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1.
Olusi S Al-Awadhi A Abiaka C Abraham M George S 《Biological trace element research》2003,91(2):137-144
Leptin, the obesity gene protein product, is a hormone with multiple physiological functions in the human. However, there
are few reports in the literature on its role in trace element metabolism in the normal population. Therefore, we investigated
the association among serum leptin, zinc, copper, and zinc/copper ratio in 570 healthy men and women aged 15 yr and older.
Serum leptin assay was done with a commercial enzymelinked immunosorbent assay kit; serum zinc and copper levels were measured
by an atomic absorption spectrophotometer. Serum leptin was found to be positively associated with age (r=0.254, p<0.001), sex (r=0.406, p<0.001), body mass index (BMI) (r=0.553, p<0.001), and serum copper (r=0.419, p<0.001), but negatively associated with the zinc/copper ratio (r=−0.423, p<0.001). There was no significant association between serum leptin and zinc (r=−0.131, p>0.05). When the confounding effects of age, sex, and BMI were removed, serum leptin was still positively associated with
serum copper (r=0.197, p=0.02) and the serum zinc/copper ratio (r=−0.182, p=0.03). These results suggest that copper and not zinc has an effect on serum leptin levels. 相似文献
2.
The concentrations of cadmium, lead, selenium, and zinc in blood and seminal plasma were determined in 76 Singapore males.
Except for zinc, the concentrations were generally higher in blood than in seminal plasma (cadmium, 1.31 μg/L vs 0.61 μg/L;
lead, 82.6 μg/L vs 12.4 μg/L, and selenium, 163.6 μg/L vs 71.5 μg/L). The mean concentration of zinc in seminal plasma was
more than 30 times higher than in blood (202 mg/L vs 6.2 mg/L). Significant positive correlations were found between the concentrations
in blood and seminal plasma for the two essential trace elements: selenium (r=0.45,p<0.001) and zinc (r=0.25,p<0.05). However, no relationships were found between the concentrations in blood and seminal plasma for two toxic metals (cadmium
and lead). Significant inverse correlations were observed between Cd and Zn (r=−0.40,p<0.01), and Pb and Se (r=−0.32,p<0.05) in blood, whereas significant positive correlations were noted between Cd and Se (r=0.45,p<0.01), Cd and Zn (r=0.35,p<0.05), and Se and Zn (r=0.57,p<0.001) in seminal plasma. The physiological significance of these relationships are also discussed in this paper. 相似文献
3.
Women with preeclampsia have been shown to have elevated blood levels of the metabolite homocysteine, and alterations in blood
levels of zinc and copper have also been reported. This study measured plasma levels of zinc, copper, and homocysteine in
women with preeclampsia and in women with healthy, normotensive pregnancies.
For the patients with preeclampsia compared with controls, significantly higher mean plasma levels were found of homocysteine
(16.39 vs 9.45 nmol/mL; p≤0.001), zinc (15.53 vs 11.93 μg/g protein; p < 0.05), and copper (47.90 vs 31.60 μg/g protein; p=0.001). The ratio of plasma Cu/Zn levels tended to be higher in preeclamptic women and could be taken as an index of inflammatory
reaction, but the difference was not significant. Homocysteine concentrations correlated positively with plasma zinc concentrations
in women with preeclampsia (r=0.588, p=0.003) but not in women with healthy pregnancies. No correlations were observed between plasma levels of homocysteine and
copper.
Thus, the present study found evidence that preeclampsia might be associated with hyperhomocysteinemia and elevated blood
levels of zinc and copper. Furthermore, elevated blood levels of zinc were significantly associated with hyperhomocysteinemia
in preeclampsia. More studies are warranted to investigate further any relationship between altered homocysteine metabolism
and levels of zinc and copper in preeclampsia. 相似文献
4.
