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1.
Reproductive and survival records (n=2,913) from 313 Chinese-origin and 365 Indian-derived rhesus macaques at the Tulane National Primate Research Center (TNPRC) spanning three generations were studied. Least-squares analysis of variance procedures were used to compare reproductive and infant survival traits while proportional hazards regression procedures were used to study female age at death, number of infants born per female, and time from last birth to death. Chinese females were older at first parturition than Indian females because they were older when placed with males, but the two subspecies had similar first postpartum birth interval (1st PPBI) and lifetime postpartum birth interval (LPPBI). Females that gave birth to stillborn infants had shorter first postpartum birth intervals (1st PPBI) than females giving birth to live infants. Postpartum birth intervals decreased in females from age 3 to 12 but then increased again with advancing age. Chinese infants had a greater survival rate than Indian infants at 30 days, 6 months, and 1 year of age. Five hundred and forty-three females (80.01%) had uncensored, or true records for age at death, number of infants born per female, and time from the birth until death whereas 135 females (19.91%) had censored records for these traits. Low- and high-uncensored observations for age at death were 3 and 26 years for Chinese, and 3 and 23 years for Indian females. Uncensored number of infants born per female ranged from 1 to 15 for Chinese females and 1 to 18 for Indian females. Each of these traits was significantly influenced by the origin×generation interaction in the proportional hazards regression analyses, indicating that probabilities associated with age at death, number of infants born per female, and time from last birth to death for Chinese and Indian females did not rank the same across generations. 相似文献
2.
Fordyce G Jubb TF Fitzpatrick LA Whyte TR Cooper NJ Bolam MJ Haddon DJ Hill F D'Occhio MJ 《Animal reproduction science》2001,65(3-4):193-204
The contraceptive efficacy of an intra-uterine device was evaluated using 218 heifers and 212 cows on three north Australian cattle stations. The heifers were aged approximately 2 years and weighed 250-378 kg; the cows were aged 3-16 years and weighed 256-540 kg. All cattle were non-pregnant, non-lactating Brahmans. At the end of the monsoon (wet) season (April-June 1997), the cattle were allocated by stratified randomisation to the three treatments which were untreated controls (n=59), surgical ovariectomy (n=105), or implantation with a bovine intra-uterine device (BIUD; n=266). All cattle grazed and were managed as one group within each station. They were exposed to bulls (4 per 100 females) from soon after treatment until slaughter approximately 12 months later.The BIUD could not be implanted in 25% of heifers and 8% of cows due to narrow or twisted cervices. Correct placement of the BIUDs appeared to be achieved in 57% of heifers and 72% of cows. At slaughter, the devices were incorrectly positioned in 73% of heifers and 49% of cows into which BIUDs had been inserted and that remained non-pregnant. Uterine perforations by the BIUD were observed in 35 and 45% of these heifers and cows, respectively; most perforations appeared to occur during implantation. Low-grade endometritis was observed at slaughter in most BIUD-implanted animals; 2% had pyometra.BIUD animals did not have significantly different growth to that of control or ovariectomised animals, other than when ovariectomy suppressed growth following surgery. Most animals implanted with BIUDs appeared to have normal ovarian function and animals were observed mating. All ovariectomised animals remained non-pregnant. Over 80% of controls were pregnant within 8 months of exposure to bulls, except heifers at one station where pregnancy rate was restricted to 25% as a result of severe nutritional conditions. Pregnancy was diagnosed in 21% of heifers and 33% of cows with implanted BIUDs. The device remained correctly positioned and with no pregnancy diagnosed in the year following implantation in only 2% of heifers and 14% of cows originally allocated.Because of the difficulties of implanting BIUDs, the high frequency of associated uterine injury, the high pregnancy rate in implanted animals, and that growth was unaffected by the presence of a BIUD, it was concluded that the device had poor contraception efficacy and no growth-promotant effect in Brahman cattle. 相似文献
3.
