共查询到20条相似文献,搜索用时 15 毫秒
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V. M. Studitsky 《Molecular Biology》2005,39(4):549-563
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当RNA聚合酶Ⅱ(RNAPⅡ)离开启动子开始转录延伸时,会遇到包括紧密包装形成染色质的核小体在内的多种障碍,细胞内存在多种因子可协助RNAPⅡ克服这些障碍,保证转录的顺利进行。遗传和生化研究已经分离和鉴定了一些在此过程中起作用的延伸因子(elongation factor),现依据作用方式和效果对目前发现的主要延伸因子的研究进展进行了分类综述。 相似文献
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Joël Acker Marie-Genevive Mattei Marguerite Wintzerith Nathalie Roeckel Danile Depetris Marc Vigneron Claude Kedinger 《Genomics》1994,20(3)
The eukaryotic DNA-dependent RNA polymerase II (or B) is composed of 10 to 14 polypeptides ranging from 220 to 10 kDa. To gain further insight into the molecular structure and function of these subunits, we have undertaken the molecular cloning of nucleotide sequences corresponding to the human enzyme. The cDNAs of five subunits (hRPB220, hRPB140, hRPB33, hRPB25, and hRPB14.5) have been isolated. Using in situ hybridization, we show that the genes of these subunits have distinct chromosomal locations (17p13, 4q12, 16q13-q21, 19p13.3, and 19q12, respectively). Thus, if assembly of active polymerase molecules requires coordinated expression from these independent genes, mechanisms that ensure tight coregulation of the corresponding promoters must exist. 相似文献
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Diane C. Munday Weining Wu Nikki Smith Jenna Fix Sarah Louise Noton Marie Galloux Olivier Touzelet Stuart D. Armstrong Jenna M. Dawson Waleed Aljabr Andrew J. Easton Marie-Anne Rameix-Welti Andressa Peres de Oliveira Fernando M. Simabuco Armando M. Ventura David J. Hughes John N. Barr Rachel Fearns Paul Digard Jean-Fran?ois Eléou?t Julian A. Hiscox 《Journal of virology》2015,89(2):917-930
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Studitskiĭ VM 《Molekuliarnaia biologiia》2005,39(4):639-654
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Takayuki Nojima Martin Dienstbier Shona Murphy Nicholas J. Proudfoot Michael J. Dye 《Cell reports》2013,3(4):1080-1092
Highlights? Strategy for mapping mammalian Pol II terminator elements ? CoTC terminator elements mapped to endogenous gene loci ? Two modes of Pol II termination visualized at endogenous gene loci 相似文献
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