Casimiro-Lopes G de Oliveira-Junior AV Portella ES Lisboa PC Donangelo CM de Moura EG Koury JC 《Biological trace element research》2009,127(2):109-115
The purpose of this study was to compare plasma leptin, plasma zinc, and plasma copper levels and their relationship in trained
female and male judo athletes (n = 10 women; n = 8 men). Blood samples were obtained 24 h after training to measure plasma zinc, copper, and leptin levels. Subjects presented
similar values to age (22 ± 2 years old), body mass index (24 ± 1 kg/m2), plasma zinc (17.2 ± 2 μmol/L), copper (12.5 ± 2 μmol/L), and leptin (5.6 ± 1.3 μg/L). However, height, total body mass,
lean mass, fat mass, and sum of ten-skinfold thickness were higher in male than female. Plasma leptin was associated with
sum of ten skinfolds in male (r = 0.91; p < 0.001) and female athletes (r = 0.84; p < 0.003). Plasma zinc was associated with leptin in males (r = 0.82; p < 0.05) while copper was associated with plasma leptin in females (r = 0.66; p < 0.05). Our results suggest that young judo athletes lost sex-related differences in leptin levels. Plasma zinc, plasma
copper, and energy homeostasis may be involved in regulation of plasma leptin. 相似文献
5.
Tubek S 《Biological trace element research》2006,114(1-3):55-63
The relationship between selected zinc (Zn) metabolism parameters, arterial blood pressure, age, and renin-angiotensin-aldosterone
system in subjects of both sexes with mild primary arterial hypertension is presented in this study. The following parameters
were measured: systolic and diastolic arterial blood pressure, total and ouabain-dependent efflux rate constants of Zn from
lymphocytes, serum and lymphocyte Zn concentrations, serum aldosterone, angiotensin-converting enzyme, sodium and potassium
concentrations, body mass index, and plasma rennin activity. When all subjects are taken into account, no significant age-related
differences were found for serum Zn. If divided into men and women, negative (r=−0.39) and positive (r=0.34) correlations are observed, respectively. Lymphocyte Zn correlated negatively with age in the entire group (r=−0.55) and also for men (r=−0.54) and women (r=−0.57).
The renin-agiotensin-aldosterone system parameters correlated with those of Zn metabolism only for women: plasma rennin activity
with total Zn efflux from lymphocytes (r=−0.33) and with lymphocyte Zn (r=0.71); the angiotensin-converting enzyme with total Zn efflux from lymphocytes (r=−0.35), with the oubain-dependent Zn efflux from lymphocytes (r=−0.33) and with lymphocyte Zn (r=0.57); serum aldosterone with oubain-dependent Zn efflux from lymphocytes (r=−0.44) and with lymphocyte Zn (r=0.59). For the men, the only positive correlation was that of serum Zn and aldosterone (r=0.45). In all cases (men and women), there was no negative correlation between serum Zn and angiotensin-converting enzyme.
In women, the diastolic blood pressure correlated negatively with total Zn efflux from lymphocytes (r=−0.39), oubain-dependent Zn efflux from lymphocytes (r=−0.49), and serum Zn (r=−0.46); systolic blood pressure correlated negatively with lymphocyte zinc (r=−0.38). In men, the systolic blood pressure had a negative correlation with lymphocyte zinc (r=−0.32), which was also true for the entire group (r=−0.34). These results clearly show gender-related differences in Zn metabolism and indicate the need for further research
to elucidate the possible causes of this phenomenon not only for Zn but for other elements as well. 相似文献
6.
Carmiña L. Vargas Zapata Tania M. R. Simões Carmen M. Donangelo 《Biological trace element research》1997,57(2):115-124
Erythrocyte metallothionein (E-MT) is considered a promising index of zinc status in humans, since it may be more sensitive
than other biochemical indices to changes in dietary zinc. However, conditions of high zinc demand with substantial redistribution
of tissue zinc and specific changes in hormone profile, such as pregnancy, may have an influence on E-MT levels in addition
to dietary zinc. In this study, we compared E-MT concentrations in relation to other biochemical zinc indices in healthy pregnant
women at delivery (n=40) and nonpregnant women (n=22) with similar habitual dietary zinc intakes (average 13.3 mg/d). Pregnant women had lower serum zinc and albumin-bound
serum zinc, but higher levels of {ie115-1}-macroglobulin-bound serum zinc than the nonpregnant women. Erythrocyte zinc (E-Zn)
was similar in both groups, but E-MT (mean±SE) was slightly but significantly (p<0.05) higher in the pregnant women (2.9±0.09 nmol/g protein) compared to nonpregnant women (2.6±0.06 nmol/g protein). A significant
correlation was observed between E-MT and E-Zn in the nonpregnant women (r=0.70;p<0.001), consistent with the role of intracellular zinc in the regulation of metallothionein synthesis. However, such correlation
was not observed in the pregnant women, suggesting that E-MT levels in pregnancy may be influenced by factors related to the
pregnant state. 相似文献
7.