David J. Waters Seema S. Kengeri Beth Clever Julie A. Booth Aimee H Maras Deborah L. Schlittler Michael G. Hayek 《Aging cell》2009,8(6):752-755
To move closer to understanding the mechanistic underpinnings of sex differences in human longevity, we studied pet dogs to determine whether lifetime duration of ovary exposure was associated with exceptional longevity. This hypothesis was tested by collecting and analyzing lifetime medical histories, age at death, and cause of death for a cohort of canine ‘centenarians’– exceptionally long‐lived Rottweiler dogs that lived more than 30% longer than average life expectancy for the breed. Sex and lifetime ovary exposure in the oldest‐old Rottweilers (age at death, ≥ 13 years) were compared to a cohort of Rottweilers that had usual longevity (age at death, 8.0–10.8 years). Like women, female dogs were more likely than males to achieve exceptional longevity (OR, 95% CI = 2.0, 1.2–3.3; P = 0.006). However, removal of ovaries during the first 4 years of life erased the female survival advantage. In females, a strong positive association between ovaries and longevity persisted in multivariate analysis that considered other factors, such as height, body weight, and mother with exceptional longevity. A beneficial effect of ovaries on longevity in females could not be attributed to resistance against a particular disease or major cause of death. Our results document in dogs a female sex advantage for achieving exceptional longevity and show that lifetime ovary exposure, a factor not previously evaluated in women, is associated with exceptional longevity. This work introduces a conceptual framework for designing additional studies in pet dogs to define the ovary‐sensitive biological processes that promote healthy human longevity. 相似文献
4.
D Anderson P C Jenkinson R S Dewdney A J Francis P Godbert K R Butterworth 《Mutation research》1988,204(3):407-420
Blood samples were taken from 106 individuals (73 males and 33 females) and examined for chromosome aberrations, mitogen-induced blastogenesis and proliferative rate index (PRI). The values obtained were investigated in relation to sex, age, smoking, alcohol consumption and X-ray exposure. In all the parameters, there was shown to be a difference between the mean values for the males and females. The incidence of chromosome aberrations was greater in females than in the males, whereas the mean values of PRI and mitogen-induced blastogenesis were lower in females than in the males. A sex difference has been reported previously in the same population, in that the females were shown to have a higher rate of sister-chromatid exchanges than the males (Anderson et al., 1986; Dewdney et al., 1986). Contraceptive pill usage was not considered to be of importance in the sex difference seen and there was shown to be no significant influence due to age, smoking or alcohol consumption on any of the parameters except that smoking reduced lymphocyte PRI. Males with previous X-ray exposure also showed a lower response to mitogen-induced blastogenesis and had a reduced PRI. 相似文献
5.
D E McLain S M Harper D A Roe J G Babish C F Wilkinson 《Laboratory animal science》1985,35(3):251-255
Demographic data of ferrets from a commercial breeding colony were analyzed for the effects of maternal age, parity and strain on reproductive performance and the frequency of gross congenital abnormalities observed at parturition. Litter size (mean +/- SEM) was found to be greatest for young, primiparous females (10.3 +/- 0.2) and decreased with advancing maternal age and parity to a cohort mean of 8.1 +/- 0.1 for third parity females 16 months of age. Age, parity or strain had no effect on 24-hour neonatal mortality (7%) or mortality from birth to weaning (20%) and an examination of the causes for death suggested that these rates can be reduced. The malformation rate from two cohorts of females whelping at different times of the year was low (less than 1.0%) and not significantly different. A higher frequency of malformed offspring was detected in females of low previous parity (0-2) than in those with three or more. Based on data obtained in this survey, the ferret would seem a valuable alternative, nonrodent species for teratologic investigations using currently recommended protocols. 相似文献
6.
