential source of infection to other animals. When virus was demonstrated in semen an almost equal amount was found in the preputial washing (50 ml). In week 120, virus replication in the respiratory tract and prepuce was induced in both bulls by prednisolone injections. It is concluded that antibody carriers will rarely attain a state of absolute immunity. 相似文献
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Inflammation, Immunity, and Vaccines for Helicobacter Infection 总被引:4,自引:0,他引:4
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Menendez C 《Parasitology today (Personal ed.)》1998,14(12):503
edited by L. Southgate, C. Lockie, S. Heard and M. Wood, Oxford University Press, 1997. pound27.50 (476 pages) ISBN 0 919 262092 4. 相似文献
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Kung‐Jong Lui 《Biometrical journal. Biometrische Zeitschrift》2000,42(1):59-69
This paper discusses interval estimation of the simple difference (SD) between the proportions of the primary infection and the secondary infection, given the primary infection, by developing three asymptotic interval estimators using Wald's test statistic, the likelihood‐ratio test, and the basic principle of Fieller's theorem. This paper further evaluates and compares the performance of these interval estimators with respect to the coverage probability and the expected length of the resulting confidence intervals. This paper finds that the asymptotic confidence interval using the likelihood ratio test consistently performs well in all situations considered here. When the underlying SD is within 0.10 and the total number of subjects is not large (say, 50), this paper further finds that the interval estimators using Fieller's theorem would be preferable to the estimator using the Wald's test statistic if the primary infection probability were moderate (say, 0.30), but the latter is preferable to the former if this probability were large (say, 0.80). When the total number of subjects is large (say, ≥200), all the three interval estimators perform well in almost all situations considered in this paper. In these cases, for simplicity, we may apply either of the two interval estimators using Wald's test statistic or Fieller's theorem without losing much accuracy and efficiency as compared with the interval estimator using the asymptotic likelihood ratio test. 相似文献