Lucianna Fernandes J. C. Marques Carmen Marino Donangelo Juliana Gastao Franco Luciane Pires Aderval Severino Luna Gustavo Casimiro-Lopes Patricia Cristina Lisboa Josely Correa Koury 《Biological trace element research》2011,142(3):415-423
Intense physical activity is associated with biological adaptations involving hormones and trace elements. Zinc supplementation
may affect plasma copper concentration, thyroid-stimulating hormone (TSH), thyroid hormones, insulin, and glucose homeostasis,
but data in athletes are scarce. The aim of this study was to evaluate in competitive athletes (cyclists, n = 7, 32 ± 8 years) the effect of zinc supplementation (22 mg/day as zinc gluconate) during 30 days, and discontinuation using
placebo (maltodextrin) during the following 30 days, on plasma zinc and copper concentrations, serum thyroid hormones, insulin
and glucose levels, and HOMA2-IR. Compared to baseline, plasma zinc and Zn:Cu plasma ratio increased, but plasma copper decreased
after zinc supplementation (day 30) and discontinuation (day 60) (p < 0.05). Zn supplementation and discontinuation had no effect on TSH, T3, and T4. Fasting serum insulin and HOMA2-IR increased
(27% and 47%, respectively) on day 60 compared to baseline (p = 0.03), suggesting a delayed effect of zinc supplementation. Moreover, plasma zinc was positively associated with serum
insulin (r = 0.87, p = 0.009) and HOMA2-IR (r = 0.81, p = 0.03) after zinc supplementation (day 30), indicating that supplemental zinc may impair glucose utilization in cyclists. 相似文献
8.
Hee Y. Paik Hyojee Joung Joo Y. Lee Hong K. Lee Janet C. King Carl L. Keen 《Biological trace element research》1999,69(1):45-57
The present study focused on whether serum extracellular superoxide dimutase (EC-SOD) activity can be used as a functional
indicator of marginal zinc deficiency in humans. Subjects in this study were 444 healthy adults over 30 yr of age living a
normal rural life in Kyunggi province, Korea. The mean dietary zinc intake of subjects obtained from one 24-h recall was 6.41
± 4.35 mg and the average serum zinc concentration of the subjects was 11.06 ± 2.44 (μmol/L. Subjects were divided into three
groups by serum zinc concentrations: adequate (serum zinc >10.7 (μmol/L), low (serum zinc 9.0–10.7 μmol/L), and very low (serum
zinc <9.0 μmol/L) groups. A total of 50 subjects were selected from the three groups for analysis of EC-SOD activities. The
EC-SOD activity of subjects increased with increasing serum zinc concentrations, and the activities of the three groups were
significantly different as indicated by the Kruskal-Wallis test (p = 0.0239). Also, serum EC-SOD activities were significantly
correlated with serum zinc concentrations (r = 0.289,p = 0.04). Serum EC-SOD activities, however, were not significantly correlated to the dietary zinc intakes. In conclusion,
these results show that EC-SOD activities are decreased in subjects with low serum zinc concentrations and suggest that EC-SOD
activity may be a functional indicator of zinc nutritional status in humans. 相似文献
9.
Reza Amani Somaye Saeidi Zahra Nazari Sorour Nematpour 《Biological trace element research》2010,137(2):150-158
It has been suggested that mood disorders and depressive status may be accompanied by lowered zinc status in the body, and
adequate consumption of zinc increases a general perceived well-being. The main objective of this study was to assess the
correlation between serum zinc concentrations and dietary zinc intakes with depression scores in university female students.