To expand upon the findings that lower mortality was found in Japanese urban areas in contrast to the Western model where in the US and Britain the risk of death was higher in metropolitan areas and conurbations, 22 social life indicators are examined among 46 prefectures in Japan in terms of their effect on age specific mortality, life expectancy, and age adjusted marriage, divorce, and birth rates. The effects of these factors on age adjusted mortality for 8 major working and nonworking male populations, where also analyzed. The 22 social life factors were selected from among 227 indicators in the system of Statistical Indicators on Life. Factor analysis was used to classify the indicators into 8 groups of factors for 1970 and 7 for 1975. Factors 1-3 for both years were rural or urban residence, low income and unemployment, and prefectural age distribution. The 4th for 1970 was home help for the elderly and for 1975, social mobility. The social life indicators were classified form 1 to 8 as rural residence in 1970 and 1975, urban residence, low income, high employment, old age, young age, social mobility, and home help for the elderly which moved from 8th place in 1970 to 1st in 1975. Between 1960-75, rapid urbanization took place with the proportion of farmers, fishermen, and workers declining from 43% in 1960 to 19% in 1975. The results of stepwise regression analysis indicate a positive relationship of urban residence with mortality of men and women except school-aged and middle-aged women, and the working populations, as well as life expectancy at birth for males and females and ages 20 and 40 years for males. Rural residence was positively associated with the male marriage rate, whereas the marriage rate for females was affected by industrialization and urbanization. High employment and social mobility were positively related to the female marriage rate. Low income was positively related to the divorce rate for males and females. Rural residence and high employment were positively related to the birth rate. The birth rate is higher in rural areas. Mortality of professional, engineering, and administrative workers was slightly lower than the total working population, while sales workers, those in farming, fishing, and forestry, and in personal and domestic service had significantly higher mortality. The mortality of the nonworking population was 6-8 times higher than sales, transportation, and communication, and personal and domestic service as well as the total population. 相似文献
7.
A comparison of the subsequent reproduction of heifers that calved for the first time at 2 vs. 3 yr of age was conducted on a purebred Brahman herd from 1971 to 1978 in central Florida. Pregnancy rate, birth rate and weaning rate were obtained on 1,612 animals. Sire of the cow had a significant effect on all three reproduction traits, indicating possible genetic differences in these important traits. Age at first calving (either 2 or 3 yr) had no significant effect on overall reproduction rates; however, subsequent pregnancy and weaning rate was 4% higher in females calving first at 2 yr of age. Thirty-eight percent of the females that became pregnant at 15 to 17 mo of age, weighed 650 to 700 lbs. These heifers had been born early in the previous calving season. It is suggested that Brahmans can be selected to calve at 2 yr of age if good nutrition and management are provided. 相似文献
8.
Naoki Koyama Yukio Takahata Michael A. Huffman Koshi Norikoshi Hisayo Suzuki 《Primates; journal of primatology》1992,33(1):33-47
Over a 30-year period from 1954 to 1983, 975 live births were recorded for Japanese macaque females at the Iwatayama Monkey
Park, Arashiyama, Japan. Excluding unknown birth dates, primiparous mothers gave birth to 185 infants (182 cases with age
of mother known) and multiparous mothers gave birth to 723 infants (603 cases with age of mother known). The peak month of
birth was May with 52.3% of the total births occurring during the period. Multiparous females who had not given birth the
previous year did so earlier than multiparous females who had given birth the previous year and also earlier than primiparous
females. Among the females who had given birth the previous year, females whose infant had died gave birth earlier than females
who had reared an infant the previous year. The offspring sex ratio (1:0.97) was not significantly different from 1:1, and
revealed no consistent association with mother's age. Age-fecundity exhibited a humped curve. The annual birth rate was low
at the age of 4 years but increased thereafter, ranging between 46.7% and 69.0%, at between 5 and 19 years of age, but again
decreased for females between 20 and 25 years of age. Some old females displayed clear reproductive senescence. The infant
mortality within the first year of age was quite low (10.3%) and the neonatal (less than 1 month old) mortality rate accounted
for 49.0% of all infant deaths. There was no significant difference between the mortality rates of male and female infants.
A female's rank-class had no apparent effect on the annual birth rate, infant mortality, and offspring sex ratio. These long-term
data are compared with those from other primate populations. 相似文献
9.
Acrylonitrile (ACN) is a compound widely used in the synthesis of a variety of organic products. It has been found that ACN is carcinogenic in rats, and some epidemiological studies also suggest a possible carcinogenic effect of ACN in humans. The aim of the present study was to assess the effect of ACN exposure on the expression of p53 and p21(WAF1) proteins in vitro as well as in vivo. In vitro ACN exposure of human lung fibroblasts resulted in the induction of both p53 and p21(WAF1) proteins. To evaluate the effect of ACN on the levels of p53 and p21(WAF1) proteins in the blood plasma of ACN-exposed workers, samples from 49 subjects (average age 44 years, 88% males, 12% females) exposed to ACN in the petrochemical industry (ACN concentration ranged from 0.05 to 0.3mg/m(3)) were analyzed. Subjects living in the same area (N=24, average age 43 years, 92% males, 8% females), but not working in the petrochemical industry were used as controls. No significant differences in either p53, or p21(WAF1) levels between the exposed and control groups were found. The expression of p53 was significantly higher in exposed non-smokers as compared with smokers (P=0.02). No effect of GSTM1 and GSTT1 genotypes on the expression of either protein was observed. Subjects with an EPHX high activity genotype had significantly higher p21(WAF1) expression as compared with genotypes with low or medium EPHX activity. We conclude that plasma levels of both proteins are not relevant biomarkers for occupational ACN exposure. 相似文献
10.
