The biotech equipment and supplies sector in Europe-is it European?

Socio-economic research on biotechnology is dealing mainly with the sectors of biopharmaceuticals, agro-food or environmental technologies. In contrast, the equipment and supplies sector seems to be largely ignored. This is surprising because this sector provides important input in terms of technology and material for the development of biotechnology in general. Our comparative analysis of the sector in eight countries indicates that there exists no specific science base for the sector and that it is largely neglected by public research funding. Commercial activities are concentrated in countries with a large general science base in biotechnology and strong multinational pharmaceutical or chemical companies. There is a rather broad diversity in the way the sector has developed in the eight countries. Our data support the notion that national peculiarities seem dominant for explaining this picture. We anticipate growing business opportunities for European firms to step into large markets of equipment and supplies for functional genomics and protein analyses where Europe maintains a strong science base.     

Development of health biotechnology in developing countries: Can private-sector players be the prime movers?

Health biotechnology has rapidly become vital in helping healthcare systems meet the needs of the poor in developing countries. This key industry also generates revenue and creates employment opportunities in these countries. To successfully develop biotechnology industries in developing nations, it is critical to understand and improve the system of health innovation, as well as the role of each innovative sector and the linkages between the sectors. Countries' science and technology capacities can be strengthened only if there are non-linear linkages and strong interrelations among players throughout the innovation process; these relationships generate and transfer knowledge related to commercialization of the innovative health products. The private sector is one of the main actors in healthcare innovation, contributing significantly to the development of health biotechnology via knowledge, expertise, resources and relationships to translate basic research and development into new commercial products and innovative processes. The role of the private sector has been increasingly recognized and emphasized by governments, agencies and international organizations. Many partnerships between the public and private sector have been established to leverage the potential of the private sector to produce more affordable healthcare products. Several developing countries that have been actively involved in health biotechnology are becoming the main players in this industry. The aim of this paper is to discuss the role of the private sector in health biotechnology development and to study its impact on health and economic growth through case studies in South Korea, India and Brazil. The paper also discussed the approaches by which the private sector can improve the health and economic status of the poor.     

Globalization of biotechnology: The agglomeration of dispersed knowledge and information and its implications for the political economy of technology in developing countries

This study examines a contradictory development in the era of globalization wherein country-specific economic and socio-political institutional environment limits the global flow of technological knowledge and information, particularly in the biotechnology sector. International collaborations for developing new biotechnologies has increased significantly in recent years, but these have virtually bypassed firms in developing countries. The international flow of technologies tends to agglomerate in developed economies particularly in the US, where an appropriate mix of economic choices, social regulation and state action fostered institutional environments that facilitated the development and commercialization of biotechnologies. Moreover, with the heightening competition in the global economy, state and firms of developed economies have evolved into a relationship of close partnership. This shows that, far from being irrelevant, the state remains a political entity that structures the innovation system in order to promote the well-being of its firms. This calls for a re-thinking of the role of the state in technological and economic development, particularly among the developing economies.     

Economic issues for the UK biotechnology sector

This paper examines the economic prospects for the biotechnology industry, focusing on the UK position. I discuss some economic issues relating to the structure of the biotechnology industry and examine whether these factors can account for the relative success of the biotechnology sector in the UK compared to other European countries. I emphasize the importance of the science base, pharmaceutical companies and capital markets in giving the UK an advantage. Looking ahead I argue that prospects are good for the global growth of the industry due to supply and demand side factors. The UK is in a leading position in Europe but faces significant dangers, especially from the public towards biotechnology.     

Analysing biotechnology's traumas

Some of the most important factors that played a role in provoking the upheavals which overwhelmed the agri-foods biotechnology industry in Europe at the end of the 20th century are described and analysed, focusing especially on the impact of the introduction of a statutory labelling scheme that could be enforced. The implications of those upheavals for the development of biotechnology, for consumers and public policy makers, and corporate strategists, nationally and globally are outlined. The contention is that the trauma which overwhelmed the agri-food biotechnology sector in Europe had profound roots and rich implications which extend to the whole biotechnology sector and beyond.     