In the first phase, Beck's depression questionnaire was applied in a random sampling of 308 selected 20–25-year-old female
students (one third of total students in Ahvaz Jondi-Shapour University of Medical Sciences Golestan dormitories) to assess
the major depressive disorder (MDD) scales. Then, in the second phase, 23 students who identified as having moderate and severe
depression were selected as the case group, and 23 healthy age matched were chosen as the controls. Each of them completed
a 12-item semiquantitative food frequency questionnaire containing the main food sources of zinc in the usual dietary patterns
and also a 24-h food recall questionnaire to assure the daily zinc intakes. Daily zinc intakes were obtained by multiplying
each portion size by its zinc content using food tables. A 5-ml blood sample was taken for further serum zinc status using
flame atomic absorption spectrophotometry technique. Pearson's r was used to show the correlation between quantitative variables. Both daily zinc intake and serum zinc concentrations of
MDD group were about two thirds of healthy index (p < 0.01). Depressed individuals used to eat lower servings of red meats and chicken as the main food sources of zinc in students'
usual diets (p < 0.001). Consumption of other foods as the sources of zinc was not significantly different in two groups. A linear significant
correlation between dietary zinc intakes and its serum levels was seen in samples (r = 0.62; p < 0.001) and MDD students (r = 0.55; p < 0.001). There was a linear inverse correlation between Beck questionnaire scores and serum zinc concentrations in all of
the investigated students(r = -0.65; p < 0.001) and MDD girls (r = −0.71; p < 0.001). Beck questionnaire scores and diatary zinc intakes were also inversly correlated (r = −0.58; p < 0.001). However, no statistical correlation was seen between these two variables in MDD cases. In depressed female students,
dietary zinc intake is correlated to its serum concentrations; however, the serum zinc levels are inversely correlated to
depression scales. Consumption of the main dietary sources of zinc such as red meats and chicken should be encouraged in young
depressed girls. 相似文献
10.
Abdellatif Chakar Ridha Mokni Philip A. Walravens Philippe Chappuis Fanny Bleiberg-Daniel Jean-Louis Mahu Daniel Lemonnier 《Biological trace element research》1993,38(1):97-106
Plasma zinc, copper, and parameters of growth were measured in a group of 116 French preschool children, 2–5 yr-old from low-income
households. Participants were selected on the basis of Z-scores of weight for height (WHZ) and height for age (HAZ). Zinc
and copper concentrations of children with growth impairment (GI), defined by a WHZ and/or HAZ< −1 Z-score, were compared
to those of age, sex, and ethnic origin matched controls (WHZ and HAZ >−1 Z-score). Mean (±SD) plasma zinc concentration was
12.58±1.84 μmol/L in the GI group, and 13.27±1.98 μmol/L in the controls. The difference of the means of paired samples was
0.69±2.34, and by pairedt-test the significance reachedp=0.028. This effect was primarily a result of the weight retarded group (WHZ <−1 Z-score,p<0.009) and to the girls (p<0.05). There were no significant differences in plasma copper concentrations between groups. These results suggest the presence
of marginal zinc deficiency in French preschool children with low weight for height Z-scores. 相似文献
11.
The aim of the present study is to evaluate the status of plasma essential trace elements selenium (Se), zinc (Zn), copper
(Cu), and iron (Fe) concentrations and their related acute-phase proteins, ceruloplasmin (Cp), ferritin, transferrin (Tf),
and albumin levels in patients with vivax malaria. Plasma Cu and Zn concentrations were determined by atomic absorption spectrometry
(AAS). Se concentrations were determined by graphite furnace AAS. Fe, Cp, Tf, and albumin levels were determined by colorimetric
methods. Plasma Se, Fe, and albumin levels were found to be significantly lower (p<0.01, p<0.001, and p<0.05, respectively) and Cu, Cp, and ferritin levels and Cu/Zn ratios were significantly higher (p<0.001, p<0.001, p<0.001, and p<0.05, respectively) in patients when compared with those of healthy subjects. Plasma, Tf, and Zn levels were not found to
be significantly different (p>0.05) in patients and controls. There were positive important correlations between Cu and Cp (r=0.908, p<0.001), Zn and albumin (r=0.633, p<0.001), and negative correlations between Fe and ferritin content (r=−0.521, p<0.05) and Fe and Tf (r=−0.616, p<0.01) in the patients group. Our findings demonstrated that plasma essential trace elements Se, Cu, and Fe change, but these
changes might be dependent on acute-phase proteins, which were regulated as a part of defense strategies of the organism,
induced by hormonelike substances. 相似文献
12.
The aim of the present study is to evaluate the status of plasma essential trace element selenium (Se), manganese (Mn), copper
(Cu), zinc (Zn), and iron (Fe) concentrations and the effect of these elements on oxidative status in patients with childhood
asthma. Plasma Se, Mn, Cu, and Zn concentrations were determined by atomic absorption spectrophotometry (AAS) and Fe concentrations,
malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined by the colorimetric method. The plasma MDA/TAC
ratio was calculated as an index of oxidative status. Plasma albumin levels were measured to determine nutritional status.