Data on age and length at sexual maturity, calving interval, lactation period, and ovulation and pregnancy rates were analysed from 84 female striped dolphin collected during the Mediterranean morbillivirus epizootic. Age was determined by counting growth layer groups in tooth dentine, and reproductive status was determined by the macroscopic examination of the ovaries and the uterus. Age at sexual maturity (ASM) was estimated using two different methods; giving average estimates of 12 and 12.3 years. The average length at sexual maturity was 187 cm and the calving interval was four years. The annual pregnancy rate (APR) was calculated using two different criteria. In the first, only females that were pregnant at the time of death, as evidenced by the presence of a foetus, were incorporated in the calculations. This method gave an estimate of 8.9% as the apparent pregnancy rate of the dolphins killed by the epizootic. The second method incorporated in the calculations females that were pregnant at the time of death and females that had young corpus albicans in the ovaries and a distended uterus. This method is considered to reflect the true pregnancy rate of the population and gave an estimate of 25%. Estimates of ovulation rate (0.401) and lactation period (16 months) were considered to be potentially affected by the disease and, therefore, biased. These estimates reflect a peculiar situation of the diseased dolphins but are useful for comparative purposes. Estimates of ASM and APR, parameters which are not likely to be affected by the disease, differed markedly from those of other Stenella populations and could indicate a density-dependent response, possibly reflecting food limitations. 相似文献
11.
Hitoshi Naraoka Kyoko Ito Michie Suzuki Kunihiko Naito Hideaki Tojo 《Experimental Animals》2006,55(1):1-9
We investigated gender difference in the effects of chronic exposure to human growth hormone (hGH) on cardiac risk biomarkers using transgenic mice with non-pulsatile circulating hGH. Blood plasma was obtained from transgenic and control mice at 8, 12, and 16 weeks of age, and was used for the measurement of hGH and the following cardiac risk biomarkers: total cholesterol (CHO), triglyceride (TG), HDL cholesterol (HDL), LDL cholesterol (LDL), non esterified free fatty acids (NEFA), and lipid peroxides (LPO). The hearts and the livers of transgenic mice were weighed and histopathologically examined, and the results were compared with those of control mice. Transgenic males exhibited higher levels of LDL at 8 and 12 weeks of age and higher levels of LPO at every week of age examined, as compared to those of the control males, while transgenic females exhibited somewhat lower levels of LDL and LPO from 8 to 16 weeks of age, as compared to the control females. The relative heart weight in males increased with aging and was significantly higher in the 16-week-old transgenic males compared to those of the control mice. The present results demonstrate that transgenic males had cardiac risk potential caused by chronic-exposure to hGH as compared to females. The results also show that the present transgenic mouse line is a useful model for the study of gender difference in cardiac disorders caused by hGH. 相似文献
12.
J. J. Petersen 《Journal of nematology》1977,9(4):343-346
The ratio of Octomyomermis muspratti to the host mosquito at the time of exposure had little effect on the ratio of male to female parasites that resulted. However, the ratio of males to females increased as the number of parasites/host increased. Hosts with a single nematode produced fewer than 1% males in comparison with hosts with 8 parasites which produced about 40% males; hosts with 10 or more nematodes generally produced more male than female nematodes. Males of O. muspratti usually emerged before females because of the earlier death of multiply-infected mosquitoes. The size of the host at the time of invasion bad no significant influence on nematode sex ratios. Since mating is apparently necessary for reproduction in O. muspratti, the low male to female ratios that occur will be important in developing successful mass production techniques. 相似文献
13.
