A conformational change in the N terminus of SLC38A9 signals mTORC1 activation

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DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

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Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

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Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology

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UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

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Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport,generating compositionally diverse Importin β-1 granules

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High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation

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Behavioral circatidal rhythms require Bmal1 in Parhyale hawaiensis

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Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity

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Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4

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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly

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Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9

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Cas9 deactivation with photocleavable guide RNAs

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Structural basis for Cas9 off-target activity

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Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies

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Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development

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Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner

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Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

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