Plasma Fe concentrations, MDA levels and the MDA/TAC ratio were significantly higher (p<0.001, p<0.001, and p<0.01, respectively) and Se and Mn concentrations and TAC were lower (p<0.01, p<0.05, and p<0.01, respectively) in patients when compared to the healthy subjects. Plasma Zn, Cu, and albumin levels were not found to
be significantly different in patients and controls (p>0.05). There were positive relationships between plasma MDA and Fe (r=0.545, p<0.001) and TAC and Se (r=0.485, p<0.021), and a negative correlation between TAC and MDA values (r= −0.337, p<0.031) in patients with childhood asthma. However, there was no correlation between these trace elements and albumin content
in patient groups. These observations suggest that increased Fe and decreased Se concentrations in patients with childhood
asthma may be responsible for the oxidant/antioxidant imbalance. 相似文献
13.
Jean-Frédéric Brun Christine Dieu-Cambrezy Alain Charpiat Colette Fons Christine Fedou Jean-Paul Micallef Michelle Fussellier Lucette Bardet André Orsetti 《Biological trace element research》1995,47(1-3):273-278
Serum zinc was measured in 20 adolescent gymnasts (9 boys, 11 girls, age 12–15 yr) explored for detecting possible adverse
effects of intense training on pubertal maturation and growth. They had low serum zinc (0.599±0.026 mg/L) when compared to
matched control sedentary children (n=118 mean 0.81±0.014p<0.001). Girls had lower zinc than boys (0.557±0.023 vs 0.651±0.044p<0.001). Zinc was correlated to isometric adductor strength (r=0.468p<0.05). Children with serum zinc <0.6 mg/L had lower insulin-like growth factor binding protein 3 than others (2.326±0.264
vs 2.699±0.12p<0.01). Thus, zinc is lowered in trained adolescent gymnasts and even lower in females. This reduction could play some role
in abnormalities of puberty, growth, or muscular performance. 相似文献
14.
Turgut M Yenisey C Akyüz O Ozsunar Y Erkus M Biçakçi T 《Biological trace element research》2006,109(2):123-134
The aim of our study was to assess the blood concentrations of some trace elements and melatonin (MLT) in patients with intervertebral
disc herniation (IDH) and to investigate the interaction of histological and biochemical degeneration findings with aging.
The present study was carried out on 13 subjects (8 women and 5 men) diagnosed with IDH. They were divided into three groups
according to their ages. Nighttime serum MLT, zinc (Zn), and magnesium (Mg) levels were determined in all patients. In addition,
computed tomography (CT) scan of the brain and magnetic resonance imaging examination of the lumbar spine were obtained in
this study. The Zn level and Zn/Mg ratio showed a decline in patients with IDH with aging, whereas the serum Mg level and
tissue hydroxyproline content increased. A positive correlation between serum Zn and MLT concentrations was found (r=0.104, p=0.734). In addition, there was a positive correlation between serum Zn level and Zn/Mg ratio (r=0.835 and p<0.01), and a negative correlation between serum Mg level and Zn/Mg ratio (r=−0.571, p<0.05). On CT study, both volume percentage of calcified pineal gland and density of calcification were found to increase
progressively with advancing age. The results of semiquantitative evaluation of disc tissues of patients with IDH for histological
degeneration findings showed that 66.7% of discs treated had slight degeneration in younger age group, but 75.0% and 100%
of discs had moderate or marked degeneration in older age groups. Our data indicated that there is a close relationship between
MLT and Zn or Mg levels in the serum samples of patients with IDH, and the levels of these elements might be affected by the
presence of degeneration process and serum MLT level, or vice versa. 相似文献
15.
Koury JC de Oliveira Kde J Lopes GC de Oliveira AV Portella ES de Moura EG Donangelo CM 《Biological trace element research》2007,115(1):23-30
This study evaluated levels of plasma zinc, copper, and leptin, body composition, and their relationship in nine elite female
judo athletes under two different training conditions. Body composition and biochemical measurements (hematological indexes,
plasma zinc, plasma copper, and plasma leptin) were analyzed 24 h after intense training and following a 5-d period without
training (no-training). Plasma leptin and plasma zinc increased with no-training. Plasma zinc correlated negatively with percent
fat mass (r=−0.62; r=0.05) and positively with plasma leptin (r=0.83; p=0.002) in the no-training condition Plasma copper did not change during the study and correlated positively with plasma leptin
(r=0.66; p=0.05) and with percent fat mass (r=0.80; p=0.007) after training. Percent fat mass was associated negatively with plasma zinc (r=−0.62; p=0.05) in the no-training condition. Moreover percent fat mass was negatively associated with the Zn/Cu plasma ratio under
both training conditions (r<−0.78, p<0.001). These results are consistent with the possible function of zinc as a lipid-mobilizing factor and of copper
as a limiting factor in energy metabolism. 相似文献
16.