Three cases of imported dermatomycosis by Scytalidium dimidiatum

Scytalidium dimidiatum dermatomycosis are usually reported in tropical and subtropical countries. Some cases in Spain have been diagnosed due to the increasing number of immigrants from these areas. We herein describe three new cases of S. dimidiatum infections detected in Madrid. Two patients were from Guinea Ecuatorial and the third from Angola. We also report the first case of S. dimidiatum infection in a HIV patient in Spain. Clinical and epidemiological characteristics of S. dimidiatum infections reported in Spain are discussed.     

Integration of Lightning- and Human-Caused Wildfire Occurrence Models

Fire risk indices are useful tools for fire prevention actions by fire managers. A fire ignition is either the result of lightning or human activities. In European Mediterranean countries most forest fires are due to human activities. However, lightning is still an important fire ignition source in some regions. Integration of lightning and human fire occurrence probability into fire risk indices would be necessary to have a complete picture of the causal agents and their relative importance in fire occurrence. We present two methods for the integration of lightning and human fire occurrence probability models at 1 × 1 km grid cell resolution in two regions of Spain: Madrid, which presents a high fire incidence due to human activities; and Aragón, one of the most affected regions in Spain by lightning-fires. For validation, independent fire ignition points were used to compute the Receiver Operating Characteristic (ROC)-Area Under de Curve (AUC) and the Mahalanobis Distance. Results in Madrid are satisfactory for the human fire occurrence probability model (AUC～0.7) but less suitable for the lightning and the integrated models. In Aragón the fit for the human model is reasonable (AUC～0.7) whereas for the integration methods is practically useless (AUC～0.58).     

Variation in the life cycle and morphology of the tobacco host-race of Myzus persicae (Hemiptera: Aphididae) in relation to its geographical distribution

Morphological variation and life cycle category were examined in 121 clones of Myzus persicae (Sulzer). The clones were collected from tobacco from three localities in Greece (Xanthi, Nea Efessos and Naphplion), one in Germany (Rheinstetten), one in France (Bergerac) and one in Spain (Madrid). Before morphometrics, all aphids were laboratory-reared on potato. The morphological variation was investigated using both canonical variates analysis and a novel non-parametric classification tree method. The life cycle category was examined by rearing the clones for three generations under short day conditions. In Nea Efessos a relative high proportion of clones was found to overwinter as eggs on the primary host. In the other regions all collected clones were non-holocyclic. Intermediate genotypes were found in all regions at percentages ranging from 4.0 to 24.0%. Androcyclic clones were found only in Xanthi, Greece (4.0%) and Rheinstetten, Germany (16.7%). The canonical variates analysis and the tree classification method revealed important intrapopulation polymorphisms in clones from Bergerac, Nea Efessos and Madrid. Both methods separated the populations originating from Greece from those collected elsewhere in western Europe. The observed morphological variation was probably due to genetic differences, since all clones were reared in a common environment. The results are discussed in relation to factors responsible for genetic divergence in M. persicae populations.     

Biotechnology,people and markets

In assessing the likely demand for biotechnology products it is not sufficient just to look at what is happening in firms and their immediate market environment. There is no one 'market' for biotechnology products: there are differences between sectors and between countries. You have instead to look at the institutional contexts of the biotechnology product's development. This paper reviews work which has been carried out by social scientists, especially those using 'social shaping' approaches, on the development of new products based on advances in biotechnology and on the creation of markets to go with these products. It examines work on public attitudes to the exploitation of the technology, focusing especially on the issue of social inclusion and exclusion and how biotechnology might make exclusion more likely. It concludes by considering what current differences in public attitudes to the development of some biotechnology-based products might mean for the development of markets for those products in the UK.     

特殊酵母工业应用专利发展态势分析

特殊酵母作为区别于传统酵母之外的一类生物资源,具有广泛的工业应用前景.基于incoPat数据库收录的专利数据,以特殊酵母工业应用领域的专利为研究对象,从专利分析的角度,揭示了全球特殊酵母工业应用领域技术创新的发展态势、技术分布、主要申请机构、研究热点以及各类特殊酵母的应用优势等.结果表明:全球特殊酵母工业应用领域的专利...     