Sigmodontine rodents are poorly studied and have not received much attention as a reproductive model. Renewed interest in the South American rodents has been stimulated by their link to endemic diseases that are transmitted to man. Calomys laucha acts as a reservoir of two dangerous viruses: an arenavirus named 'Junin virus', the aetiological agent of Argentinian haemorrhagic fever, and the hantavirus, both of which constitute serious sanitary problems. The aim of this study was to establish suitable conditions to superovulate the vesper mouse, Calomys laucha. We examined the hormonal doses, the time interval between hormones, the time-course of ovulation, and the effect of female age on the response to exogenous hormone administration. Female mice were injected with 5-5, 8-8 or 12-15 IU of PMSG/hCG, 48 h apart, at different age intervals (from 30 to > 120 days old). The best superovulation rate was obtained with 8-8 IU PMSG/hCG. Ovulation started about 10 h post-hCG and was completed during the next 4-5 h, and was achieved irrespectively from the oestrus cycle stage. The number of oocytes was influenced by the age of the females. The youngest females had only a superovulatory response. Females older than 61 days showed both ovulatory and superovulatory responses, although 91-120-day-old females had a high ovulatory response. Most of the oocytes (96.5%) recovered were morphologically normal. The genus Calomys constitutes a reproductive model completely different from conventional laboratory rodents. 相似文献
14.
Nishida T Corp N Hamai M Hasegawa T Hiraiwa-Hasegawa M Hosaka K Hunt KD Itoh N Kawanaka K Matsumoto-Oda A Mitani JC Nakamura M Norikoshi K Sakamaki T Turner L Uehara S Zamma K 《American journal of primatology》2003,59(3):99-121
Demography provides critical data to increase our understanding of the evolution, ecology, and conservation of primate populations. The chimpanzees of the Mahale Mountains National Park, Tanzania, have been studied for more than 34 yr on the basis of individual identification and standardized attendance records. From this long-term study, we derived the following demographic data: The major cause of death was disease (48%), followed by senescence (24%) and within-species aggression (16%). Fifty percent of Mahale chimpanzees died before weaning. The median ages of female life history variables were: first maximal swelling, 10.0 yr (n = 5); emigration, 11.0 yr (n = 11); and first birth, 13.1 yr (n = 5). The median period of adolescent infertility was 2.8 yr (n = 4) when calculated from the age at immigration to that at first birth. Female fecundity was highest between 20 and 35 yr of age, with an annual birth rate of 0.2. Twenty-six females that were observed from a young age (10-13 yr) to death at various ages (15-40 yr) gave birth to an average of 3.9 and weaned an average of 1.4 offspring. Twenty-five females that were observed from middle age (18-33 yr) to death in older age (31-48) gave birth to an average of 2.7 and weaned an average of 2.0 offspring. The post-reproductive lifespan for female chimpanzees was defined as the number of years that passed from the year when the last offspring was born to the year when the female died, minus 5. Twenty-five percent of old females had a post-reproductive lifespan. The interbirth interval after the birth of a son (x = 72 mo) tended to be longer than that after the birth of a daughter (x = 66 mo). The extent of female transfer, which is a rule in chimpanzees, is influenced by the size and composition of the unit group and size of the overall local community. 相似文献
15.
Influences of pre- and postnatal testosterone treatment on defeminization of sexual receptivity in pigs 总被引:1,自引:0,他引:1
Sexual receptivity was evaluated in female and male pigs that had experienced varying periods of exposure to testosterone pre- and postnatally. For prenatal exposure, pregnant sows were treated with testosterone propionate (TP) from Day 29-35 or Day 39-45 of gestation at a dosage that caused virilization of the external genitalia of their female offspring. Eighty-three percent of the females that received TP prenatally had regular estrous cycles, but reached puberty later than control females. Only 26% of the females that received TP both pre- and postnatally (4-6 mo of age) were observed in estrus by 10 mo of age. After ovariectomy and acute treatment with estradiol benzoate (EB), the proportion of females that showed the immobilization response (receptivity) was similar for all groups of females independent of pre- or postnatal TP treatment. Females treated prenatally from Day 39-45 showed the immobilization response for fewer days after treatment with a high dosage of EB than did controls. On the basis of these observations, we conclude that receptivity in female pigs is not affected greatly by testosterone treatment at the stages of development that were investigated. Males castrated at birth and treated with a single injection of EB after 9.5 mo showed the immobilization response. In contrast, few males castrated at 8 mo or castrated at birth and treated with TP from 3 to 6 mo showed the immobilization response after EB treatment. These observations provide direct evidence for a postnatal component of testosterone-dependent defeminization of receptivity in male pigs. 相似文献
16.
