共查询到20条相似文献,搜索用时 15 毫秒
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The transforming growth factor (TGF)-beta signal-transduction cascade from the cell membrane to the nuclear target is poorly characterised. Here we report that treatment with TGF-beta1 induces the levels of endogenous c-fos mRNA in Rat-2 fibroblast cells. In addition, by transient transfection analysis, TGF-beta1 was shown to stimulate c-fos serum response element (SRE)-driven reporter gene activity in a dose- and time-dependent manner, suggesting that SRE is one of the nuclear targets of TGF-beta1. To understand the signalling cascade by which TGF-beta1 mediates the transactivation of c-fos SRE, cells were either pre-treated with various inhibitors or co-transfected with expression plasmids encoding inhibitory proteins for Rho GTPase together with the SRE-luciferase reporter gene. Our results showed that an inhibition of protein kinase C (PKC) or RhoA selectively repressed the stimulation of c-fos SRE by TGF-beta1, implying the possible roles of PKC and RhoA GTPase in TGF-beta1-induced signalling to c-fos SRE. 相似文献
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Functional dissection in vitro of the human c-fos promoter. 总被引:7,自引:0,他引:7
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A Gualberto D LePage G Pons S L Mader K Park M L Atchison K Walsh 《Molecular and cellular biology》1992,12(9):4209-4214
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v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements 总被引:13,自引:0,他引:13
S A Qureshi X M Cao V P Sukhatme D A Foster 《The Journal of biological chemistry》1991,266(17):10802-10806
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T G Parker K L Chow R J Schwartz M D Schneider 《The Journal of biological chemistry》1992,267(5):3343-3350