国外生物经济规模测算方法分析及对我国的启示

生物经济的概念自提出以来,美国、欧盟、英国、日本等都积极开展路线图规划和实施相关项目部署,以培育国内新的经济增长点,掌握未来国际竞争的主动权。近年来,生物科技领域创新与产业飞速发展,生物经济有望在国民经济中发挥更加凸显的作用和贡献,主导引领经济形态的新一次轮换。为了更好的掌握全球生物经济的发展现状和规模,对美国、欧盟和日本等几个具有代表性的国家/地区的生物经济测算方式开展了比较分析。在此基础上结合生物经济的定义,提出我国生物经济测算框架并得到初步测算结果,为我国生物经济发展决策提供科学的数据支撑。最后,对我国生物经济未来发展规模做出展望,同时也对我国生物经济测算框架的下一步改进进行了讨论。     

“一带一路”沿线国家生物技术发展趋势研究

“一带一路”贯穿亚欧非大陆,联结活跃的东亚经济圈和发达的欧洲经济圈,以及中间经济发展潜力巨大的广大腹地国家与地区,“一带一路”战略将对中国未来国内外的政治、经济、文化、科技发展产生重大深远影响。本报告分析了“一带一路”沿线国家的科技发展基础条件,研究了“一带一路”沿线国家在生物技术领域取得的基础研究进展和专利技术研发进展的总体情况,综述了“一带一路”沿线国家生物技术产业发展现状和国际专利布局情况,并针对中国与“一带一路”沿线国家在生物技术领域进一步深化合作互利共赢提出了发展建议。     

Economic Development Matters: A Meta‐Regression Analysis on the Relation between Environmental Management and Financial Performance

Although the existing body of empirical literature on the relation between corporate environmental performance (CEP) and corporate financial performance (CFP) is continuously growing, results are still inconclusive about this fundamental question in industrial ecology. Comparisons are difficult because of various estimation methods as well as the overall heterogeneous and complex interaction between the two constructs, but especially because of country‐specific data sets. Consequently, we raise the question of whether regional differences are the driving force buried underneath the inconclusiveness. Therefore, the aim of this article is to explore this heterogeneity by aggregating 893 existing results from 142 empirical primary studies that are based on more than 750,000 firm‐year observations. Our findings suggest a convex impact of a country's economic development on the magnitude of the CEP‐CFP effect (i.e., the effect is positive in developing countries, disappears in emerging countries, and is again positive in highly developed countries). We also find that the overall positive relation strengthens for market‐based CFP measures and diminishes for countries with civil law systems, firms from the service sector, reactive environmental activities, and process‐based CEP measures. Further, several aspects of the examined data sample and the inclusion of relevant control variables explain heterogeneity in previous research results.     

Challenges facing European agriculture and possible biotechnological solutions

Agriculture faces many challenges to maximize yields while it is required to operate in an environmentally sustainable manner. In the present study, we analyze the major agricultural challenges identified by European farmers (primarily related to biotic stresses) in 13 countries, namely Belgium, Bulgaria, the Czech Republic, France, Germany, Hungary, Italy, Portugal, Romania, Spain, Sweden, UK and Turkey, for nine major crops (barley, beet, grapevine, maize, oilseed rape, olive, potato, sunflower and wheat). Most biotic stresses (BSs) are related to fungi or insects, but viral diseases, bacterial diseases and even parasitic plants have an important impact on yield and harvest quality. We examine how these challenges have been addressed by public and private research sectors, using either conventional breeding, marker-assisted selection, transgenesis, cisgenesis, RNAi technology or mutagenesis. Both national surveys and scientific literature analysis followed by text mining were employed to evaluate genetic engineering (GE) and non-GE approaches. This is the first report of text mining of the scientific literature on plant breeding and agricultural biotechnology research. For the nine major crops in Europe, 128 BS challenges were identified with 40% of these addressed neither in the scientific literature nor in recent European public research programs. We found evidence that the private sector was addressing only a few of these “neglected” challenges. Consequently, there are considerable gaps between farmer’s needs and current breeding and biotechnology research. We also provide evidence that the current political situation in certain European countries is an impediment to GE research in order to address these agricultural challenges in the future. This study should also contribute to the decision-making process on future pertinent international consortia to fill the identified research gaps.     

Green biotechnology and European competitiveness

Europe has led many aspects of gene research and yet it has been unable to translate these discoveries into a globally dominant industrial sector. There are valid societal, political and financial reasons for its reluctance to deploy agricultural biotechnology but this reluctance might have unintended consequences. It will be hard to de-commoditize agriculture and improve farmer's lives. Research in medical biotechnology and the global environment might suffer. Europe could damage its overall economy and its global competitive standing.     