Information about reproductive physiology in the Eurasian lynx (Lynx lynx) would generate knowledge that could be useful in the management of the Swedish lynx population based on the knowledge about their reproductive potential and population development. Age-related differences in ovulation and implantation rates would affect the reproductive output and the development of the population. The aims of this study were to evaluate a protocol for collection of reproductive data from carcasses by comparisons with published field data and to generate data about reproduction in the Swedish lynx. Reproductive organs from 120 females that were harvested between March 1 and April 9 from 2009 to 2011 were collected and evaluated macroscopically for placental scars. Females had their first estrus as yearlings but did not have their first litter until the next season. Pregnancy rates were lower in 2-year-old females than in females aged 3 to 7 years but did not differ significantly from females aged 8 to 13 years (54.5%, 95.6%, and 75.0%, respectively). CL from the present season were morphologically distinctly different from luteal bodies from previous cycles (LBPC). All females ≥3 years had macroscopically visible LBPC, whereas only 67% of 22 to 23 months old females had one to three LBPC and no females <1 year of age had LBPC. Females aged 34 to 35 months had up to eight LPBC, whereas the highest number of LBPC counted in females ≥3 years of age was 11. These data would be in agreement with only one estrus per season and LBPC from at least three previous reproductive seasons in older females. The number of LBPC was significantly correlated with the weight of the ovaries rs = 0.648, P < 0.001) and the age of the animals (rs = 0.572, P < 0.001). Uterine weight differed significantly with the stage of the reproductive cycle and was highest for mature females in the luteal phase of the cycle. The estrous period, defined as occurrence of ovarian follicles lasted from March 5 to April 1 in this material. In conclusion, this study confirms that useful information about lynx reproduction can be collected from reproductive organs retrieved after the death of the animals. Continuous monitoring of lynx reproductive organs would therefore make a valuable contribution to collection of field data, gathering information that can be useful for the management of lynx populations and potentially for the lynx as an indicator of environmental disturbances. 相似文献
17.
Astasheva NP Annenko v BN Khramtsova LK Finov VP 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2004,44(1):43-46
In experiments with broiler chicken the influence of gamma-irradiation (137Cs) to survive and productivity of meat poultry was studied. LD50/30 increased from 10.0 to 18.7 Gy with increasing of the age of the irradiated chicken from 3 to 40 days and reduced from 18.3 to 11.9 Gy with increasing of a dose rate from 1.0 to 40.0 Gy/h. As a rule, death of chicken was observed between 4th and 15th days after the exposure; the most early dates of poultry death were found at irradiation dose rate of 40.0 Gy/h. The exposure to doses of 8-20 Gy resulted in stunted growth; in comparison with control group the mass reduced by 22-32 g per each 1 Gy, lowering of meat productivity by 36%. 相似文献
18.
T A Rathbun 《American journal of physical anthropology》1987,74(2):239-253
The analysis of 36 human skeletons (eight subadults, 13 males, 15 females) recovered during a cemetery relocation near Charleston, SC, provides data on health and disease for a 19th-century sample of Afro-Americans. The majority of the burials date from 1840-1870. Skeletal analysis verified some historical interpretations. Gender differential in mortality is evident with average age at death for males 35 and females 40 years. Females, besides living longer, had more missing and carious teeth but fewer abscesses. Both genders expressed childhood metabolic stress as indicated by linear enamel hypoplasias. Males, however, had a higher incidence (92%) than did females (70%). Age at occurrence was more widely distributed for females, but ages 2-4 were most critical for both genders. Postcranial indications of recovery from acute stress, Harris lines, occurred more frequently for males (45%) than for females (18%). Anemia, probably both genetic and acquired, was a significant health problem for both genders. Cribra orbitalia appeared in 35% of the adult crania, and 80% of the subadults had orbital lesions. Diplotic expansion of the cranial vault and infection were relatively common in the sample. Skeletal reaction to infections appeared in 69% of the males, 60% of the females, and 80% of the subadults. Skeletal changes associated with demanding physical labor were ubiquitous. The shoulder and hip were especially affected by degenerative changes, the cervical vertebrae frequently expressed osteophytosis, and males show a preponderance of Schmorl herniations and hypertrophy of the ulnar supinator crest. Skeletal trace elements indicate a relatively high exposure to lead, strontium concentrations indicative of a diet high in plant foods, and relatively low zinc and copper concentrations. 相似文献
19.
