Catalytic cycling of human mitochondrial Lon protease

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Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1

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HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity

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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1

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The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48

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Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes

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The Non-dominant AAA+ Ring in the ClpAP Protease Functions as an Anti-stalling Motor to Accelerate Protein Unfolding and Translocation

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BacPROTACs mediate targeted protein degradation in bacteria

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Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation

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Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

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Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing

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Katanin Grips the β-Tubulin Tail through an Electropositive Double Spiral to Sever Microtubules

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XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

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CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection

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Active experience,not time,determines within-day representational drift in dorsal CA1

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Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells

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Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER

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Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry

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Highlights

• •All six binding sites in PAN^WT are occupied by ADP- or ATP-type nucleotides.
• •PAN^KA Walker A mutant substoichiometrically binds ATP- but not ADP-type nucleotides.
• •PAN hexamer dissociation of the solution origin characteristics was observed in MS.
• •We posit that the PAN hexamer dissociation proceeds within the ESI droplets.

     

Alteration in information flow through a pair of feeding command neurons underlies a form of Pavlovian conditioning in the Drosophila brain

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