The role of language and the presence of previous immigration cohorts in immigrant political engagement: Ecuadorian collective action in New York City and Madrid

Scholarship on immigration has recently begun to examine the social process by which immigrants make collective demands. By focussing on the case of Ecuadorian immigrants in New York City and Madrid, this comparative analysis shows that in addition to differences in the political opportunity structures in these cities, there are at least two additional contextual differences shaping the ways in which participants in this study mobilize. Mobilization is shaped by the presence or absence of previous immigration cohorts and by linguistic differences. The findings reveal the value of undertaking comparative case analysis to shed light on immigrant collective political engagement.     

Molecular surveillance of HIV-1 in Madrid, Spain: a phylogeographic analysis

The molecular epidemiology of HIV-1 is constantly changing, mainly as a result of human migratory flows and the high adaptive ability of the virus. In recent years, Spain has become one of Europe''s main destinations for immigrants and one of the western European countries with the highest rates of HIV-positive patients. Using a phylogeographic approach, we have analyzed the relationship between HIV-1 variants detected in immigrant and native populations of the urban area of Madrid. Our project was based on two coincidental facts. First, resistance tests were extended to naïve and newly diagnosed patients, and second, the Spanish government legislated the provision of legal status to many immigrants. This allowed us to obtain a large data set (n = 2,792) from 11 Madrid hospitals of viral pol sequences from the two populations, and with this unique material, we explored the impact of immigration in the epidemiological trends of HIV-1 variants circulating in the largest Spanish city. The prevalence of infections by non-B HIV-1 variants in the studied cohort was 9%, rising to 25% among native Spanish patients. Multiple transmission events involving different lineages and subsubtypes were observed in all the subtypes and recombinant forms studied. Our results also revealed strong social clustering among the most recent immigrant groups, such as Russians and Romanians, but not in those groups who have lived in Madrid for many years. Additionally, we document for the first time the presence of CRF47_BF and CRF38_BF in Europe, and a new BG recombinant form found in Spaniards and Africans is tentatively proposed. These results suggest that the HIV-1 epidemic will evolve toward a more complex epidemiological landscape.     

Forest and the city: A multivariate analysis of peri-urban forest land cover patterns in 283 European metropolitan areas

Heterogeneous definitions of urban areas and poorly homogenized forest data at the country scale have hampered the comparative assessment of peri-urban forest structure in developed countries. The present study investigates selected landscape characteristics of peri-urban forests in 283 metropolitan areas in Europe controlling for the role of the local context and regional suburbanization trends. Using landscape metrics derived from Urban Atlas maps (a Copernicus/GMES initiative providing a comprehensive land-use assessment of European cities >100,000 inhabitants), significant differences in peri-urban forest structure were detected under five European regions. Specific class metrics (percent forest area, mean patch size, perimeter-to-area ratio) were correlated with urban morphology, landscape and territorial indicators. On average, forest cover is larger in northern and southern European metropolitan areas. Forest patch size increases from western to eastern Europe, with more regular patch shapes in central and eastern regions and less regular shapes in the rest of Europe. Forest class area increases with the area of discontinuous, medium-density settlements. Forest patch size increases with the average patch size of discontinuous dense urban fabric. Our evidence outlines a ‘sprawl model' shaping fringe landscapes characterized by discontinuous urban settlements mixed with fragmented – but possibly well protected – forest patches.     

Biotechnology and the Third World: the missing link between research and applications

A United Nations University study investigated the activities of four major United Nations agencies that focussed on helping developing countries gain advanced capabilities in biotechnology. Relevant program and project documents were scrutinized at agency headquarters and managers were interviewed. Then, projects underway in three case countries (Egypt, Thailand, and Venezuela) were examined. The resulting information was used to assess whether United Nations projects were fulfilling these countries' needs and (or) advancing their capabilities in biotechnology. The minute, United Nations originated assistance available was directed solely at increasing capabilities in research and thus benefited bioscientists and their institutes. However, as virtually no linkage exists between the research establishment and the industrial--marketing sector, results from indigenous research does not reach industrialists or health workers. Consequently, biotechnology is neither advancing economic development in the case countries nor helping solve national problems. This situation is likely to persist because corrective systemic changes will be difficult to implement. Major implications of these findings are discussed, particularly as they bear on the United Nations system.