In the female rat, the incidence of regular estrous cyclicity and fertility decreases progressively during aging, and the causes for these are unknown. To reveal the biology of pregnancy in aging rats, we performed a longitudinal study in a colony of multiparous rats bred every 2 mo. Beginning at 4 mo and continuing to 12 mo of age in these same individual females, we determined the chronological changes in estrous cyclicity, examined the relationship between the estrous cycle pattern and fertility, and recorded the numbers of live and dead pups delivered at term. In separate groups of 4- to 12-mo-old multiparous rats, we counted the number of ova present in the oviducts (ovulation rate) one day after mating and the number of grossly normal blastocysts found in the uteri on Day 5 of pregnancy. Similar studies were also performed in primiparous rats of 8, 10, and 12 mo of age. The cessation of regular cyclicity during aging occurred significantly (p less than 0.01) earlier in virgin than multiparous rats. Fertility followed a similar but more dramatic pattern of decline than did the incidence of regular cyclicity in both the multiparous and virgin females. Few irregularly cyclic and persistent-estrous females had fertile gestations after mating, and increasing proportions of regularly cyclic females also failed to reproduce successfully at middle age (8-12 mo). Thus, regular ovulatory cycles were essential but not sufficient for fertile gestations in aging rats. Beginning at 6 mo of age, the litter sizes of multiparous rats decreased progressively, and these decreases were associated with a similar decline in the number of live but not dead pups delivered. Also, the percentage of dead pups/total number of pups delivered increased steadily during aging in multiparous (from 14% to 69%) but not primiparous females. The litter sizes of 8- to 10-mo-old primiparous females were not different from those of multiparous rats. However, the litter sizes of irregularly cyclic rats were consistently smaller than those of regularly cyclic females. Thus, parity had little effect on fecundity in aging females, whereas the cessation of regular ovulatory cycles during aging greatly decreased both the incidence of fertility and the litter size.(ABSTRACT TRUNCATED AT 400 WORDS) 相似文献
20.
Cerroni AM Tomlinson GA Turnquist JE Grynpas MD 《American journal of physical anthropology》2003,121(3):252-269
This cross-sectional study investigates the relationship between parity, bone mineral density, and spontaneous osteopenia/osteoporosis in a large skeletal population of female rhesus macaques (Macaca mulatta) from the free-ranging colony of Cayo Santiago, Puerto Rico. The sample consists of 119 mature female monkeys aged 4.0-22.2 years at time of death. The data consist of measurements of bone mineral content (BMC) and bone mineral density (BMD), obtained from dual-energy X-ray absorptiometry (DEXA) of the last lumbar vertebra. After controlling for age, there is a significant increase in BMD of the spine with increasing parity (P = 0.0006), up to a parity of 7 offspring. Thus, high parity initially has a positive effect on BMD in female rhesus monkeys, but this positive effect disappears with parities that are greater than 7 offspring. After controlling for parity, however, age has a negative (P = 0.015) effect on BMD, beginning several years after the attainment of peak BMD (age 9.5 years). Thus, it appears that parity initially mitigates the effects of aging, but the positive effect of parity on BMD is eventually overwhelmed by the aging process. Mean BMC and BMD values are higher in parous females compared to nulliparous females in the same age range. Similarly, females with low parity have significantly lower mean BMD values than do age-matched high-parity controls, and the frequency of osteopenia and osteoporosis is greater in low-parity females. Forty-three percent (43%) of the osteopenic/osteoporotic females in the sample are members of the low-parity group, even though it composes only 13% (16/119) of the entire sample. This study demonstrates that the free-ranging female rhesus monkeys from Cayo Santiago are a good nonhuman primate model for the study of bone mineral density, parity, osteopenia, and osteoporosis. 相似文献