Markus P. Look Jürgen K. Rockstroh Govind S. Rao Karl A. Kreuzer Ulrich Spengler Tilman Sauerbruch 《Biological trace element research》1997,56(1):31-41
Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers
for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7±12.2 μg/L;p<0.01;n=18) and stage III (47.6±11.3 μg/L;p<0.01;n=19) HIV-infected patients, than in healthy subjects (80.6±9.6 μg/L;n=48) and stage I patients (73.6±16.5 μg/L;n=20). Serum selenium levels were positively correlated with CD4 count, CD4/8 ratio, hematocrit, and serum albumin (r=0.42;r=0.39;r=0.48; andr=0.45;p<0.01, respectively) and inversely with serum levels of thymidine kinase (r=−0.49;p<0.01;n=49) and β2-microglobulin (r=−0.46;p<0.001;n=49). In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I:n=10; CDC II:n=10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors
(sTNFR) types I and II. There was no correlation with serum immuneglobulin A and total serum protein levels. The results show
that the progressive deprivation of serum selenium in HIV-infection is associated with loss of CD4+-cells and with increased levels of markers of disease progression and inflammatory response. 相似文献
17.
Neural tube defects are important causes of infant mortality and childhood morbidity. We investigated the relationship between
zinc, selenium, copper, and lead concentrations and neural-tube-defect occurrence in women with a second-trimester termination
due to fetal-neural-tube defects (NTDs) in this case-control study. Fourteen pregnant women whose pregnancies were terminated
as a result of second-trimester ultrasonographic diagnosis of neural tube defects were recruited as cases. The control group
(n=14) consisted of women who were selected among age-, gravidity-, and socio-economic-state (SES)-matched women who had a normal
triple-screen and targeted ultrasound during the second trimester with documented normal fetal outcome. Zinc and copper determinations
were made using flame atomic absorption spectrophotometer (AAS). Graphite furnace AAS was used for Pb, and Se levels were
measured with hydride generation AAS. Cases had significantly low serum zinc and selenium levels (62.48±15.9 vs 102.6±23.7
and 55.16±11.3 vs 77.4±5.5, respectively, p<0.001). Serum Cu and whole-blood Pb levels were significantly high when compared to controls. There was a negative correlation
between serum zinc and selenium levels, and serum copper levels (r=−425 and −0.443, p<0.05). Our results are consistent with some previous reports. The etiology of NTDs cannot be explained with one strict etiologic
mechanism. On the contrary, an interaction among environmental, genetic, and nutritional factors such as trace elements and
vitamins would explain these anomalies. If folic acid supplementation is given, additional Zn supplementation should be considered
for the further decrease in the recurrence and occurrence of NTDs. 相似文献
18.
Monica Daniela Doşa Laurentiu-Tony Hangan Eduard Crauciuc Cristina Galeş Mihai Nechifor 《Biological trace element research》2011,142(1):36-46
Research was performed on a group of 30 patients with non-insulin-dependent diabetes mellitus (NIDDM), who never received
antidiabetic medication before, and on a group of 17 healthy adults. The patients were administered treatment with metformin,
1,000 mg/day. Plasmatic and urinary concentration of magnesium have been measured, copper and zinc along with the concentrations
of glucose, HDL, LDL, cholesterol, tryglicerides, HbA1c, and total erythrocyte magnesium, in advance and after 3 months of
treatment. Data showed significant differences in the NIDDM group vs the control group: for plasma magnesium—1.95 ± 0.19 vs
2.20 ± 0.18 mg/dl, p < 0.001; urine magnesium—237.28 ± 34.51 vs 126.25 ± 38.22 mg/24 h, p < 0.001; erythrocyte magnesium—5.09 ± 0.63 vs 6.38 ± 0.75 mg/dl, p < 0.001; plasma zinc—67.56 ± 6.21 vs 98.41 ± 20.47 μg/dl, p < 0.001; urine zinc—1,347.54 ± 158.24 vs 851.65 ± 209.75 μg/24 h, p < 0.001; plasma copper—111.91 ± 20.98 vs 96.33 ± 8.56 μg/dl, p < 0.001; and urine copper—51.70 ± 23.79 vs 36.00 ± 11.70 μg/24 h, p < 0.05. Treatment with metformin for 3 months modified significant erythrocyte magnesium—5.75 ± 0.61 vs 5.09 ± 0.63 mg/dl,
p < 0.001 and urine magnesium—198.27 ± 27.07 vs 237.28 ± 34.51 mg/24 h, p < 0.001, whereas it did not modify significant the plasmatic and urinary concentration of the other cations. The erythrocyte
magnesium concentration was inversely correlated with HbA1c (r = −0.438, p = 0.015). The plasma level of copper was positively correlated with HbA1c (r = 0.517, p < 0.003), tryglicerides (r = 0.534, p < 0.003), and cholesterol (r = 0.440, p < 0.05), and the plasma level of zinc was inversely correlated with glycemia (r = −0.399, p = 0.029). Our data show a significant action of metformin therapy, by increasing the total intraerythrocyte magnesium concentration
and decreasing the urinary magnesium elimination, positively correlated with the decrease of glycemia and HbA1c in NIDDM patients. 相似文献
19.
Ferro FE de Sousa Lima VB Soares NR de Sousa Almondes KG Pires LV Cozzolino SM do Nascimento Marreiro D 《Biological trace element research》2011,143(2):787-793
Alterations in antioxidant defense in obese people with metabolic syndrome can contribute to oxidative stress. This study
assessed the relationship between the parameters of metabolic syndrome and the zincemia, activity of superoxide dismutase,
and glutathione peroxidase enzymes in obese women. Seventy-three premenopausal women, aged between 20 and 50 years, were divided
into two groups: case group, composed of obese (n = 37), and control group, composed of no obese (n = 36). Analyses of zinc intake, parameters of metabolic syndrome, plasma, and erythrocyte zinc, and activities of superoxide
dismutase and glutathione peroxidase were carried out. The mean values of body mass index of obese women and control group
were 34.5 ± 3.4 and 21.7 ± 1.9 kg/m2, respectively (p < 0.05). In the study, body mass index, waist circumference, and zinc intake were higher in obese women than control group
(p < 0.05). The plasma zinc and activity of superoxide dismutase did not show significant differences between obese and controls
(p > 0.05). The values of erythrocyte zinc was 36.4 ± 15.0 μg/gHb and 45.4 ± 14.3 μg/gHb and of glutathione peroxidase was 46.4 ± 19.4 U/gHb
and 36.7 ± 13.6 U/gHb in obese women and controls, respectively (p < 0.05). The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations
in erythrocytes. Regression analysis demonstrates that the erythrocyte zinc and activity of superoxide dismutase enzyme is
influenced by components of the metabolic syndrome, and the plasmatic glucose, body mass index, and waist circumference have
a negative correlation with this enzyme. 相似文献
20.
The serum concentrations of copper, zinc, iron, and cobalt and copper/zinc ratio were investigated in horses infected with
equine herpesvirus-1 (EHV-1). Nine horses were naturally infected with the virus and nine healthy horses served as controls.
The concentrations of copper, zinc, iron, and cobalt were determined spectrophotometrically in the blood serum of all horses.
The results were (expressed in micrograms per deciliters) copper 2.80 ± 0.34 vs 1.12 ± 0.44, zinc 3.05 ± 0.18 vs 0.83 ± 0.06,
iron 2.76 ± 0.17 vs 3.71 ± 0.69, cobalt 0.19 ± 0.37 vs 0.22 ± 0.45, and copper/zinc ratio 0.72 ± 0.38 vs 1.41 ± 0.36 for control
vs infected group, respectively. In conclusion, copper and zinc concentrations of the infected group were lower than the control
group (p < 0.001), whereas iron concentration and the copper/zinc ratio of the infected group were higher than the control group (p < 0.05 and p < 0.001). The cobalt concentration was not found to be statistically different between two groups. It might be emphasized
that copper/zinc ratio was significantly affected by the EHV-1 infection, so it could be taken into consideration during the
course of infection.
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